Protein Alignment CG7878 and laf-1

DIOPT Version :10

• Sequence 1: NP_649767.1
• Gene: CG7878 / 40959
• FlyBaseID: FBgn0037549
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_001254859.1
• Gene: laf-1 / 190611
• WormBaseID: WBGene00002244
• Length: 708
• Species: Caenorhabditis elegans
• Alignment Length: 720
• Identity: 231/720 - (32%)
• Similarity: 338/720 - (46%)
• Gaps: 159/720 - (22%)

  Fly    35 DGNSRAYK---GDRNDYGGEGRGYRAKRNDYGGG-----------RRDNRDNYGAGHRDSRD--- 82
            ||.:.|..   ||....|..|.|||....:.|||           .||:|||.|......||
 Worm    31 DGGAAAAASAGGDDRRGGAGGGGYRRGGGNSGGGGGGGYDRGYNDNRDDRDNRGGSGGYGRDRNY 95

  Fly    83 -----SAGGGGGDFSESLSIASEMVGKVIGRGGSNISRIQNDFNVRVKLDKCDLIVKITGSIQSN 142
                 :.|||||                 |..|.|.:|
 Worm    96 EDRGYNGGGGGG-----------------GNRGYNNNR--------------------------- 116

  Fly   143 VIDAINHVRKQVTNSGDRGQDRDNRDHGSNERYDGGGY--------DRYKGNSYEFNPTSSESNK 199
                         ..|..|.:|.:|..|.:..:..|||        :|..|.||      :...:
 Worm   117 -------------GGGGGGYNRQDRGDGGSSNFSRGGYNNRDEGSDNRGSGRSY------NNDRR 162

  Fly   200 DNGDLTGIIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSE-----IERIREENNK 259
            |||.       :..|        .||:..         :||.....:|.|     .|||.:|...
 Worm   163 DNGG-------DGQN--------TRWNNL---------DAPPSRGTSKWENRGARDERIEQELFS 203

  Fly   260 ITVSYVFEPKEGE-----TSPPIPNPVWTFEQCFAEYPDMLEE-ITKMGFSKPSPIQSQAWPILL 318
            ..:|.:...|..|     |...:|.|:..|..  ....:.:|| |...|:.:|:|:|..:.|.|.
 Worm   204 GQLSGINFDKYEEIPVEATGDDVPQPISLFSD--LSLHEWIEENIKTAGYDRPTPVQKYSIPALQ 266

  Fly   319 QGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRG------TRGG-----ANVLVLAPTRELALQ 372
            .|.|::..||||:|||.|||:| :::...|..|..      :.||     .:.|||:|||||:||
 Worm   267 GGRDLMSCAQTGSGKTAAFLVP-LVNAILQDGPDAVHRSVTSSGGRKKQYPSALVLSPTRELSLQ 330

  Fly   373 IEMEVKKYSFR-GMKAVCVYGG-GNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLV 435
            |..|.:|:::| .:.:..:||| .|...||..|..|..|:|.|||||.|::...:|.:....|||
 Worm   331 IFNESRKFAYRTPITSALLYGGRENYKDQIHKLRLGCHILIATPGRLIDVMDQGLIGMEGCRYLV 395

  Fly   436 LDEADRMLDMGFEPQIRKVM----LDIRPDRQTIMTSATWPPGVRRLAQSYMK-NPIQVCVGSLD 495
            |||||||||||||||||:::    :..:.:|.|.|.|||:|..::.|||.::| |.:.:.||.:.
 Worm   396 LDEADRMLDMGFEPQIRQIVECNRMPSKEERITAMFSATFPKEIQLLAQDFLKENYVFLAVGRVG 460

  Fly   496 LAATHSVKQIIKLMEDDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIH 560
            ..:.:.:::|:.:.||  :|.:.:...:.....:...::|...|..|.||:..|....:....||
 Worm   461 STSENIMQKIVWVEED--EKRSYLMDLLDATGDSSLTLVFVETKRGASDLAYYLNRQNYEVVTIH 523

  Fly   561 GNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGR 625
            |:..|.:||:.:...::|...|||||.||:|||||.::.||||||.|.:::|||||:|||||.|.
 Worm   524 GDLKQFEREKHLDLFRTGTAPILVATAVAARGLDIPNVKHVINYDLPSDVDEYVHRIGRTGRVGN 588

  Fly   626 QGTSISFFTREDWAMAKELIEILQEAEQEVPDELHNMARRFKAMKDKRAAEGGGFGGRGGRFGGG 690
            .|.:.|||..::..:|:||::::.||.||:||.|..|:      .|.|:  |||:.|||||..|.
 Worm   589 VGLATSFFNDKNRNIARELMDLIVEANQELPDWLEGMS------GDMRS--GGGYRGRGGRGNGQ 645

  Fly   691 RGGGR 695
            |.|||
 Worm   646 RFGGR 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH_1	92..152	CDD:459630	4/59 (7%)
		DEAD-like_helicase_N	174..663	CDD:475120	180/525 (34%)
laf-1	NP_001254859.1	SrmB	233..619	CDD:440279	150/390 (38%)