DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7878 and CG10333

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	238/820 - (29%)
Similarity:	364/820 - (44%)	Gaps:	209/820 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EKPAVHQEYSKPNNKYERSIRRDGNSRAYKGDRN-DYGGEGRGYRAKRNDYGGGRRD-----NRD 71
            ::|||       .|..:|...||   |..:.||. |...|.|..|::..:....||.     .||
  Fly    18 DRPAV-------GNPRDRERERD---RVRERDRQFDREKERRQRRSRSREDRNRRRSPERQRPRD 72

  Fly    72 NYGAGHRDSRDSAGGGGGDFSESLSIASE--------MVGKVIGRGGSNISRIQNDFNVRVKLDK 128
            |.....|:....||||||..:|..:....        :|.....:.|......:...::...|||
  Fly    73 NVRERSRERGGGAGGGGGGGAEKKAKMDTGDAPPKPLIVDDEEQQDGKEAKVKKEPLSLEELLDK 137

  Fly   129 CD----------LIVKITGSIQSNVIDAINHVRKQVTN--------------------------- 156
            ..          .:.|     :...::||...:::|..
  Fly   138 KKREEEARSKPVFLTK-----EQRALEAIKRRQEEVERQRAAHDAAREQMAAASKVSISMGTAMA 197

  Fly   157 SG-------------DRGQDRDNRDHGSN-ERYDGGGYDRYKGNSYEFNPTSSESNKDN------ 201
            ||             ||.:....||.|.. :|.:.|...|.:..:::......|:.::.
  Fly   198 SGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKRAEDLTHKDKEKELEAIRERYLGIIK 262

  Fly   202 --------GDLTGIIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEV-----ANL-------- 245
                    .|...:.||:|....||.            ..|.|||...|     .|:
  Fly   263 KKRRVRRLNDRKFVFDWDAGEDTSID------------YNNLYKERHHVQFFGRGNVAGIDIKEQ 315

  Fly   246 ------------------TKSEIERIR--------------------EENNKIT--------VSY 264
                              .:.|.|::|                    :||:::|        ..|
  Fly   316 KRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDEMTERDWRIFREDY 380

  Fly   265 VFEPKEGETSPPIPNPVWTFEQCFAEYP-DMLEEITKMGFSKPSPIQSQAWPILLQGHDMIGIAQ 328
            ....|.|.    ||||:.::.:  :.:| ::::.|.|:|:.:|:|||.||.||.||..|:||:|:
  Fly   381 NVTIKGGR----IPNPIRSWNE--SGFPKEIIDIIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAE 439

  Fly   329 TGTGKTLAFLLPGMIHTEYQSTPRGTR-----GGANVLVLAPTRELALQIEMEVKKYSF-RGMKA 387
            ||:|||||||:|  :.:..||.|:..|     .|...:::|||||||.|||.|..|:.. .|::.
  Fly   440 TGSGKTLAFLIP--LLSWIQSLPKIERLEDVDQGPYAIIMAPTRELAQQIEEETTKFGQPLGIRT 502

  Fly   388 VCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEPQIR 452
            |.|.||.:|..|...|..|.||:|.|||||.|::....:.::..||:||||||||:||||||.::
  Fly   503 VVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGFEPDVQ 567

  Fly   453 KVM-----LDIRPD--------------------RQTIMTSATWPPGVRRLAQSYMKNPIQVCVG 492
            |::     .:::||                    |||:|.:||.||.|.|||::|::.|..|.:|
  Fly   568 KILEYMPVTNLKPDTEEAEDETKLMENFYTKKKYRQTVMFTATMPPAVERLARTYLRRPATVYIG 632

  Fly   493 SLDLAATHSVKQIIKLMEDDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQ 557
            |:. ..|...:||:.:|.:: ||...:.. :.:......:|||..:|..||.|:..|...|:.:.
  Fly   633 SVG-KPTERTEQIVYMMGEN-DKRKKLME-ILSRKIDPPVIIFVNQKKGADVLAKGLEKLGYNSC 694

  Fly   558 CIHGNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGR 622
            .:||.:.|..||.|:|.:|||...||||||||.||:||:|::.|||||....||:|.||:|||||
  Fly   695 TLHGGKGQEQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGR 759

  Fly   623 AGRQGTSISFFTREDWAMAKELIEILQEAE-QEVPDELHN 661
            ||:.|.:|||.|::|.|:..:|.:.:..:. ...|.||.|
  Fly   760 AGKTGCAISFVTKDDSALFYDLKQCVSASPVSTCPPELMN 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053	9/75 (12%)
		DEADc	288..489	CDD:238167	96/232 (41%)
		DEXDc	298..505	CDD:214692	99/237 (42%)
		Helicase_C	514..624	CDD:278689	49/109 (45%)
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	96/236 (41%)
		DEXDc	409..632	CDD:214692	96/224 (43%)
		Helicase_C	651..761	CDD:278689	49/111 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9750
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940