DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grn and TRPS1

DIOPT Version :9

Sequence 1:	NP_001262366.1	Gene:	grn / 40962	FlyBaseID:	FBgn0001138	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_054831.2	Gene:	TRPS1 / 7227	HGNCID:	12340	Length:	1294	Species:	Homo sapiens

Alignment Length:	723	Identity:	153/723 - (21%)
Similarity:	221/723 - (30%)	Gaps:	192/723 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GGSSGGGNGGGVSPQTNGLGSAGSSLAHSHHSLSSGASSAGSSVGVGSALGGGGGSGLDTSDMSA 87
            |...|....||::|:.|...|.||.:..:        ..|.||.|..........||....|.|
Human   469 GKQHGAVQSGGLNPELNDKLSRGSVINQN--------DLAKSSEGETMTKTDKSSSGAKKKDFS- 524

  Fly    88 FYALESNGHHRRYYPSYHQHTSRMPSTHASPQVCRPHF---HTP----LSPWL------------ 133
                 |.|.......||            :.|.|...:   |.|    :.|.|
Human   525 -----SKGAEDNMVTSY------------NCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKC 572

  Fly   134 TSEHKSFAPASAWS----MGQ----FACPQEPQVEH--------KLGQMGQSHQTTAAGQHSFPF 182
            |.:|..|.|....|    :|:    ||| ::....|        ..|..|.|.......|.||
Human   573 TIKHCPFCPRGLCSPEKHLGEITYPFAC-RKSNCSHCALLLLHLSPGAAGSSRVKHQCHQCSF-- 634

  Fly   183 PPTPPKDSTPDSVQTGPSEYQAVMNAFMHQQATGSTSLTDASCALDIKPSIQNGSASGSSGSGTT 247
                   :||| |......|::|     |:           |.|.|:|.     .|:...||
Human   635 -------TTPD-VDVLLFHYESV-----HE-----------SQASDVKQ-----EANHLQGS--- 667

  Fly   248 HTSTPKQREGTASTTNSSSNSSSSQQ---QQQQQQQQQQQQQQSSSNTTASSNTSASSSAAAASL 309
                    :|..|...|..:|.:...   |.:::..:..::..|.......|.|:|.:.:.....
Human   668 --------DGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHF 724

  Fly   310 SAA-VAASAATSSNGLFDGTAQAYSSGGSGGGGGGGSGSGGYDTSSYASYHHAAA---HHQAAAV 370
            :.. ......|::||..||                                ||.:   .......
Human   725 NTVHCQEQDITTANGEEDG--------------------------------HAISTIKEEPKIDF 757

  Fly   371 AAANMFQSSSVAAAAVRHSMAAAQAHHHHHHHHSGHHHSGSSSGLHGLGGSVGGTAGMGSMSGNS 435
            ...|:....|.....|..|:...:................||..|..:... |.....||.|...
Human   758 RVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWR-GADILRGSPSYTQ 821

  Fly   436 GGAGSLSGHSGAGSNAGSNCLDVKPVRTKPRTSAE--GRECVNCGATSTPLWRRDGTGHYLCNAC 498
            ...|.|:..||...       ..|.:|..|...|.  .|........:....:....|.....|.
Human   822 ASLGLLTPVSGTQE-------QTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGAL 879

  Fly   499 GLYYKMNGQNRPLIKPKRRLTLQSLQSAAKRAGTSCANCKTTTTTLWRRNASGEPVCNACGLYYK 563
            ...|..:|:|      |.:...|||....:.:|..||||.||.|:|||:||:|..||||||||.|
Human   880 PQQYPASGEN------KSKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGGYVCNACGLYQK 938

  Fly   564 LHNVNRPLTMKKEG-----IQTRNRK------LSSKSKKKKGLGGGCLPIGGHLGMGDFKPLDPS 617
            ||:..|||.:.|:.     |:.|.||      |.::...|:..|.....:.|       .||:
Human   939 LHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSNEEQVNG-------SPLE-- 994

  Fly   618 KGFGGGFSASMAQHGHLSSGLHPAHAHMHGSWYTGGMGALGASSGLQGGFSTAGSLSGAVVPHSQ 682
                      .....||:.. |.....:.........|:|..|...|.....:.:|.  :....|
Human   995 ----------RRSEDHLTES-HQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQTLD--IHKRMQ 1046

  Fly   683 PYHLGLSS 690
            |.|:.:.|
Human  1047 PLHIQIKS 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grn	NP_001262366.1	ZnF_GATA	470..517	CDD:214648	7/48 (15%)
		ZnF_GATA	473..517	CDD:238123	6/43 (14%)
		ZnF_GATA	529..578	CDD:214648	29/53 (55%)
		ZnF_GATA	533..583	CDD:238123	30/54 (56%)
TRPS1	NP_054831.2	ZnF_GATA	904..947	CDD:214648	27/42 (64%)
TRPS1	NP_054831.2	ZnF_GATA	908..964	CDD:238123	30/55 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810