DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7800 and slitrk5b

DIOPT Version :9

Sequence 1:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_002667367.2	Gene:	slitrk5b / 100331252	ZFINID:	ZDB-GENE-110408-55	Length:	856	Species:	Danio rerio

Alignment Length:	678	Identity:	130/678 - (19%)
Similarity:	226/678 - (33%)	Gaps:	276/678 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 CDSPD--FTMN----DLNQLPYLTSLQ------LRRGNLL---GLHDEHFSKWPNMKILMLGGNN 122
            |:..|  ||.:    .:|.|..:|.|.      |..||||   .|:|  |..:..:.||.||.|:
Zfish    49 CEERDGIFTASCENRGINSLSEVTPLHFTAYHLLLTGNLLKKVSLND--FLHYEGLTILHLGNND 111

  Fly   123 ITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIETLHENIFTGVPKLEM 187
            |..:....|             ||:|||.           .|.|:.|:||.|.::.|.|:..||.
Zfish   112 ICEIEAGAF-------------NGLQGLK-----------RLHLNNNKIEALKDDTFLGLESLEY 152

  Fly   188 LLLNGNPLTWIAPTSLKSLSNLRLLDMSN------------CGPLPDLSLPGAHTLILDNSGVQR 240
            |.::.|.::.|.|.:|.:|.:|.:|.:::            ..||..|.|.|....:|..||:
Zfish   153 LQIDYNYISHIEPNALSALRHLEVLILNDNLLSALPHNIFQYVPLTHLDLRGNQLKVLPYSGL-- 215

  Fly   241 LDILGSVHKLQARKN-----------------------------------------HITEIKLPD 264
            |:.|..:.:||..:|                                         .|::.:|..
Zfish   216 LEHLSRIVELQLEENAWNCSCELIALKTWLESISYTALVGDVVCETPFRLHGRDLDEISKQELCP 280

  Fly   265 KSSVIELDLH----------------------SNLLTAT-------------------------- 281
            :.::.|.::|                      |.:|.:|
Zfish   281 RRAIAEYEMHAEMAHSSETVSKTTPATAGFASSTILRSTKSSRLSGKLRVKPTSRSSSSKPQNYG 345

  Fly   282 -------------DIPKLLTGMWRLQRLDLSENIIGIYAAAGSD------NTSELFILPN----- 322
                         |.|...|...::..|.|:.|.......:.||      |..::::..|
Zfish   346 PMLAYQTKSPVPLDCPNTCTCNLQISDLGLNVNCQERKIESISDLDPKPYNPKKMYLTGNYISSV 410

  Fly   323 ----------LMYMNLSANR--------------LTRLHFDSPIPWERLTHLDASY--------- 354
                      |..::|..||              |.||:.:..: .||||. |..|
Zfish   411 CSSDFSGATGLDLLHLGNNRIAVVHDKTFGQLIHLRRLYLNGNL-IERLTE-DMFYGLQSLQFLY 473

  Fly   355 --------------------------NRIYAPAKVGIDEAFNLQSLHLEGNYINNF-------EL 386
                                      |.:.....:||.:..||..|:|..|:....       ||
Zfish   474 LEYNVIREIAVGTFQQLPNLQLLFLNNNLLKTLHLGIFDGLNLARLNLRSNHFRTLPVIGVLDEL 538

  Fly   387 TPWKPHPSLKEVALYDNKFQPK-GYKNITKFFNEIG----VNVL----------EKTQYSQSNNT 436
            .      ||.::.|::|.:... ...::..:..::.    ||.:          |..:|.:|::.
Zfish   539 A------SLIQIDLFENPWDCSCSILDMKNWLEQLSAGTVVNTVICESPPRLSGEDMRYIRSSHI 597

  Fly   437 TP-------TCKPCIPDARDFP-TSISADTNQTIDTK--VNPLSNDTYQWNVWNVLMLVSLIVSL 491
            .|       :..|  |....|| ::|:.:|....||:  ..|||       |..:.:|:..|:|:
Zfish   598 CPESSIAQSSAVP--PSEESFPGSTITLETALDFDTQYPAVPLS-------VLILALLLLFILSV 653

  Fly   492 FVNSFLIVKLIRLRGRNQFTQSSSVPAI 519
            |:.:.|...:::.|.:::.:.|.:..||
Zfish   654 FIAAGLFAVIMKRRKKSERSASVTASAI 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380
		leucine-rich repeat	65..85	CDD:275380	4/17 (24%)
		LRR_8	87..147	CDD:290566	18/68 (26%)
		leucine-rich repeat	89..112	CDD:275380	10/31 (32%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	<131..334	CDD:238064	58/351 (17%)
		leucine-rich repeat	137..160	CDD:275380	5/22 (23%)
		LRR_8	140..195	CDD:290566	17/54 (31%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..246	CDD:275380	12/48 (25%)
		leucine-rich repeat	247..267	CDD:275380	5/60 (8%)
		leucine-rich repeat	268..292	CDD:275380	8/84 (10%)
		leucine-rich repeat	293..322	CDD:275380	6/34 (18%)
		leucine-rich repeat	395..406	CDD:275378	3/10 (30%)
slitrk5b	XP_002667367.2	LRR_8	79..136	CDD:290566	23/82 (28%)
		leucine-rich repeat	80..101	CDD:275380	8/22 (36%)
		LRR_RI	<101..283	CDD:238064	45/207 (22%)
		leucine-rich repeat	102..125	CDD:275380	9/35 (26%)
		LRR_8	125..184	CDD:290566	20/69 (29%)
		leucine-rich repeat	126..149	CDD:275380	9/33 (27%)
		leucine-rich repeat	150..173	CDD:275380	8/22 (36%)
		LRR_8	172..230	CDD:290566	14/59 (24%)
		leucine-rich repeat	174..189	CDD:275380	2/14 (14%)
		leucine-rich repeat	197..221	CDD:275380	9/25 (36%)
		leucine-rich repeat	222..367	CDD:275380	13/144 (9%)
		LRRCT	230..>268	CDD:214507	1/37 (3%)
		leucine-rich repeat	368..420	CDD:275380	7/51 (14%)
		leucine-rich repeat	376..397	CDD:275380	3/20 (15%)
		LRR_8	419..479	CDD:290566	13/61 (21%)
		leucine-rich repeat	421..444	CDD:275380	4/22 (18%)
		LRR_4	444..482	CDD:289563	9/39 (23%)
		leucine-rich repeat	445..468	CDD:275380	9/24 (38%)
		leucine-rich repeat	469..488	CDD:275380	0/18 (0%)
		leucine-rich repeat	493..515	CDD:275380	3/21 (14%)
		leucine-rich repeat	516..540	CDD:275380	6/29 (21%)
		LRRCT	549..599	CDD:214507	6/49 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000