DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7800 and NRROS

DIOPT Version :9

Sequence 1:NP_649770.1 Gene:CG7800 / 40963 FlyBaseID:FBgn0037552 Length:533 Species:Drosophila melanogaster
Sequence 2:NP_940967.1 Gene:NRROS / 375387 HGNCID:24613 Length:692 Species:Homo sapiens


Alignment Length:370 Identity:100/370 - (27%)
Similarity:160/370 - (43%) Gaps:70/370 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 KATKLTEFHMDSCEKKVLKLMPNLRTLEL-ENCDSPDF--TMNDLNQLPYLTSLQLRRGNLL--- 100
            ::..|...|::...:...:...:||:|.| :||.|.::  |...|:.||.|..|.| .||.|   
Human    84 ESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDL-SGNALTED 147

  Fly   101 --GLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLH 163
              .|..::.|   :::.:.|.||.|.||.:..|:||.:|..|.|..|.|..:....|..|.||.|
Human   148 MAALMLQNLS---SLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRH 209

  Fly   164 LDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSN-----CGPLPDL 223
            |:|:.|.:..:   :..|:.:|.:|.::.|.|.|...|..::...|..||:|:     ...||..
Human   210 LNLAFNNLPCI---VDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQY 271

  Fly   224 SLPGAHTLIL--DNSGVQRLDILGSVHKLQARKNHITEIKLPDKSSVIELDLHSNLLTATDIPKL 286
            |  ...||:|  :|.|..|     .::...:.:..:.:..|.|          .|:...|.:   
Human   272 S--KLRTLLLRDNNMGFYR-----DLYNTSSPREMVAQFLLVD----------GNVTNITTV--- 316

  Fly   287 LTGMWR---------LQRLDLSENIIGIYAAAGSDNTSELFI--LPNLMYMNLSANRLTRLHFDS 340
              .:|.         |:.||:|:|... |...|       |:  :|:|.::||..|.|..||...
Human   317 --SLWEEFSSSDLADLRFLDMSQNQFQ-YLPDG-------FLRKMPSLSHLNLHQNCLMTLHIRE 371

  Fly   341 PIPWERLTHLDASYNRI----YAP---AKVGIDEAFNLQSLHLEG 378
            ..|...||.||.|:|::    .||   :.:|....|||.|..|.|
Human   372 HEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLG 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7800NP_649770.1 leucine-rich repeat 46..64 CDD:275380 2/17 (12%)
leucine-rich repeat 65..85 CDD:275380 9/22 (41%)
LRR_8 87..147 CDD:290566 22/64 (34%)
leucine-rich repeat 89..112 CDD:275380 8/27 (30%)
leucine-rich repeat 113..136 CDD:275380 9/22 (41%)
LRR_RI <131..334 CDD:238064 54/220 (25%)
leucine-rich repeat 137..160 CDD:275380 7/22 (32%)
LRR_8 140..195 CDD:290566 16/54 (30%)
leucine-rich repeat 161..184 CDD:275380 6/22 (27%)
leucine-rich repeat 185..208 CDD:275380 6/22 (27%)
leucine-rich repeat 209..246 CDD:275380 13/43 (30%)
leucine-rich repeat 247..267 CDD:275380 2/19 (11%)
leucine-rich repeat 268..292 CDD:275380 2/23 (9%)
leucine-rich repeat 293..322 CDD:275380 8/30 (27%)
leucine-rich repeat 395..406 CDD:275378
NRROSNP_940967.1 leucine-rich repeat 42..61 CDD:275380
LRR 1. /evidence=ECO:0000255 58..79
leucine-rich repeat 62..82 CDD:275380
LRR_RI 76..>285 CDD:238064 61/209 (29%)
LRR_8 81..144 CDD:290566 18/60 (30%)
LRR 2. /evidence=ECO:0000255 82..103 2/18 (11%)
leucine-rich repeat 83..106 CDD:275380 2/21 (10%)
LRR 3. /evidence=ECO:0000255 106..127 8/20 (40%)
leucine-rich repeat 107..133 CDD:275380 10/25 (40%)
LRR 4. /evidence=ECO:0000255 133..155 7/22 (32%)
leucine-rich repeat 134..158 CDD:275380 8/27 (30%)
LRR_8 157..217 CDD:290566 23/62 (37%)
LRR 5. /evidence=ECO:0000255 158..179 7/20 (35%)
leucine-rich repeat 159..182 CDD:275380 9/22 (41%)
LRR 6. /evidence=ECO:0000255 182..203 6/20 (30%)
leucine-rich repeat 183..206 CDD:275380 7/22 (32%)
LRR 7. /evidence=ECO:0000255 206..227 7/23 (30%)
leucine-rich repeat 207..227 CDD:275380 6/22 (27%)
leucine-rich repeat 228..251 CDD:275380 6/22 (27%)
LRR 8. /evidence=ECO:0000255 228..239 3/10 (30%)
LRR 9. /evidence=ECO:0000255 251..272 6/20 (30%)
leucine-rich repeat 252..273 CDD:275380 7/22 (32%)
LRR 10. /evidence=ECO:0000255 273..294 6/25 (24%)
LRR 11. /evidence=ECO:0000255 329..350 8/28 (29%)
LRR_8 330..388 CDD:290566 23/65 (35%)
leucine-rich repeat 330..353 CDD:275380 8/30 (27%)
LRR 12. /evidence=ECO:0000255 353..374 7/20 (35%)
leucine-rich repeat 354..377 CDD:275380 8/22 (36%)
LRR_RI 357..594 CDD:238064 22/60 (37%)
LRR 13. /evidence=ECO:0000255 377..398 8/20 (40%)
LRR_8 378..438 CDD:290566 15/39 (38%)
leucine-rich repeat 378..403 CDD:275380 8/24 (33%)
LRR 14. /evidence=ECO:0000255 403..424 6/14 (43%)
leucine-rich repeat 404..427 CDD:275380 6/13 (46%)
LRR 15. /evidence=ECO:0000255 427..447
leucine-rich repeat 428..463 CDD:275380
LRR 16. /evidence=ECO:0000255 463..484
leucine-rich repeat 464..486 CDD:275380
LRR 17. /evidence=ECO:0000255 486..507
leucine-rich repeat 487..512 CDD:275380
LRR 18. /evidence=ECO:0000255 512..534
LRR_8 513..570 CDD:290566
leucine-rich repeat 513..537 CDD:275380
LRR 19. /evidence=ECO:0000255 537..558
leucine-rich repeat 538..559 CDD:275380
LRR 20. /evidence=ECO:0000255 559..580
LRR 21. /evidence=ECO:0000255 585..594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45617
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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