Protein Alignment CG7878 and DDX46

DIOPT Version :10

• Sequence 1: NP_649767.1
• Gene: CG7878 / 40959
• FlyBaseID: FBgn0037549
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_001287789.1
• Gene: DDX46 / 9879
• HGNCID: 18681
• Length: 1032
• Species: Homo sapiens
• Alignment Length: 770
• Identity: 245/770 - (31%)
• Similarity: 367/770 - (47%)
• Gaps: 142/770 - (18%)

  Fly    25 NNKYERSIRRD---GNSRAYKGDRNDYGGEGRGYRAKRNDYGGGRRDNRDNYGAGHRDSRDSAGG 86
            :.:.|||..||   ..||..|..|.....|....|.:|......||.:|.. ..|.| ||.|:.|
Human    46 DRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSR-SRGRR-SRSSSPG 108

  Fly    87 GGGDFSESLSIASEMVGKVIGRGGSNISRIQNDFNVRVKLDKCDLIVKITGSIQSNVIDAINHVR 151
            .....:|:.|.:.|...     ||.:....:.|     |.||.|...|..|:...|.::.....|
Human   109 NKSKKTENRSRSKEKTD-----GGESSKEKKKD-----KDDKEDEKEKDAGNFDQNKLEEEMRKR 163

  Fly   152 KQ-------------VTNSGD----------------RGQDRDNRDHGSNER------------- 174
            |:             :.|.|:                ...|.|..|....|:
Human   164 KERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPL 228

  Fly   175 ------------------YDGGGYDRYKGNSYEFNPTSS-------------ESNKDNGDL---- 204
                              ..|||     ||..:..||.:             :|:|..|:|
Human   229 DAYMEEVKEEVKKFNMRSVKGGG-----GNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMEND 288

  Fly   205 ----------------TGIIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIERI 253
                            |.:..::...:..:........:..|..||||.|.||:|.:::.|:...
Human   289 QDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVF 353

  Fly   254 REENNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPDMLEEITKMGFSKPSPIQSQAWPILL 318
            |.|...|||.          ....|.|:.::.||.... .:|..:.|.|:.||:|||:||.|.::
Human   354 RLEMEGITVK----------GKGCPKPIKSWVQCGISM-KILNSLKKHGYEKPTPIQTQAIPAIM 407

  Fly   319 QGHDMIGIAQTGTGKTLAFLLPGMIH-TEYQSTPRGTRGGANVLVLAPTRELALQIEMEVKKYS- 381
            .|.|:||||:||:|||:|||||...| .:.:|...|.  |...:::.|||||||||..|.||:|
Human   408 SGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGE--GPIAVIMTPTRELALQITKECKKFSK 470

  Fly   382 FRGMKAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMAN---VIDVSTITYLVLDEADRML 443
            ..|::.||||||...:.||::|:||||||:|||||:.|::.||   |.::..:||:||||||||.
Human   471 TLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMF 535

  Fly   444 DMGFEPQIRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAATHSVKQIIKL 508
            |||||||:.:::.::||||||:|.|||:|..:..||:..:..||:|.||...:..:...:|:|.:
Human   536 DMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVI 600

  Fly   509 MEDDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIA 573
            .|:  .||..:...:.:...:..:|||..::..||.|..:|....:....:||..||.||:..|.
Human   601 EEE--KKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIIN 663

  Fly   574 DIKSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDW 638
            |.|:|..::||||.||:||||::.:..|:||..|::.|:||||.|||||||.:|.:.:|.|.:..
Human   664 DFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQA 728

  Fly   639 AMAKELIEILQEAEQEVPDELHNMARRFKAMKDKRAAEG------GGFGGRGGRF 687
            ..|.::|:.|:.:...||.:|..:...|   ||::.|||      .||.|:|.:|
Human   729 RYAGDIIKALELSGTAVPPDLEKLWSDF---KDQQKAEGKIIKKSSGFSGKGFKF 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH_1	92..152	CDD:459630	13/59 (22%)
		DEAD-like_helicase_N	174..663	CDD:475120	192/557 (34%)
DDX46	NP_001287789.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..228		42/193 (22%)
		DEADc_DDX46	361..582	CDD:350711	107/233 (46%)
		Q motif	372..400		9/28 (32%)
		SrmB	378..793	CDD:440279	172/411 (42%)
		DEAD box	529..532		2/2 (100%)
		KH-I_DDX46	929..1031	CDD:411901