Protein Alignment CG7878 and DDX23

DIOPT Version :10

• Sequence 1: NP_649767.1
• Gene: CG7878 / 40959
• FlyBaseID: FBgn0037549
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_004809.2
• Gene: DDX23 / 9416
• HGNCID: 17347
• Length: 820
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 236/797 - (29%)
• Similarity: 355/797 - (44%)
• Gaps: 197/797 - (24%)

  Fly    22 SKPNNKYERSIRRDGNSRAYKGDRNDYGGEGRGYRAKRNDYGGGR-RDNRDNYGAGHRDSRDS-- 83
            ||...::....||.|.||:....|:......|.::.:..|....| :.:||....|||..:|.
Human    41 SKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKR 105

  Fly    84 ---AGGGGGDF----------------------SESLSIASEMVGKVIGRGGSNISRIQNDFNVR 123
               :.|.|.||                      ::.||: .|::.|         .:.:.:...:
Human   106 SSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSL-EELLAK---------KKAEEEAEAK 160

  Fly   124 VK-LDKCDLIVKITGSIQSNV------IDAINHVRKQVTNSG----DRGQDRDNRD--------- 168
            .| |.|.:...:.....|..|      ::.....|||..:.|    :..|:|:.|:
Human   161 PKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERET 225

  Fly   169 ----------------------HGSNERYDGG-----------------GYDRYKGNSYEFNPTS 194
                                  |...|||.||                 .:|..:..|.::||..
Human   226 NGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLY 290

  Fly   195 SESNK----DNGDLTGIIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIE---- 251
            .|.::    ..|.:.| ||.:...:...........|...|.:...:|| .:..|.|.|.:
Human   291 KERHQVQLLGRGFIAG-IDLKQQKREQSRFYGDLMEKRRTLEEKEQEEA-RLRKLRKKEAKQRWD 353

  Fly   252 -----------------RIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPDMLEEIT 299
                             ||..|:..||.      |.|:    ||||:.:::..... |.:||.|.
Human   354 DRHWSQKKLDEMTDRDWRIFREDYSITT------KGGK----IPNPIRSWKDSSLP-PHILEVID 407

  Fly   300 KMGFSKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRGTR-----GGAN 359
            |.|:.:|:|||.||.||.||..|:||:|:||:|||.|||:|.::.  ..:.|:..|     .|..
Human   408 KCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVW--ITTLPKIDRIEESDQGPY 470

  Fly   360 VLVLAPTRELALQIEMEVKKYSF-RGMKAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMA 423
            .::||||||||.|||.|..|:.. .|::.|.|.||.:|..|...|..|.||:|.|||||.|::..
Human   471 AIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLEN 535

  Fly   424 NVIDVSTITYLVLDEADRMLDMGFEPQIRKVMLDI-----RPD---------------------R 462
            ..:.:|..||:||||||||:||||||.::|::..:     :||                     |
Human   536 RYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR 600

  Fly   463 QTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLD------------LAATHSVKQIIKLMEDDMDK 515
            ||:|.:||.||.|.|||:||::.|..|.:||..            ::.:...|:::.::|...|
Human   601 QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFD- 664

  Fly   516 FNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSGVV 580
                          ..||||..:|...|.|:..|...|:....:||.:.|..||.|::::|:|..
Human   665 --------------PPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAK 715

  Fly   581 RILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKELI 645
            .||||||||.||:||:|::.|:|||...|||:|:||:|||||||:.|.:|:|.|:||.|:..||.
Human   716 DILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK 780

  Fly   646 E-ILQEAEQEVPDELHN 661
            : ||:......|.||.|
Human   781 QAILESPVSSCPPELAN 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH_1	92..152	CDD:459630	9/66 (14%)
		DEAD-like_helicase_N	174..663	CDD:475120	197/575 (34%)
DDX23	NP_004809.2	RS domain	1..221		37/189 (20%)
		PTZ00121	<4..>351	CDD:173412	59/321 (18%)
		SF-CC1	80..>209	CDD:273721	25/138 (18%)
		Q motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00552	391..419		9/28 (32%)
		SrmB	392..783	CDD:440279	160/408 (39%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	549..552		2/2 (100%)