DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7878 and ddx17

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_001313320.1	Gene:	ddx17 / 556764	ZFINID:	ZDB-GENE-030131-18	Length:	671	Species:	Danio rerio

Alignment Length:	547	Identity:	222/547 - (40%)
Similarity:	321/547 - (58%)	Gaps:	69/547 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 GDRGQDRDNRDHGSNERYDGGGYDRYKGNSYEFNPTSSESNKDNGDLTGIIDWEALNKASIAATA 222
            |||.:|| .||.|          .|: |:|....|...:.. :.||......|:.
Zfish     8 GDRDRDR-GRDRG----------PRF-GSSRAVPPPPKKFG-NPGDRLRKKKWDL---------- 49

  Fly   223 ARWSKCPPLTKNFYKEAPEVANLTKSEIERIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQC 287
               .:.|...||||.|.|||.::::.::|..|.: .:|||          .....|.||..|.|
Zfish    50 ---DQLPKFEKNFYNENPEVHHMSQYDVEEYRRK-REITV----------RGSGCPKPVTNFHQ- 99

  Fly   288 FAEYPD-MLEEITKMGFSKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTP 351
             |::|. :::.:.:..|.:|:.||:|.:|:.|.|.||:||||||:|||||:|||.::|..:|  |
Zfish   100 -AQFPQYVMDVLLQQNFKEPTAIQAQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQ--P 161

  Fly   352 RGTRG-GANVLVLAPTRELALQIEMEVKKY--SFRGMKAVCVYGGGNRNMQISDLERGAEIIICT 413
            ...|| |...||||||||||.|::.....|  |.| :|:.|||||..:..||.|||||.||.|.|
Zfish   162 YLERGDGPICLVLAPTRELAQQVQQVAFDYGKSSR-IKSTCVYGGAPKGPQIRDLERGVEICIAT 225

  Fly   414 PGRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEPQIRKVMLDIRPDRQTIMTSATWPPGVRRL 478
            ||||.|.:.....::...||||||||||||||||||||||::..|||||||:|.|||||..||:|
Zfish   226 PGRLIDFLEVGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQL 290

  Fly   479 AQSYMKNPIQVCVGSLDLAATHSVKQIIKL-MEDDMDKFNTITSFVKNM--SSTDKIIIFCGRKV 540
            |:.::::.:|:.:|:|:|:|.|::.||:.: ||::.|  |.:...::.:  ...:|.|||...|.
Zfish   291 AEDFLQDYVQINIGALELSANHNILQIVDVCMENEKD--NKLIQLMEEIMAEKENKTIIFVETKK 353

  Fly   541 RADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYD 605
            |.|:|:..:..||:...||||::.|.:|:..:.:.:||...||:||||||||||:||:..|||||
Zfish   354 RCDELTRRMRRDGWPAMCIHGDKSQPERDWVLTEFRSGKAPILIATDVASRGLDVEDVKFVINYD 418

  Fly   606 FPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKELIEILQEAEQEVPDELHNMARRFKAMK 670
            :|::.|:||||:|||.|:..:||:.:|||..:...|::|:.:|:||.|.:..:|..:...
Zfish   419 YPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLRQARDLVRVLEEARQAINPKLLQLVDT----- 478

  Fly   671 DKRAAEGGGFGGRGGRFGGGRGGGRRN 697
                       ||||  ||||...|.|
Zfish   479 -----------GRGG--GGGRMRYRGN 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053
		DEADc	288..489	CDD:238167	107/204 (52%)
		DEXDc	298..505	CDD:214692	111/209 (53%)
		Helicase_C	514..624	CDD:278689	49/111 (44%)
ddx17	NP_001313320.1	SrmB	68..574	CDD:223587	198/461 (43%)
		DEADc	97..302	CDD:238167	110/209 (53%)
		HELICc	313..445	CDD:238034	55/133 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910