DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7878 and ddx43

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_001072473.1	Gene:	ddx43 / 779928	XenbaseID:	XB-GENE-988016	Length:	666	Species:	Xenopus tropicalis

Alignment Length:	699	Identity:	315/699 - (45%)
Similarity:	431/699 - (61%)	Gaps:	76/699 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DWDDPNYVEKPAVHQEYS----KPNNKYERSIRRDGNSRAYKGDRNDYGGEGRGYRAKRNDYGGG 65
            ||::.:..........|:    .|:.:|.|...|......:.|.|.|            ||.|||
Frog     3 DWEEESDSSSNQAAARYNTPWVPPSKQYSREEPRTKTQSEFCGWRED------------NDDGGG 55

  Fly    66 RRDNRDNYGAGHRDSRDSAGG-------------GGGDFSESL--SIASEMVGKVIGRGGSNISR 115
            |  :|...|:....||....|             |..|.|..|  .:.|..:|:|||||||.|..
Frog    56 R--SRSEQGSWRGFSRPRGSGPPGASTREFRRREGARDQSSPLCFHLDSSAIGQVIGRGGSKIRE 118

  Fly   116 IQNDFNVRVKLDKCDL--IVKITGSIQ-----SNVIDAINHVRKQVTNSGDRGQDRDNRDHGSNE 173
            ::.....|:|::|.|.  .|||.|:.:     ..:||       .:....:||.       |...
Frog   119 LEELSGCRIKIEKLDYDSEVKIYGNSEQQQKAKELID-------DIVEQSERGP-------GFKG 169

  Fly   174 RYDGGGYDRYKGNSYEFNPTSSESNKDNGDLTGIIDWEALNKASIAATAARWSKCPPLTKNFYKE 238
            ....|..|:....|::..|:              |:|.:|.:......|.:|:..||:.|.||||
Frog   170 FRSSGSADKSADASFQVKPS--------------INWASLRENKSKYEAMKWADMPPIAKAFYKE 220

  Fly   239 APEVANLTKSEIERIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPDMLEEITKMGF 303
            :||||::::.|:|:.|:|||.|....:.|.|..     |||||..||..|..:|:::..:.|.||
Frog   221 SPEVASMSRDEVEKWRKENNNIICDDLKEEKRS-----IPNPVPRFEDAFHPFPEVMSALEKSGF 280

  Fly   304 SKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRGTRGGANVLVLAPTRE 368
            .:|:||||||||::|||.|:|||||||||||||:||||.||.:.|..||..:.|..:||||||||
Frog   281 ERPTPIQSQAWPVILQGIDLIGIAQTGTGKTLAYLLPGFIHLDLQPIPREQQDGPGMLVLAPTRE 345

  Fly   369 LALQIEMEVKKYSFRGMKAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITY 433
            ||||::.|..||.::|.:::|:||||:||.||:.:.:|.:|:|.||||||||.|.|.:::.:|||
Frog   346 LALQVKAECSKYKYKGFESICIYGGGDRNNQINKVTKGVDIVIATPGRLNDLQMNNFVNLKSITY 410

  Fly   434 LVLDEADRMLDMGFEPQIRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAA 498
            ||||||||||||||||||.|:::||||||.|||||||||.||||||:||:|:|:.|.||:|||||
Frog   411 LVLDEADRMLDMGFEPQIMKILIDIRPDRHTIMTSATWPDGVRRLAKSYLKDPMMVYVGTLDLAA 475

  Fly   499 THSVKQ-IIKLMEDDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGN 562
            .::|.| ::.:.|::...|  :..|:.::...||:|:|.|:|:.||||||:.:|.|...|.:|||
Frog   476 VNTVTQHVLVIPEEEKRAF--VLHFIDSLKPQDKVIVFVGKKLVADDLSSDFSLQGIPVQSLHGN 538

  Fly   563 RDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQG 627
            |:|.|||||:.|.|.|.||||||||:||||||:.|:|||:|:|||.|||||||||||||||||.|
Frog   539 REQCDREQALDDFKKGKVRILVATDLASRGLDVHDVTHVLNFDFPRNIEEYVHRVGRTGRAGRTG 603

  Fly   628 TSISFFTREDWAMAKELIEILQEAEQEVPDELHNMARRFKAMKDKRAAE 676
            .||:..||:||.:|.|||.||:.|.||||.:|.:||.|::..|.|:.:|
Frog   604 ESITLVTRKDWKVAGELISILERANQEVPGDLFDMAERYQQFKIKKDSE 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053	22/66 (33%)
		DEADc	288..489	CDD:238167	126/200 (63%)
		DEXDc	298..505	CDD:214692	134/207 (65%)
		Helicase_C	514..624	CDD:278689	66/109 (61%)
ddx43	NP_001072473.1	KH_1	98..154	CDD:278442	18/55 (33%)
		PRK01297	178..613	CDD:234938	245/455 (54%)
		DEADc	261..466	CDD:238167	128/204 (63%)
		HELICc	479..608	CDD:238034	75/130 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	245	1.000	Domainoid score	I2149
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56814
Inparanoid	1	1.050	575	1.000	Inparanoid score	I1031
OMA	1	1.010	-	-		QHG45820
OrthoDB	1	1.010	-	-		D257031at33208
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		oto103641
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4424
SonicParanoid	1	1.000	-	-		X4523
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110