Protein Alignment grn and Gata2

DIOPT Version :9

• Sequence 1: NP_001262366.1
• Gene: grn / 40962
• FlyBaseID: FBgn0001138
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_001342182.1
• Gene: Gata2 / 14461
• MGIID: 95662
• Length: 480
• Species: Mus musculus
• Alignment Length: 629
• Identity: 207/629 - (32%)
• Similarity: 255/629 - (40%)
• Gaps: 258/629 - (41%)

  Fly    83 SDMSAFYALESNGHHRRYYPSYHQHTSRMPSTHASPQVCRPH-FHTPLSPWLTSEHKSFAPASA- 145
            |..:.:||   |..|.|...||....:|:    ...|:|||| .|:|..|||.....:.:.|:|
Mouse    54 SQGNPYYA---NPAHARARVSYSPAHARL----TGGQMCRPHLLHSPGLPWLDGGKAALSAAAAH 111

  Fly   146 ----WSMGQFA-CPQEPQVEHKL------------GQMGQSHQTTA--------AGQHSFPFPPT 185
                |::..|: .|..|......            |..|.|..:.|        :|.|.|.||||
Mouse   112 HHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPT 176

  Fly   186 PPKDSTPDSVQTGPSEYQAVMNAFMHQQATGSTSLTDASCALDIKPSIQNGSASGSSGSGTTHTS 250
            |||:.:||                                     ||             ||
Mouse   177 PPKEVSPD-------------------------------------PS-------------TT--- 188

  Fly   251 TPKQREGTASTTNSSSNSSSSQQQQQQQQQQQQQQQQSSSNTTASSNTSASSSAAAASLSAAVAA 315
                  |.||..:||:..|.::.:.:...:.|                        .|||.::.
Mouse   189 ------GAASPASSSAGGSVARGEDKDGVKYQ------------------------VSLSESMK- 222

  Fly   316 SAATSSNGLFDGTAQAYSSGGS----GGGGGGGSGSGGYDTSSYASYHHAAAHHQAAAVAAANMF 376
                             ..|||    |....|...:..:...:|.||..||||..
Mouse   223 -----------------MEGGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDY---------- 260

  Fly   377 QSSSVAAAAVRHSMAAAQAHHHHHHHHSGHHHSGSSSGLHGLGGSVGGTAGMGSMSGNSGGAGSL 441
                                             |||  |...||.:||.|  .|.:...
Mouse   261 ---------------------------------GSS--LFHPGGFLGGPA--SSFTPKQ------ 282

  Fly   442 SGHSGAGSNAGSNCLDVKPVRTKPRTSAEGRECVNCGATSTPLWRRDGTGHYLCNACGLYYKMNG 506
                                |:|.|:.:|||||||||||:||||||||||||||||||||:||||
Mouse   283 --------------------RSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNG 327

  Fly   507 QNRPLIKPKRRLTLQSLQSAAKRAGTSCANCKTTTTTLWRRNASGEPVCNACGLYYKLHNVNRPL 571
            ||||||||||||      |||:||||.||||:|||||||||||:|:|||||||||||||||||||
Mouse   328 QNRPLIKPKRRL------SAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPL 386

  Fly   572 TMKKEGIQTRNRKLSSKSKKKKGLGGGCL-----------------PIGGHLG-MGDFKPLDPSK 618
            |||||||||||||:||||||.| .|..|.                 .:.||:. :|...|
Mouse   387 TMKKEGIQTRNRKMSSKSKKSK-KGAECFEELSKCMQEKSPPFSAAALAGHMAPVGHLPP----- 445

  Fly   619 GFGGGFSASMAQHGHL---SSGLHPAHA----HMHGSWYTGGMG 655
                 ||.|    ||:   .:.:||:.:    |.|.|.....||
Mouse   446 -----FSHS----GHILPTPTPIHPSSSLSFGHPHPSSMVTAMG 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grn	NP_001262366.1	ZnF_GATA	470..517	CDD:214648	44/46 (96%)
		ZnF_GATA	473..517	CDD:238123	41/43 (95%)
		ZnF_GATA	529..578	CDD:214648	44/48 (92%)
		ZnF_GATA	533..583	CDD:238123	45/49 (92%)
Gata2	NP_001342182.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..208		22/100 (22%)
		ZnF_GATA	294..344	CDD:238123	47/55 (85%)
		ZnF_GATA	349..398	CDD:238123	45/48 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..480		5/22 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8413
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2843
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1240204at2759
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		otm44273
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	1	1.000	-	-		X385
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.960