Protein Alignment CG7800 and NRROS

DIOPT Version :10

• Sequence 1: NP_649770.1
• Gene: CG7800 / 40963
• FlyBaseID: FBgn0037552
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_940967.1
• Gene: NRROS / 375387
• HGNCID: 24613
• Length: 692
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 100/370 - (27%)
• Similarity: 160/370 - (43%)
• Gaps: 70/370 - (18%)

  Fly    42 KATKLTEFHMDSCEKKVLKLMPNLRTLEL-ENCDSPDF--TMNDLNQLPYLTSLQLRRGNLL--- 100
            ::..|...|::...:...:...:||:|.| :||.|.::  |...|:.||.|..|.| .||.|
Human    84 ESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDL-SGNALTED 147

  Fly   101 --GLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLH 163
              .|..::.|   :::.:.|.||.|.||.:..|:||.:|..|.|..|.|..:....|..|.||.|
Human   148 MAALMLQNLS---SLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRH 209

  Fly   164 LDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSN-----CGPLPDL 223
            |:|:.|.:..:   :..|:.:|.:|.::.|.|.|...|..::...|..||:|:     ...||..
Human   210 LNLAFNNLPCI---VDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQY 271

  Fly   224 SLPGAHTLIL--DNSGVQRLDILGSVHKLQARKNHITEIKLPDKSSVIELDLHSNLLTATDIPKL 286
            |  ...||:|  :|.|..|     .::...:.:..:.:..|.|          .|:...|.:
Human   272 S--KLRTLLLRDNNMGFYR-----DLYNTSSPREMVAQFLLVD----------GNVTNITTV--- 316

  Fly   287 LTGMWR---------LQRLDLSENIIGIYAAAGSDNTSELFI--LPNLMYMNLSANRLTRLHFDS 340
              .:|.         |:.||:|:|... |...|       |:  :|:|.::||..|.|..||...
Human   317 --SLWEEFSSSDLADLRFLDMSQNQFQ-YLPDG-------FLRKMPSLSHLNLHQNCLMTLHIRE 371

  Fly   341 PIPWERLTHLDASYNRI----YAP---AKVGIDEAFNLQSLHLEG 378
            ..|...||.||.|:|::    .||   :.:|....|||.|..|.|
Human   372 HEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLG 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	2/17 (12%)
		leucine-rich repeat	65..85	CDD:275380	9/22 (41%)
		LRR	68..482	CDD:443914	96/344 (28%)
		leucine-rich repeat	89..112	CDD:275380	8/27 (30%)
		leucine-rich repeat	113..136	CDD:275380	9/22 (41%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..184	CDD:275380	6/22 (27%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..246	CDD:275380	13/43 (30%)
		leucine-rich repeat	247..267	CDD:275380	2/19 (11%)
		leucine-rich repeat	268..292	CDD:275380	2/23 (9%)
		leucine-rich repeat	293..322	CDD:275380	8/30 (27%)
		leucine-rich repeat	395..406	CDD:275378
NRROS	NP_940967.1	leucine-rich repeat	42..61	CDD:275380
		LRR 1. /evidence=ECO:0000255	58..79
		leucine-rich repeat	62..82	CDD:275380
		LRR 2. /evidence=ECO:0000255	82..103		2/18 (11%)
		leucine-rich repeat	83..106	CDD:275380	2/21 (10%)
		LRR	<106..414	CDD:443914	96/344 (28%)
		LRR 3. /evidence=ECO:0000255	106..127		8/20 (40%)
		leucine-rich repeat	107..133	CDD:275380	10/25 (40%)
		LRR 4. /evidence=ECO:0000255	133..155		7/22 (32%)
		leucine-rich repeat	134..158	CDD:275380	8/27 (30%)
		LRR 5. /evidence=ECO:0000255	158..179		7/20 (35%)
		leucine-rich repeat	159..182	CDD:275380	9/22 (41%)
		LRR 6. /evidence=ECO:0000255	182..203		6/20 (30%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		LRR 7. /evidence=ECO:0000255	206..227		7/23 (30%)
		leucine-rich repeat	207..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		LRR 8. /evidence=ECO:0000255	228..239		3/10 (30%)
		LRR 9. /evidence=ECO:0000255	251..272		6/20 (30%)
		leucine-rich repeat	252..273	CDD:275380	7/22 (32%)
		LRR 10. /evidence=ECO:0000255	273..294		6/25 (24%)
		LRR	293..>595	CDD:443914	37/147 (25%)
		LRR 11. /evidence=ECO:0000255	329..350		8/28 (29%)
		leucine-rich repeat	330..353	CDD:275380	8/30 (27%)
		LRR 12. /evidence=ECO:0000255	353..374		7/20 (35%)
		leucine-rich repeat	354..377	CDD:275380	8/22 (36%)
		LRR 13. /evidence=ECO:0000255	377..398		8/20 (40%)
		leucine-rich repeat	378..403	CDD:275380	8/24 (33%)
		LRR 14. /evidence=ECO:0000255	403..424		6/14 (43%)
		leucine-rich repeat	404..427	CDD:275380	6/13 (46%)
		LRR 15. /evidence=ECO:0000255	427..447
		leucine-rich repeat	428..463	CDD:275380
		LRR 16. /evidence=ECO:0000255	463..484
		leucine-rich repeat	464..486	CDD:275380
		LRR 17. /evidence=ECO:0000255	486..507
		leucine-rich repeat	487..512	CDD:275380
		LRR 18. /evidence=ECO:0000255	512..534
		leucine-rich repeat	513..537	CDD:275380
		LRR 19. /evidence=ECO:0000255	537..558
		leucine-rich repeat	538..559	CDD:275380
		LRR 20. /evidence=ECO:0000255	559..580
		LRR 21. /evidence=ECO:0000255	585..594