DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7878 and DBP2

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_014287.3	Gene:	DBP2 / 855611	SGDID:	S000005056	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	568	Identity:	248/568 - (43%)
Similarity:	342/568 - (60%)	Gaps:	68/568 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 TNSGDRGQD----RDNRDHGSNERYDGGGYDRYKGNSYEFNPTSSESNKDNGDLTGIIDWEALNK 215
            ||...||.|    |::..:..|:|..||.|....|....:| ...|..|.|.|       |.|
Yeast    13 TNYKSRGGDFRGGRNSDRNSYNDRPQGGNYRGGFGGRSNYN-QPQELIKPNWD-------EEL-- 67

  Fly   216 ASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIERIREENNKITVSYVFEPKEGETSPPIPNP 280
                      .|.|...||||.|...|.:.:.|||.:.|:| |::|:|          ...||.|
Yeast    68 ----------PKLPTFEKNFYVEHESVRDRSDSEIAQFRKE-NEMTIS----------GHDIPKP 111

  Fly   281 VWTFEQCFAEYPD-MLEEITKMGFSKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGMIH 344
            :.||::  |.:|| :|.|:...||.||:.||.|.||:.|.|.||:|||.||:||||::.|||::|
Yeast   112 ITTFDE--AGFPDYVLNEVKAEGFDKPTGIQCQGWPMALSGRDMVGIAATGSGKTLSYCLPGIVH 174

  Fly   345 TEYQSTPRGTRG-GANVLVLAPTRELALQIEMEVKKYSFRG-MKAVCVYGGGNRNMQISDLERGA 407
            ...|  |....| |..|||||||||||:||:.|..|:.... ::..|||||..::.||.||.||:
Yeast   175 INAQ--PLLAPGDGPIVLVLAPTRELAVQIQTECSKFGHSSRIRNTCVYGGVPKSQQIRDLSRGS 237

  Fly   408 EIIICTPGRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEPQIRKVMLDIRPDRQTIMTSATWP 472
            ||:|.|||||.|::.....::..:||||||||||||||||||||||::..|||||||:|.|||||
Yeast   238 EIVIATPGRLIDMLEIGKTNLKRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWP 302

  Fly   473 PGVRRLAQSYMKNPIQVCVGSLDLAATHSVKQIIKLMEDDMDKFNTITSFVKNMSSTD--KIIIF 535
            ..|::||..|:.:||||.||||:|:|:|::.||:::: .|.:|.:.:..:::..|..:  |.:||
Yeast   303 KEVKQLAADYLNDPIQVQVGSLELSASHNITQIVEVV-SDFEKRDRLNKYLETASQDNEYKTLIF 366

  Fly   536 CGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITH 600
            ...|...||::..|..||:....|||::||.:|:..:.:.::|...|:||||||:||:|::.|.:
Yeast   367 ASTKRMCDDITKYLREDGWPALAIHGDKDQRERDWVLQEFRNGRSPIMVATDVAARGIDVKGINY 431

  Fly   601 VINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKELIEILQEAEQEVPDELHNMARR 665
            |||||.|.|||:||||:|||||||..||:|||||.::..:..:||.|::||.|.:|.||
Yeast   432 VINYDMPGNIEDYVHRIGRTGRAGATGTAISFFTEQNKGLGAKLISIMREANQNIPPEL------ 490

  Fly   666 FKAMKDKRAAEGGGF----GGRGGR--------FGGGRG--GGRRNFD 699
               :|..|.:.|||.    ||||||        :|||||  ||.|..|
Yeast   491 ---LKYDRRSYGGGHPRYGGGRGGRGGYGRRGGYGGGRGGYGGNRQRD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053
		DEADc	288..489	CDD:238167	111/203 (55%)
		DEXDc	298..505	CDD:214692	115/208 (55%)
		Helicase_C	514..624	CDD:278689	47/111 (42%)
DBP2	NP_014287.3	PTZ00110	4..492	CDD:240273	228/523 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I2717
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860