DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7800 and CG4950

DIOPT Version :9

Sequence 1:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	133/589 - (22%)
Similarity:	228/589 - (38%)	Gaps:	118/589 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIIIALLASVSALGR-PDLEDYC-----------NDSYCHLLGRSRTFSDK---------KATKL 46
            :|:|.:||..|..|. .|:...|           |:::|.:.|.:.|.|..         ...|.
  Fly    10 VIVILILAISSCDGSGGDIPLRCDEYDSMGYMDVNEAFCTVTGFTVTHSQNVVIKNIPPGNMVKF 74

  Fly    47 TEFHMDSCEKKVLKLMPNLRTLELENCDSPDFTMNDLNQLPYLTSLQLRRGNLLGLHDEHFSKWP 111
            .:|:     :..|..||                .:.....|||.:|.:...|:|.|....||...
  Fly    75 MKFY-----ESTLLYMP----------------FHLFETFPYLKTLDVSNTNILELTRNAFSAAS 118

  Fly   112 NMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIETLHE 176
            |:..|.|..||:|.:....|.|...|..|.|..|.|..|..:.|..|..:..:.|:||.::.||.
  Fly   119 NLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHN 183

  Fly   177 NIFTGVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSNCGPL---PDLSLPGA---------- 228
            :||.....||.:...||.||.|.|...:::..::.:::||...:   ||.....|
  Fly   184 DIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYN 248

  Fly   229 -------------HTLILDNSGVQRLDILGSVHKLQARKNHITEIKLPDKSSVIELDLHSNLLTA 280
                         |.|.|||:.:..|.| .:...::|..|.|:|:.|.....:..|||.:|.|::
  Fly   249 ELKNFQLTEKNIVHQLHLDNNYLTNLTI-NATRFVRASHNQISELFLHQSLHIETLDLSANKLSS 312

  Fly   281 TDIPKLLTGMWRLQRLDLSENIIGIYAAAGSDNTSELFILPNLMYMNLSANRLTRLHFDSPIPWE 345
            .   ..:|.:..:..||:|:|.||..      |.|....|..|..:||....:..|.|......:
  Fly   313 I---SNITNITHMLYLDVSDNPIGPL------NISTFSQLKRLRGLNLRGTGIRELKFGMFSKQK 368

  Fly   346 RLTHLDASYNRI-------YAPAKVGIDEAFNLQSLHLEGNYINNFE--LTPWKPHPSLKEVALY 401
            .|..||.|:|.:       :.|...      ||:...::||.:...:  .|..:..|.|:::.:.
  Fly   369 YLEELDLSFNNLTILNLDMFVPYLT------NLKKFLIDGNGLTELQGNRTFSEAFPQLQKLGVS 427

  Fly   402 DNKFQPKGYKNI---TKFFNEIGVNVLEKTQYSQSNNTTPTCK--PCIPDARDFPTSISADTNQT 461
            .|:|......::   ......:.:|:...|...:    ||..:  .||..:::...:........
  Fly   428 RNRFNCSYLHHLLIPPSLPESVVLNIEPDTNLDE----TPHIRDVSCISQSQEVVNASFTAEESK 488

  Fly   462 IDTKVNPLSND-----TYQWNVWNVLMLVSLIVSLFVNSFL----IVKLIRLRG-RNQ----FTQ 512
            :::::..||..     ::..|:  .|.|..:.:..:|...|    :|.||.||. :||    :.:
  Fly   489 LESQIQMLSKQLDIVGSHSKNL--ELHLAFMQIFAYVMGGLVLVGVVSLITLRYLKNQRSGRYDR 551

  Fly   513 SSSV 516
            ||.|
  Fly   552 SSIV 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	3/17 (18%)
		leucine-rich repeat	65..85	CDD:275380	0/19 (0%)
		LRR_8	87..147	CDD:290566	21/59 (36%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	<131..334	CDD:238064	60/228 (26%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		LRR_8	140..195	CDD:290566	18/54 (33%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..246	CDD:275380	12/62 (19%)
		leucine-rich repeat	247..267	CDD:275380	5/19 (26%)
		leucine-rich repeat	268..292	CDD:275380	6/23 (26%)
		leucine-rich repeat	293..322	CDD:275380	9/28 (32%)
		leucine-rich repeat	395..406	CDD:275378	2/10 (20%)
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	7/22 (32%)
		LRR_8	118..178	CDD:290566	19/59 (32%)
		leucine-rich repeat	120..143	CDD:275380	7/22 (32%)
		leucine-rich repeat	144..167	CDD:275380	8/22 (36%)
		leucine-rich repeat	168..191	CDD:275380	7/22 (32%)
		LRR_8	192..250	CDD:290566	13/57 (23%)
		leucine-rich repeat	192..215	CDD:275380	8/22 (36%)
		LRR_RI	<207..432	CDD:238064	52/240 (22%)
		leucine-rich repeat	216..239	CDD:275380	4/22 (18%)
		leucine-rich repeat	240..299	CDD:275380	12/59 (20%)
		LRR_8	299..356	CDD:290566	18/65 (28%)
		leucine-rich repeat	300..321	CDD:275380	6/23 (26%)
		leucine-rich repeat	322..345	CDD:275380	9/28 (32%)
		LRR_8	344..405	CDD:290566	15/66 (23%)
		leucine-rich repeat	346..365	CDD:275380	5/18 (28%)
		leucine-rich repeat	370..394	CDD:275380	6/29 (21%)
		leucine-rich repeat	395..420	CDD:275380	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453830
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940