DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7878 and Ddx5

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_001007614.1	Gene:	Ddx5 / 287765	RGDID:	619906	Length:	615	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	216/560 - (38%)
Similarity:	325/560 - (58%)	Gaps:	70/560 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 DRGQDRDNRDHGSNERYDGGGYDRYKGNSYEFNPTSSESNKDNGDLTGIIDWEALNKASIAATAA 223
            |||:||            |.|..|:                 .|..||.:..:............
  Rat     9 DRGRDR------------GFGAPRF-----------------GGSRTGPLSGKKFGNPGEKLVKK 44

  Fly   224 RWS--KCPPLTKNFYKEAPEVANLTKSEIERIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQ 286
            :|:  :.|...||||:|.|::|..|..|::..| .:.:|||       .|..   .|.||..|.:
  Rat    45 KWNLDELPKFEKNFYQEHPDLARRTAQEVDTYR-RSKEITV-------RGHN---CPKPVLNFYE 98

  Fly   287 CFAEYP-DMLEEITKMGFSKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQST 350
              |.:| ::::.|.:..|::|:.||:|.||:.|.|.||:|:||||:||||::|||.::|..:|
  Rat    99 --ANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQ-- 159

  Fly   351 PRGTRG-GANVLVLAPTRELALQIEMEVKKY--SFRGMKAVCVYGGGNRNMQISDLERGAEIIIC 412
            |...|| |...||||||||||.|::....:|  :.| :|:.|:|||..:..||.|||||.||.|.
  Rat   160 PFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACR-LKSTCIYGGAPKGPQIRDLERGVEICIA 223

  Fly   413 TPGRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEPQIRKVMLDIRPDRQTIMTSATWPPGVRR 477
            |||||.|.:.....::...||||||||||||||||||||||::..|||||||:|.|||||..||:
  Rat   224 TPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQ 288

  Fly   478 LAQSYMKNPIQVCVGSLDLAATHSVKQIIKLMEDDMDKFNTITSFVKNMSS--TDKIIIFCGRKV 540
            ||:.::|:.|.:.:|:|:|:|.|::.||:.:.. |::|...:...::.:.|  .:|.|:|...|.
  Rat   289 LAEDFLKDYIHINIGALELSANHNILQIVDVCH-DVEKDEKLIRLMEEIMSEKENKTIVFVETKR 352

  Fly   541 RADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYD 605
            |.|:|:.::..||:....|||::.|.:|:..:.:.|.|...||:||||||||||:||:..|||||
  Rat   353 RCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYD 417

  Fly   606 FPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKELIEILQEAEQEVPDELHNMARRFKAMK 670
            :|::.|:|:||:|||.|:.:.||:.:|||..:.....:||.:|:||.|.:..:|      .:.::
  Rat   418 YPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKL------LQLVE 476

  Fly   671 DKRAAEGGGFGG----RGGRFGGGRGGG------RRNFDQ 700
            |:.:....|.||    |..|:..|:.||      |.|:|:
  Rat   477 DRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053
		DEADc	288..489	CDD:238167	107/204 (52%)
		DEXDc	298..505	CDD:214692	110/209 (53%)
		Helicase_C	514..624	CDD:278689	46/111 (41%)
Ddx5	NP_001007614.1	PTZ00110	6..507	CDD:240273	213/549 (39%)
Ddx5	NP_001007614.1	P68HR	498..532	CDD:400414	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910