DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7800 and lron-11

DIOPT Version :9

Sequence 1:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_491035.1	Gene:	lron-11 / 171837	WormBaseID:	WBGene00022129	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	113/361 - (31%)
Similarity:	171/361 - (47%)	Gaps:	49/361 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LLGRSRTFSDKKATKLTEFHMDSCEKKVLKLMPNLRTLELENCDSPDFTMNDLNQLPYLTSLQLR 95
            ||....|..|....:::....|.     |.|.|||..|.|.|......:.:..:.||.|..|.|.
Worm    43 LLDPRTTVLDLSNNRISRLSADE-----LSLYPNLEQLILHNNSITHLSADVFSTLPSLRVLDLS 102

  Fly    96 RGNLLGLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPE 160
            ..:||.|.:|.|||..|:|.|::..|:: :|..|||.||:||..||:..|.:..||..|.:.|..
Worm   103 SNSLLSLPNEVFSKLKNLKTLIISSNDV-QLGPECFAGLSQLQTLSIADNRLSFLPPSVLKPLSG 166

  Fly   161 LLHLDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSN--CGPLPDL 223
            |.:||||.|::.::..::...:..||.|.|..|.|:.:......|...|:.||:|.  .|.:.:.
Worm   167 LRNLDLSANKLLSMPASVMNNLGGLETLKLKQNLLSSLETGMFLSQKELKHLDVSENLIGDIEEG 231

  Fly   224 SLPG---AHTLILDNSGVQRLDILGSVHKLQARKNHITEIKLPDKSSVIELDLHSNLLTATDIPK 285
            :|.|   ..||.|.|:.:.||.  |:...|.|.|.               |||.|||..:.:...
Worm   232 ALYGLEKLETLNLTNNQLVRLP--GNTWSLPALKT---------------LDLSSNLFVSLETAS 279

  Fly   286 LLTGMWRLQRLDL--SENIIGIYAAAGSDNTSELFI-LPNLMYMNLSANRLTRLHFD--SPIPWE 345
             ..|:..||.|::  |.|:..|..|.        |: |.:|.::::|::.||.:|..  :|||
Worm   280 -FDGLPALQYLNISHSRNLKTIQMAT--------FVQLSSLHWLSISSSALTHIHPSAFNPIP-- 333

  Fly   346 RLTHLDASYN--RIYAPAKVGIDEAFNLQSLHLEGN 379
            .|:|||.|.|  |..||   |:.:..|:::|||..|
Worm   334 PLSHLDLSNNELRYVAP---GMLQWPNIRNLHLANN 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	3/17 (18%)
		leucine-rich repeat	65..85	CDD:275380	4/19 (21%)
		LRR_8	87..147	CDD:290566	26/59 (44%)
		leucine-rich repeat	89..112	CDD:275380	10/22 (45%)
		leucine-rich repeat	113..136	CDD:275380	9/22 (41%)
		LRR_RI	<131..334	CDD:238064	60/210 (29%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		LRR_8	140..195	CDD:290566	18/54 (33%)
		leucine-rich repeat	161..184	CDD:275380	6/22 (27%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..246	CDD:275380	13/41 (32%)
		leucine-rich repeat	247..267	CDD:275380	3/19 (16%)
		leucine-rich repeat	268..292	CDD:275380	7/23 (30%)
		leucine-rich repeat	293..322	CDD:275380	9/31 (29%)
		leucine-rich repeat	395..406	CDD:275378
lron-11	NP_491035.1	leucine-rich repeat	48..71	CDD:275380	5/27 (19%)
		LRR_RI	<50..177	CDD:238064	47/132 (36%)
		LRR_8	70..130	CDD:290566	22/59 (37%)
		leucine-rich repeat	72..95	CDD:275380	5/22 (23%)
		leucine-rich repeat	96..119	CDD:275380	10/22 (45%)
		LRR_8	118..177	CDD:290566	25/59 (42%)
		leucine-rich repeat	120..142	CDD:275380	9/22 (41%)
		LRR_RI	<141..270	CDD:238064	42/145 (29%)
		leucine-rich repeat	143..166	CDD:275380	8/22 (36%)
		leucine-rich repeat	167..190	CDD:275380	6/22 (27%)
		LRR_8	190..249	CDD:290566	18/58 (31%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		LRR_8	238..295	CDD:290566	20/74 (27%)
		leucine-rich repeat	239..261	CDD:275380	8/23 (35%)
		leucine-rich repeat	262..283	CDD:275380	7/36 (19%)
		LRR_8	284..345	CDD:290566	23/70 (33%)
		leucine-rich repeat	286..310	CDD:275380	9/31 (29%)
		leucine-rich repeat	311..334	CDD:275380	8/24 (33%)
		leucine-rich repeat	335..357	CDD:275380	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010