Protein Alignment CG7878 and glh-2

DIOPT Version :10

• Sequence 1: NP_649767.1
• Gene: CG7878 / 40959
• FlyBaseID: FBgn0037549
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_491876.1
• Gene: glh-2 / 172361
• WormBaseID: WBGene00001599
• Length: 974
• Species: Caenorhabditis elegans
• Alignment Length: 739
• Identity: 214/739 - (28%)
• Similarity: 331/739 - (44%)
• Gaps: 108/739 - (14%)

  Fly     5 DWDDPNYVEKPAVHQEYSKPNNK-----YERSIRRDGNSRAYKGDRNDYGGEGRGYRAKRNDYGG 64
            |..:|....:|.|.....:|.:.     .||..|...|  .:.|..:.:|| |.|        ||
 Worm   271 DCPEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRN--GFTGGSSGFGG-GNG--------GG 324

  Fly    65 GRRDNRDNYGAGHRDSRDSAGGGGGDFSESLSIASEMVGKVIGRGGSNI-SRIQNDFNVRVKLDK 128
            ...|:....|.|..::.:|..|.||....|....|       |.||.:. .|..|.||.:.
 Worm   325 TGFDSGLTNGFGSGNNGESGFGSGGFGGNSNGFGS-------GGGGQDRGERNNNCFNCQQ---- 378

  Fly   129 CDLIVKITGSIQSNVIDAINHVRKQVT--------NSGDRGQDRDNRD---------HGSNERYD 176
                   .|...::..:.......:|.        ||.|..::|..|:         .|.|:...
 Worm   379 -------PGHRSNDCPEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRNGFTSGFGGGNDGGF 436

  Fly   177 GGGYDRYKGNSYEFNPTSSESNKDNGDLTGIIDWEALNKASIAATAARWSKCPPLTK---NFYKE 238
            |||.....||:.|..|....:.|..|..:...........:......|.::||...|   ....|
 Worm   437 GGGNAEGFGNNEERGPMKCFNCKGEGHRSAECPEPPRGCFNCGEQGHRSNECPNPAKPREGAEGE 501

  Fly   239 APEVANL----TKSEIERIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEY---PDMLE 296
            .|:...:    ...|:..:::.:..:..:..|:.:...||...|..|.|. :.|:|.   ..|.:
 Worm   502 GPKATYVPVEDNMEEVFNMQKISEGLMFNKFFDAEVKITSDKKPVGVKTC-KTFSEANLGETMKK 565

  Fly   297 EITKMGFSKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGM--IHTEYQSTPRGTRGGA- 358
            .:...|::|.:|||....|::.||||::..||||:|||.|||||.|  :..|......| .||.
 Worm   566 NVAHAGYTKTTPIQQYTLPLIHQGHDIMACAQTGSGKTAAFLLPIMARLIDENDLNTAG-EGGCY 629

  Fly   359 -NVLVLAPTRELALQIEMEVKKYSFRGMKAV-CVYGGGNRNMQISDLERGAEIIICTPGRLNDLI 421
             ..::|.|||||..||..|.:|::::.|..: .||||.........:|:||.||:.|.||:....
 Worm   630 PRCIILTPTRELTDQIYNEGRKFAYQTMMEIRPVYGGLAVGYNKGQIEKGATIIVGTVGRIKHFC 694

  Fly   422 MANVIDVSTITYLVLDEADRMLD-MGFEPQIRKVM----LDIRPDRQTIMTSATWPPGVRRLAQS 481
            ....|.:....:.||||||||:| |||...|..::    :..:.:|||:|.|||:|..|:..|::
 Worm   695 EEGTIKLDKCRFFVLDEADRMIDAMGFGTDIDTIVNYESMPKKENRQTLMFSATFPDSVQEAARN 759

  Fly   482 YMKNP-IQVCVGSLDLAATHSVKQ-------------IIKLMEDDMDKFNTITSFVKNMS-STDK 531
            ::|.. |.:.:..:. ||...|.|             :::::..|:|.:.|    .||.. .|.|
 Worm   760 HLKEGYIMLAIDKIG-AANKCVLQEFEKCDRSEKKDKLLEILGIDIDSYTT----EKNSEVYTKK 819

  Fly   532 IIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSGVVRILVATDVASRGLDIE 596
            .|:|..::..||.|:|.|:........|||.|:|.:|.:|:...::|...:|:||.||.|||||:
 Worm   820 TIVFVSQRAMADTLASILSSAQVPAITIHGAREQRERSEALRQFRNGSKPVLIATAVAERGLDIK 884

  Fly   597 DITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKELIEILQEAEQEVPDELHN 661
            .:.||||||.|.||::|:||:|||||.|..|.:.||.: ||..:..||:.:|.:|:|.||:.:
 Worm   885 GVDHVINYDMPDNIDDYIHRIGRTGRVGNAGRATSFIS-EDCNLLSELVRVLSDADQLVPEWM-- 946

  Fly   662 MARRFKAMKDKRAAEGGGFGGRGG 685
                       :.|.||.||...|
 Worm   947 -----------QGASGGNFGASFG 959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH_1	92..152	CDD:459630	10/60 (17%)
		DEAD-like_helicase_N	174..663	CDD:475120	167/523 (32%)
glh-2	NP_491876.1	Keratin_2_head	73..>177	CDD:465068
		PTZ00368	<250..300	CDD:173561	5/28 (18%)
		PTZ00368	373..508	CDD:173561	26/145 (18%)
		SrmB	553..924	CDD:440279	136/377 (36%)