Protein Alignment CG7800 and IGFALS

DIOPT Version :10

• Sequence 1: NP_649770.1
• Gene: CG7800 / 40963
• FlyBaseID: FBgn0037552
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001139478.1
• Gene: IGFALS / 3483
• HGNCID: 5468
• Length: 643
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 126/474 - (26%)
• Similarity: 186/474 - (39%)
• Gaps: 111/474 - (23%)

  Fly    51 MDSCEKKVLKLMPNLRTLELENCDSPDFTMNDLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKI 115
            :.|.|.:.|..:.||..|.||........:......|.|.||.|....|..|.|..|....::..
Human   148 LGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWD 212

  Fly   116 LMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIETLHENIFT 180
            |.||.|::..|.:..|:||..|..|.|.||.:..|...:|..|.||..||||.|.:..:..|:|.
Human   213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 277

  Fly   181 GVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSN---CGPLPDLSLPG---------AHTLI- 232
            .:|:|:.|.|:.|.:..:||.:...|..||.||:|:   .|.|.| :.||         :|..|
Human   278 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED-TFPGLLGLRVLRLSHNAIA 341

  Fly   233 -----------------LDNSGVQRL-----DILGSVHKLQARKNHITEIK-------------- 261
                             |.::.:::|     :.||.:..|....|.:.|:|
Human   342 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMN 406

  Fly   262 --------LPDKSSVIELDLHSNLLTATDI----PKLLTGMWRLQRLDLSEN-IIGIYAAA---- 309
                    ||::.......|||..|..:.:    |...||:..|:||.|.:| ::||...:
Human   407 LSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 471

  Fly   310 ----GSDNTS-ELFILPN--------LMYMNLSANRLTRLHFDSPIPWERLTHLDASYNRIYAPA 361
                ..|.|| :|..||:        |.|:.||.|||..|..|:..|.:|...||.|:||:.|..
Human   472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALP 536

  Fly   362 KVGIDEAFNLQSLHLEGNYINNF------------ELTPWK---PHPSLKEVALYDNKFQPK--- 408
            ...:.....|:.|.|..|.:..|            |..||.   |..:|::.||.:....|:
Human   537 NSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQ 601

  Fly   409 -------------GYKNIT 414
                         .|.|||
Human   602 AICEGDDCQPPAYTYNNIT 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	3/12 (25%)
		leucine-rich repeat	65..85	CDD:275380	4/19 (21%)
		LRR	68..482	CDD:443914	121/457 (26%)
		leucine-rich repeat	89..112	CDD:275380	8/22 (36%)
		leucine-rich repeat	113..136	CDD:275380	8/22 (36%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..246	CDD:275380	15/71 (21%)
		leucine-rich repeat	247..267	CDD:275380	6/41 (15%)
		leucine-rich repeat	268..292	CDD:275380	7/27 (26%)
		leucine-rich repeat	293..322	CDD:275380	12/38 (32%)
		leucine-rich repeat	395..406	CDD:275378	3/10 (30%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470
		leucine-rich repeat	95..113	CDD:275380
		leucine-rich repeat	114..137	CDD:275380
		LRR	132..574	CDD:443914	115/426 (27%)
		leucine-rich repeat	138..161	CDD:275380	3/12 (25%)
		leucine-rich repeat	162..185	CDD:275380	4/22 (18%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..233	CDD:275380	8/22 (36%)
		leucine-rich repeat	234..257	CDD:275380	8/22 (36%)
		leucine-rich repeat	258..281	CDD:275380	8/22 (36%)
		leucine-rich repeat	282..305	CDD:275380	7/22 (32%)
		leucine-rich repeat	306..324	CDD:275380	8/18 (44%)
		leucine-rich repeat	354..377	CDD:275380	3/22 (14%)
		leucine-rich repeat	378..401	CDD:275380	4/22 (18%)
		leucine-rich repeat	402..423	CDD:275380	2/20 (10%)
		leucine-rich repeat	426..447	CDD:275380	6/20 (30%)
		leucine-rich repeat	450..473	CDD:275380	7/22 (32%)
		leucine-rich repeat	474..497	CDD:275380	6/22 (27%)
		leucine-rich repeat	498..519	CDD:275380	9/20 (45%)
		leucine-rich repeat	522..543	CDD:275380	6/20 (30%)
		leucine-rich repeat	546..565	CDD:275380	5/18 (28%)
		LRRCT	574..618	CDD:214507	8/43 (19%)