DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7878 and Rm62

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	726	Identity:	261/726 - (35%)
Similarity:	375/726 - (51%)	Gaps:	145/726 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DDPNYVEK-PAVHQE-------YSKPNNKYERSIRRDGNSRAYKGDRNDYGGEGRGYRAKRNDYG 63
            |..:||:. |...|.       ::.|:.:.| .|:.:|....:  || |:|..|||.|
  Fly   107 DSDDYVDSIPKAEQRTRTRKSLFNDPDERTE-EIKIEGVMAPH--DR-DFGHSGRGGR------- 160

  Fly    64 GGRRDNRDNYGAGHRDSRDSAGGGGGDFSESLSIASEMVGKVIGRGGSNISRIQNDFNVRVKLDK 128
            ||.|...|..|.|...:|...||||||:.                 |....|::
  Fly   161 GGDRGGDDRRGGGGGGNRFGGGGGGGDYH-----------------GIRNGRVE----------- 197

  Fly   129 CDLIVKITGSIQSNVIDAINHVRKQVTNSGDRGQDRDNRDHGSNERYDGGG--YDRYKGNSYEFN 191
                                             :.||  |.|...|:.|||  .||..|
  Fly   198 ---------------------------------KRRD--DRGGGNRFGGGGGFGDRRGG------ 221

  Fly   192 PTSSESNKDNGDLTGIIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIERIREE 256
              ....::|                 :......:|...|..||||:|.|.|||.:..|::|.|||
  Fly   222 --GGGGSQD-----------------LPMRPVDFSNLAPFKKNFYQEHPNVANRSPYEVQRYREE 267

  Fly   257 NNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPD-MLEEITKMGFSKPSPIQSQAWPILLQG 320
             .:|||       .|:    :|||:..|.:  ...|| :::||.:.|:..|:.||:|.|||.:.|
  Fly   268 -QEITV-------RGQ----VPNPIQDFSE--VHLPDYVMKEIRRQGYKAPTAIQAQGWPIAMSG 318

  Fly   321 HDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRGTRGGANVLVLAPTRELALQIEMEVKKY-SFRG 384
            .:.:|||:||:||||.::||.::|...|. |.....|...||||||||||.||:....:: |...
  Fly   319 SNFVGIAKTGSGKTLGYILPAIVHINNQQ-PLQRGDGPIALVLAPTRELAQQIQQVATEFGSSSY 382

  Fly   385 MKAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEP 449
            ::..||:||..:..|:.||:||.||:|.|||||.|.:.|...::...||||||||||||||||||
  Fly   383 VRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDEADRMLDMGFEP 447

  Fly   450 QIRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAATHSVKQIIKLMED--D 512
            ||||::..|||||||:|.|||||..|::||:.::.|.||:.:|||:|:|.|:::|::.:.::  .
  Fly   448 QIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHNIRQVVDVCDEFSK 512

  Fly   513 MDKFNTITSFVKNMS-STDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIK 576
            .:|..|:.|.:.:.| |..|||||...|.|.|:|...:...|.....|||::.|.:|:..:.:.:
  Fly   513 EEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQSERDFVLREFR 577

  Fly   577 SGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMA 641
            ||...||||||||:||||::.|.:|||:|:|.|.|:|:||:|||||:..:|||.:|||:.:...|
  Fly   578 SGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGTSFAFFTKNNAKQA 642

  Fly   642 KELIEILQEAEQEVPDELHNMAR--RFKAMKDKRAAEGGGFGGR--GGRF------------GGG 690
            |.|:::|:||.||:...|.|:||  |:.....:....|||.|||  ||.|            |||
  Fly   643 KALVDVLREANQEINPALENLARNSRYDGGGGRSRYGGGGGGGRFGGGGFKKGSLSNGRGFGGGG 707

  Fly   691 RGGGRRNFDQF 701
            .|||.....:|
  Fly   708 GGGGEGRHSRF 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053	2/57 (4%)
		DEADc	288..489	CDD:238167	100/202 (50%)
		DEXDc	298..505	CDD:214692	104/207 (50%)
		Helicase_C	514..624	CDD:278689	50/110 (45%)
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	172/378 (46%)
		DEADc	283..488	CDD:238167	102/207 (49%)
		HELICc	499..633	CDD:238034	54/133 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451494
Domainoid	1	1.000	152	1.000	Domainoid score	I185
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		mtm9750
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890