DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7878 and CG6418

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_648413.1	Gene:	CG6418 / 39218	FlyBaseID:	FBgn0036104	Length:	791	Species:	Drosophila melanogaster

Alignment Length:	716	Identity:	228/716 - (31%)
Similarity:	340/716 - (47%)	Gaps:	125/716 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NSRAYKGDRNDYGGEGRG----------------------YRAKRNDYGGGRRDNRDNYGAGHRD 79
            |:|.|.|.|..:||..||                      |....|..|..:....|:|.....:
  Fly    34 NARGYSGSRGGFGGASRGGVTGSTTSTSKHGYSTLDSISQYTNATNLVGKRKHHTDDDYFDDDDE 98

  Fly    80 SRDS--------AGGGGGDFSESLSIASEMVGKVIGRGGSN---ISRIQNDFNVRVKLDKCDLIV 133
            .|:.        |.|..|        |.....|......|:   :.:.....|.:|:.:|.....
  Fly    99 PREKEIEQAYIPAPGSPG--------APPTSAKKQEDSDSDEDPLEQFMAGINQQVEKEKRQQAP 155

  Fly   134 K-ITGSIQSNVID-----AINHVRKQVTNSGDRGQDRDNRDHGSNE--RYDGGGYDRYKGNSYEF 190
            | .|.:::.::.|     :.....|:..|:|       .||.||::  .||..|
  Fly   156 KPPTQAVRGDIDDEDDEESYYRYMKENPNAG-------LRDEGSDQEIEYDEDG----------- 202

  Fly   191 NPTSSESNKDNGDLTGI----IDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIE 251
            ||.:....||...|..|    |::|                  |..||||.:..::|.|   :.|
  Fly   203 NPIAPPKKKDIDPLPPIYHSEIEYE------------------PFEKNFYTQHDDIAAL---DDE 246

  Fly   252 RIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPDMLEEITKMGFSKPSPIQSQAWPI 316
            ::||....:.|..        |.|..|.||.:|.. |.....:::.:.|..:::|:|||:||.|.
  Fly   247 QVRELRRTLGVKV--------TGPSPPKPVTSFGH-FGFDEQLIKAVRKAEYTQPTPIQAQAVPT 302

  Fly   317 LLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRGTRGGANVLVLAPTRELALQIEMEVKKY- 380
            .|.|.|:||||:||:|||.||:.|.::|...|...:...|... |:|||||||:|||..|.||:
  Fly   303 ALSGRDIIGIAKTGSGKTAAFIWPMLMHVMDQKQLKPGDGPIG-LILAPTRELSLQIYNEAKKFG 366

  Fly   381 SFRGMKAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLVLDEADRMLDM 445
            ....:..||.||||::..|...||:|||||:.||||:.|::.....::..:|:|||||||||..|
  Fly   367 KVYNLNVVCCYGGGSKWEQSKALEQGAEIIVATPGRMIDMVKMKATNLRRVTFLVLDEADRMFHM 431

  Fly   446 GFEPQIRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAATHSVKQIIKLME 510
            |||||:|.:...:|||||.:|.|||:...:.|||:..:.:|:::..|.|: .|...:.|.:.:..
  Fly   432 GFEPQVRSICNHVRPDRQCLMFSATFKKRIERLARDVLSDPVRIVQGDLN-EANQDITQSVYVFP 495

  Fly   511 DDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIADI 575
            :.:.|:|.:...:....|...::||..:||.|:.:|:.|.:..:....:||:.||.||.:.|...
  Fly   496 NPLQKWNWLLCHLVKFLSEGSVLIFVTKKVDAETVSNNLLIKEYNCLLLHGDMDQADRNKVITQF 560

  Fly   576 KSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAM 640
            |.....||||||||:|||||..|.:|:|||...:||.:.||:|||||||.:|.:.:..|.:|...
  Fly   561 KRKECDILVATDVAARGLDIPHIRNVVNYDTARDIETHTHRIGRTGRAGEKGNAYTLVTDKDKEF 625

  Fly   641 AKELIEILQEAEQEVPDELHNMA--------RRFKAMKDKRAAE-------------GGGFGGRG 684
            |..|:..|:.|:|.|||:|..:|        .|||..|.||...             |||:|..|
  Fly   626 AGHLVRNLEGADQLVPDDLMELAMKSSWFRSSRFKQGKGKRPTNTHTGLGYREKGNGGGGYGSAG 690

  Fly   685 G 685
            |
  Fly   691 G 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053	9/66 (14%)
		DEADc	288..489	CDD:238167	90/201 (45%)
		DEXDc	298..505	CDD:214692	92/207 (44%)
		Helicase_C	514..624	CDD:278689	45/109 (41%)
CG6418	NP_648413.1	DEADc	271..475	CDD:238167	91/205 (44%)
		DEXDc	284..489	CDD:214692	92/206 (45%)
		Helicase_C	504..609	CDD:278689	43/104 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451491
Domainoid	1	1.000	152	1.000	Domainoid score	I185
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9750
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840