DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7878 and Ddx1

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_524212.2	Gene:	Ddx1 / 40457	FlyBaseID:	FBgn0015075	Length:	727	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	131/563 - (23%)
Similarity:	227/563 - (40%)	Gaps:	139/563 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 VTNSGDRGQDRDNRD----------HGSNERY------DGG----GYDRYKGN--------SYEF 190
            ||..|.|.|.|:.::          .|..:.|      |.|    |:...:.|        .:.|
  Fly   102 VTPDGLRCQSREFKEWHGCRATTGVRGKGKFYFEATVTDEGLCRVGWSTQQANLDLGTCRMGFGF 166

  Fly   191 NPTSSESNKDNGDLTGIIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIERIRE 255
            ..|..:||....|..|    ||..||.:..       |             :.:|...|:...:.
  Fly   167 GGTGKKSNNRQFDDYG----EAFGKADVIG-------C-------------LLDLKNQEVSFTKN 207

  Fly   256 ENNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPDMLEEITKMGFS------KPSPIQSQAW 314
            ..| :.|::           .:|:.:  .::.|  ||.::.:..:|.|:      |.:|
  Fly   208 GQN-LGVAF-----------RLPDNL--AKETF--YPAVVLKNAEMQFNFGKTDFKYAP------ 250

  Fly   315 PILLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRGTRGGANVLVLAPTRELALQIEMEVKK 379
                 |:..:|..|.|...:.|..:.|.......:.|  .......:::.|:||||.|...:::|
  Fly   251 -----GNGFVGACQAGPEHSKANPITGPAAGAPSAKP--APNAPQAIIMEPSRELAEQTYNQIEK 308

  Fly   380 YSFR----GMKAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLVLDEAD 440
            :.:.    .::::.:.||.....|.:.|.:|..|::.|||||.::|.:.::.::...:.||||||
  Fly   309 FKYHLSNPEVRSLLLIGGVRLEEQKAQLMQGTHIVVGTPGRLEEMINSGLVLLTHCRFFVLDEAD 373

  Fly   441 RMLDMGF-------EPQIRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAA 498
            .:|..|:       ..||.|:..|.|..:..:.::......|:::|:..|..|..|.:...| |.
  Fly   374 ALLKQGYTELIDRLHKQIPKITSDGRRLQMVVCSATLHAFEVKKMAERLMHFPTWVDLKGED-AV 437

  Fly   499 THSVKQIIKLMEDDMD--------------------------KFNTITSFVK-----------NM 526
            ..:|..::.|::..||                          ...|::..||           :.
  Fly   438 PETVHHVVCLVDPQMDTTWQSLRQPIGTDGVHDRDNVHPGNHSKETLSQAVKLLKGEYCVHAIDK 502

  Fly   527 SSTDKIIIFCGRKVRADDLSSELTLDG---FMTQCIHGNRDQMDREQAIADIKSGVVRILVATDV 588
            .:.|:.||||..|...|:|...|...|   :...|:||:|...:|::.:...|...|:.|:.|||
  Fly   503 HNMDRAIIFCRTKQDCDNLERFLRQRGGKHYSCVCLHGDRKPQERKENLEMFKRQQVKFLICTDV 567

  Fly   589 ASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSIS 631
            |:|||||..:..:||...|.:...||||:||.|||.|.|.:||
  Fly   568 AARGLDITGLPFMINVTLPDDKTNYVHRIGRVGRAERMGLAIS 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053
		DEADc	288..489	CDD:238167	50/217 (23%)
		DEXDc	298..505	CDD:214692	51/223 (23%)
		Helicase_C	514..624	CDD:278689	42/149 (28%)
Ddx1	NP_524212.2	P-loop_NTPase	4..>62	CDD:304359
		SPRY_DDX1	91..242	CDD:293933	33/179 (18%)
		SrmB	279..>612	CDD:223587	90/335 (27%)
		P-loop_NTPase	<280..426	CDD:304359	36/147 (24%)
		Helicase_C	492..602	CDD:278689	37/109 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840