DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7800 and Lrrc15

DIOPT Version :9

Sequence 1:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_659551.1	Gene:	Lrrc15 / 246296	RGDID:	70551	Length:	578	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	119/512 - (23%)
Similarity:	194/512 - (37%)	Gaps:	110/512 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ATKLTEFHMDSCEKKVLKLMPNLRTLELENCDSPDFTMNDLNQLPY--------LTSLQLRRGNL 99
            |.|:.:..:.:......:.:.:||.|.|.|        |.|..||.        |.||.|....|
  Rat    81 ALKMEKNELSTIMPGAFRNLGSLRYLSLAN--------NKLRMLPIRVFQDVNNLESLLLSNNQL 137

  Fly   100 LGLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHL 164
            :.:....||::.|::.|.|.|||:..:..|.|..|..|..|:|..|....|...:||:|..|..|
  Rat   138 VQIQPAQFSQFSNLRELQLHGNNLESIPEEAFDHLVGLTKLNLGRNSFTHLSPRLFQHLGNLQVL 202

  Fly   165 DLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSN--CGPLPD---LS 224
            .|..||:..:....|..:..|:.|.|..|.:..::|....:..||:.|.:||  ...||.   :.
  Rat   203 RLHENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISQLPPGIFMQ 267

  Fly   225 LPGAHTLILDNSGVQRLD--ILG---SVHKLQARKNHITEIKLPDKSSVIELD---LHSNLLTAT 281
            ||..:.|.|..:.::.|.  :.|   ::.:|....||||.:.....|.:.:|.   |..|.||..
  Rat   268 LPQLNKLTLFGNSLRELSPGVFGPMPNLRELWLYNNHITSLADNTFSHLNQLQVLILSHNQLTYI 332

  Fly   282 DIPKLLTGMWRLQRLDLSENIIGIYAAAGSDNTSELF-ILPNLMYMNLSANRLTRLHFDSPIPWE 345
            . |....|:..|:.|.|..|.:       .|..|.:| .|.||..::|.:|||.:|.
  Rat   333 S-PGAFNGLTNLRELSLHTNAL-------QDLDSNVFRSLANLQNISLQSNRLRQLP-------- 381

  Fly   346 RLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELTPWKPHPSLKEVALYDNKFQPKGY 410
                     ..|:|...       .|.::.|:.|.:.|..|..:....:|.|:.||||.::..
  Rat   382 ---------GSIFANVN-------GLTTIQLQNNNLENLPLGIFDHLVNLCELRLYDNPWRCD-- 428

  Fly   411 KNITKFFNEIGVNVLEKTQYSQSNNTTPTCK------------------------------PCIP 445
            .:|....|.:.:|     :.....:|.|.|.                              |..|
  Rat   429 SDILPLHNWLLLN-----RARLGTDTLPVCSSPANVRGQSLVIININFPGPSVQGPETPEVPSYP 488

  Fly   446 DARDFP--TSISADTNQT------IDTKVNPLSNDTYQWNVWNV---LMLVSLIVSL 491
            |...:|  ||:|:.|..|      .|......::|...|.:...   |.:.::::.:
  Rat   489 DTPSYPDTTSVSSTTEITSAVDDYTDLTTIEATDDRNTWGMTEAQSGLAIAAIVIGI 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	0/17 (0%)
		leucine-rich repeat	65..85	CDD:275380	7/19 (37%)
		LRR_8	87..147	CDD:290566	21/67 (31%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	8/22 (36%)
		LRR_RI	<131..334	CDD:238064	60/216 (28%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		LRR_8	140..195	CDD:290566	17/54 (31%)
		leucine-rich repeat	161..184	CDD:275380	6/22 (27%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..246	CDD:275380	12/46 (26%)
		leucine-rich repeat	247..267	CDD:275380	5/19 (26%)
		leucine-rich repeat	268..292	CDD:275380	7/26 (27%)
		leucine-rich repeat	293..322	CDD:275380	8/29 (28%)
		leucine-rich repeat	395..406	CDD:275378	6/10 (60%)
Lrrc15	NP_659551.1	LRR_8	54..113	CDD:290566	8/39 (21%)
		LRR 1	54..75
		LRR 2	78..99		2/17 (12%)
		leucine-rich repeat	79..102	CDD:275380	2/20 (10%)
		LRR_RI	<94..303	CDD:238064	58/216 (27%)
		LRR_8	102..161	CDD:290566	21/66 (32%)
		LRR 3	102..123		9/28 (32%)
		leucine-rich repeat	103..126	CDD:275380	9/30 (30%)
		LRR 4	126..147		6/20 (30%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		LRR_8	149..209	CDD:290566	21/59 (36%)
		LRR 5	150..171		8/20 (40%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		LRR 6	174..195		6/20 (30%)
		leucine-rich repeat	175..198	CDD:275380	8/22 (36%)
		LRR_8	198..257	CDD:290566	16/58 (28%)
		LRR 7	198..219		6/20 (30%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
		LRR 8	222..243		5/20 (25%)
		leucine-rich repeat	223..246	CDD:275380	5/22 (23%)
		LRR_8	245..305	CDD:290566	15/59 (25%)
		LRR 9	246..267		7/20 (35%)
		leucine-rich repeat	247..270	CDD:275380	7/22 (32%)
		LRR 10	270..291		3/20 (15%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		LRR_8	293..353	CDD:290566	17/60 (28%)
		LRR 11	294..315		5/20 (25%)
		leucine-rich repeat	295..318	CDD:275380	6/22 (27%)
		LRR_4	318..358	CDD:289563	12/47 (26%)
		LRR 12	318..339		6/21 (29%)
		leucine-rich repeat	319..342	CDD:275380	7/23 (30%)
		LRR 13	342..363		7/27 (26%)
		leucine-rich repeat	343..364	CDD:275380	7/27 (26%)
		LRR_8	366..424	CDD:290566	19/81 (23%)
		LRR 14	366..387		8/37 (22%)
		leucine-rich repeat	367..387	CDD:275380	7/36 (19%)
		LRR 15	390..411		5/20 (25%)
		leucine-rich repeat	391..412	CDD:275380	5/20 (25%)
		TPKR_C2	423..>462	CDD:301599	7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..500		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010