DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7800 and Toll-4

DIOPT Version :9

Sequence 1:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	116/588 - (19%)
Similarity:	198/588 - (33%)	Gaps:	200/588 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EDYCNDSYCHLLGRSRTFSDKKATKLTEFHMDSCEKKV-LKLMPNLRTLELEN------CDSPDF 78
            |||| :.|...||.:.|.|.......||   |...|.| |||..|..:.....      |:..|:
  Fly    90 EDYC-EIYLDELGENGTCSIANNEVTTE---DYQMKLVFLKLEINWTSPVFHGWNIFKICNETDY 150

  Fly    79 TMNDLNQLPYLTSLQLRRG------NLLGLH-----------------DEHFSKWPNMKILMLGG 120
            .:..::.|...:.:.:|..      :|||:.                 |.|.:..|.|
  Fly   151 ELVIISVLGIRSEVDMRISPAVQYLSLLGIREISGYDIYLPSVLITEMDVHHANGPKM------- 208

  Fly   121 NNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIE----TLHENIFTG 181
              :|      ||.|....:.|:..|.......:..:.:....|     |..|    |:.:|||.|
  Fly   209 --VT------FKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYH-----NTFEKTTLTMEKNIFHG 260

  Fly   182 VPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSNCGPLPDLSLPGAHTL-------------IL 233
            ..|:..|:.||..:..:...:.::|::|..|...|.. |.|||...:.||             ::
  Fly   261 KNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVF-LKDLSFLRSSTLQSSLTYCIMKVDNMV 324

  Fly   234 DNSGVQRLDILGSVHKLQAR-------------KNH------ITEIKLP---------DKSSVIE 270
            |....::...|..:...|.:             |:|      |.|:..|         |||. :|
  Fly   325 DLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQ-LE 388

  Fly   271 LDL-HSNLLTATDIPKLLTGMWRLQRLDLSENIIGIYAAAGSDNTSELFILPNLMYMNLSANRLT 334
            :|. ..||.|...:|....|.   ..|....|::    |...||:.|.:  .||..:::|.|:||
  Fly   389 IDCWQKNLTTIPSLPVPKKGS---SALVFQSNLL----AELPDNSLEGY--HNLKSLDVSYNQLT 444

  Fly   335 RLHFDSPIPWERLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELTPWKPHPSLKEVA 399
            .|.. |.:| |.|.:||..:|:|...:...::..:::...:..||        .|         :
  Fly   445 SLSV-SQLP-ESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGN--------KW---------S 490

  Fly   400 LYDNKFQPKGYKNITKFFNEIGVNVLEKTQYSQSNNTTPTCKPCIPDARDFPTSISADTNQTIDT 464
            :|.:::      ::.:||
  Fly   491 IYCDEY------HLQEFF----------------------------------------------- 502

  Fly   465 KVNPLSNDTYQWNVWNVLMLVSLIVSLFVNSFLIVKLIRLRGRNQFTQSSSVPAIIEMFSNESDD 529
                          |....|:.:..|.|..   |::.|.|..:..|.::..|..|.:::...::|
  Fly   503 --------------WYKAKLLRIKTSKFQT---IMEYIELSSKGSFVENFFVQNIDQLYLEANED 550

  Fly   530 EII 532
            |||
  Fly   551 EII 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	8/18 (44%)
		leucine-rich repeat	65..85	CDD:275380	2/25 (8%)
		LRR_8	87..147	CDD:290566	14/82 (17%)
		leucine-rich repeat	89..112	CDD:275380	6/45 (13%)
		leucine-rich repeat	113..136	CDD:275380	5/22 (23%)
		LRR_RI	<131..334	CDD:238064	55/248 (22%)
		leucine-rich repeat	137..160	CDD:275380	2/22 (9%)
		LRR_8	140..195	CDD:290566	14/58 (24%)
		leucine-rich repeat	161..184	CDD:275380	8/26 (31%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..246	CDD:275380	11/49 (22%)
		leucine-rich repeat	247..267	CDD:275380	8/47 (17%)
		leucine-rich repeat	268..292	CDD:275380	7/24 (29%)
		leucine-rich repeat	293..322	CDD:275380	6/28 (21%)
		leucine-rich repeat	395..406	CDD:275378	1/10 (10%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..308	CDD:275380	7/20 (35%)
		leucine-rich repeat	309..334	CDD:275380	2/24 (8%)
		leucine-rich repeat	335..386	CDD:275380	9/50 (18%)
		leucine-rich repeat	388..408	CDD:275380	6/19 (32%)
		LRR_8	412..465	CDD:290566	20/60 (33%)
		leucine-rich repeat	412..432	CDD:275378	6/25 (24%)
		LRR_4	432..470	CDD:289563	15/39 (38%)
		leucine-rich repeat	433..454	CDD:275378	8/22 (36%)
		leucine-rich repeat	455..478	CDD:275378	5/22 (23%)
		leucine-rich repeat	479..490	CDD:275378	3/27 (11%)
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930