DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9667 and ISY1-RAB43

DIOPT Version :9

Sequence 1:	NP_649768.2	Gene:	CG9667 / 40960	FlyBaseID:	FBgn0037550	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_001191819.1	Gene:	ISY1-RAB43 / 100534599	HGNCID:	42969	Length:	331	Species:	Homo sapiens

Alignment Length:	275	Identity:	167/275 - (60%)
Similarity:	209/275 - (76%)	Gaps:	8/275 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARNAEKAMTTLARWRAAKEVESGEKERRPYLASECHDLPRCEKFRLEIIRDISKKVAQIQNAGL 65
            ||||||||||.|||:|.|:..|...|||||:|||||.:||:.||:|.:||.:|||||||||||||
Human     1 MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGL 65

  Fly    66 GEFRIRDLNDEINKLLREKRHWENQISSLGGPHYRRYGPKMFDAEGREVPGNRGYKYFGAAKDLP 130
            |||||||||||||||||||.|||.:|..||||.|.:.||||.|.||:||||||||||||||||||
Human    66 GEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLP 130

  Fly   131 GVRELFEQDPPPPPRKSRAELMKDIDAEYYGYRDDEDGVLIPLEERIERAAIQKAVQEWR----E 191
            |||||||::|.|||||:||||||.||.|||||.|::|||::|||:..|:....:.|::|:    .
Human   131 GVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREA 195

  Fly   192 KMARDGRIIDDEEEDEIYPLSGPAREAIEDAKARAAVEDPHGLLASKFTAHVPVPTQQDVQEALL 256
            ::||..:..::|||:||...:....|:.|:.......:|..    .||.||||||:||:::|||:
Human   196 RLARGEKEEEEEEEEEINIYAVTEEESDEEGSQEKGGDDSQ----QKFIAHVPVPSQQEIEEALV 256

  Fly   257 RQRKRELLEKYAGGT 271
            |::|.|||:|||..|
Human   257 RRKKMELLQKYASET 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9667	NP_649768.2	Isy1	1..266	CDD:283825	163/268 (61%)
ISY1-RAB43	NP_001191819.1	Isy1	1..266	CDD:283825	163/268 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159142
Domainoid	1	1.000	324	1.000	Domainoid score	I1210
eggNOG	1	0.900	-	-		E1_KOG3068
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6283
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2453
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55550
OrthoDB	1	1.010	-	-		D1513531at2759
OrthoFinder	1	1.000	-	-		FOG0004185
OrthoInspector	1	1.000	-	-		oto89520
orthoMCL	1	0.900	-	-		OOG6_102669
Panther	1	1.100	-	-	LDO	PTHR13021
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R622
SonicParanoid	1	1.000	-	-		X2932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800