Protein Alignment CG7878 and Ddx46

DIOPT Version :10

• Sequence 1: NP_649767.1
• Gene: CG7878 / 40959
• FlyBaseID: FBgn0037549
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_620798.1
• Gene: Ddx46 / 245957
• RGDID: 708480
• Length: 1032
• Species: Rattus norvegicus
• Alignment Length: 765
• Identity: 244/765 - (31%)
• Similarity: 371/765 - (48%)
• Gaps: 132/765 - (17%)

  Fly    25 NNKYERSIRRD---GNSRAYKGDRNDYGGEGRGYRAKRNDYGGGRRDNRDNYGAGHRDSRDSAGG 86
            :.:.|||..||   ..||..|..|.....|....|.:|......||.:|.. ..|.| ||.|:.|
  Rat    46 DRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSR-SRGRR-SRSSSPG 108

  Fly    87 GGGDFSESLSIASEMVGKVIGRGGSNISRIQNDFNVRVKLDKCDLIVKITGSIQSNVIDAINHVR 151
            .....:|:.|.:.|.     ..||.:....:.|     |.||.|...|..|:...|.::.....|
  Rat   109 SKSKKAENRSRSKEK-----AEGGDSSKEKKKD-----KDDKEDEKEKDAGNFDQNKLEEEMRKR 163

  Fly   152 KQ-------------VTNSGD---------RGQ------DRDNRDHGSNERYDGG--------GY 180
            |:             :.|.|:         :|:      |.|:.|..:....:|.        ..
  Rat   164 KERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEDEELDPL 228

  Fly   181 DRY-------------------KGNSYEFNPTSS-------------ESNKDNGDL--------- 204
            |.|                   .||..:..||.:             :::|..|:|
  Rat   229 DAYMEEVKEEVKKFNMRSVKGGAGNEKKSGPTVTKVVTVVTTKKAVVDADKKKGELMENDQDAME 293

  Fly   205 -----------TGIIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIERIREENN 258
                       |.:..::...:..:........:..|..||||.|.||:|.:::.|:...|.|..
  Rat   294 YSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEME 358

  Fly   259 KITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPDMLEEITKMGFSKPSPIQSQAWPILLQGHDM 323
            .|||.          ....|.|:.::.||.... .:|..:.|.|:.||:|||:||.|.::.|.|:
  Rat   359 GITVK----------GKGCPKPIKSWVQCGISM-KILNSLKKHGYEKPTPIQTQAIPAIMSGRDL 412

  Fly   324 IGIAQTGTGKTLAFLLPGMIH-TEYQSTPRGTRGGANVLVLAPTRELALQIEMEVKKYS-FRGMK 386
            ||||:||:|||:|||||...| .:.:|...|.  |...:::.|||||||||..|.||:| ..|::
  Rat   413 IGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGE--GPIAVIMTPTRELALQITKECKKFSKTLGLR 475

  Fly   387 AVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMAN---VIDVSTITYLVLDEADRMLDMGFE 448
            .||||||...:.||::|:||||||:|||||:.|::.||   |.::..:||:||||||||.|||||
  Rat   476 VVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFE 540

  Fly   449 PQIRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAATHSVKQIIKLMEDDM 513
            ||:.:::.::||||||:|.|||:|..:..||:..:..||:|.||...:..:...:|:|.:.|:
  Rat   541 PQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEE-- 603

  Fly   514 DKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSG 578
            .||..:...:.:...:..:|||..::..||.|..:|....:....:||..||.||:..|.|.|:|
  Rat   604 KKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNG 668

  Fly   579 VVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKE 643
            ..::||||.||:||||::.:..|:||..|::.|:||||.|||||||.:|.:.:|.|.:....|.:
  Rat   669 TCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGD 733

  Fly   644 LIEILQEAEQEVPDELHNMARRFKAMKDKRAAEG------GGFGGRGGRF 687
            :|:.|:.:...||.:|..:...|   ||::.|||      .||.|:|.:|
  Rat   734 IIKALELSGTAVPPDLEKLWSDF---KDQQKAEGKIIKKSSGFSGKGFKF 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH_1	92..152	CDD:459630	13/59 (22%)
		DEAD-like_helicase_N	174..663	CDD:475120	191/553 (35%)
Ddx46	NP_620798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..227		43/192 (22%)
		DEADc_DDX46	361..582	CDD:350711	107/233 (46%)
		Q motif	372..400		9/28 (32%)
		SrmB	378..793	CDD:440279	172/411 (42%)
		DEAD box	529..532		2/2 (100%)
		KH-I_DDX46	929..1031	CDD:411901