Protein Alignment CG7878 and DDX53

DIOPT Version :10

• Sequence 1: NP_649767.1
• Gene: CG7878 / 40959
• FlyBaseID: FBgn0037549
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_874358.2
• Gene: DDX53 / 168400
• HGNCID: 20083
• Length: 631
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 269/616 - (43%)
• Similarity: 375/616 - (60%)
• Gaps: 42/616 - (6%)

  Fly    79 DSRDSAGGG-GGDFSES-------------LSIASEMVGKVIGRGGSNISRIQNDFNVRVKLDKC 129
            |.|.|.|.| .|.|...             ..|.:.|||.|||..||.|..:|:..|.::::
Human    23 DVRGSRGSGWSGPFGHQGPRAAGSREPPLCFKIKNNMVGVVIGYSGSKIKDLQHSTNTKIQI--- 84

  Fly   130 DLIVKITGSIQSNVIDAINHVRKQVTNSGDRGQDRDNRDHGSNERYDGGGYDRYKGNSYEFNPTS 194
                 |.|..::.|....|...|....:......|....:.|....|...           :.|.
Human    85 -----INGESEAKVRIFGNREMKAKAKAAIETLIRKQESYNSESSVDNAA-----------SQTP 133

  Fly   195 SESNKDNGDLTG----IIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIERIRE 255
            ...|....|:.|    :.:|:.:..|.:.....:|:..||:.||||.|:...:.:::.::...|:
Human   134 IGRNLGRNDIVGEAEPLSNWDRIRAAVVECEKRKWADLPPVKKNFYIESKATSCMSEMQVINWRK 198

  Fly   256 ENNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPDMLEEITKMGFSKPSPIQSQAWPILLQG 320
            ||..||..   :.|.|| ...||.|...|:..|.:|||:|:.|.::|..||:|||||||||:|||
Human   199 ENFNITCD---DLKSGE-KRLIPKPTCRFKDAFQQYPDLLKSIIRVGIVKPTPIQSQAWPIILQG 259

  Fly   321 HDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRGTRGGANVLVLAPTRELALQIEMEVKKYSFRGM 385
            .|:|.:|||||||||::|:||.||.:.|...|..|.|..:|||.|||||||.:|.|..|||::|:
Human   260 IDLIVVAQTGTGKTLSYLMPGFIHLDSQPISREQRNGPGMLVLTPTRELALHVEAECSKYSYKGL 324

  Fly   386 KAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEPQ 450
            |::|:|||.|||.||.|:.:|.:|||.||||||||.|.|.:::.:|||||:||||:||||.||||
Human   325 KSICIYGGRNRNGQIEDISKGVDIIIATPGRLNDLQMNNSVNLRSITYLVIDEADKMLDMEFEPQ 389

  Fly   451 IRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAATHSVKQIIKLMEDDMDK 515
            |||::||:||||||:|||||||..||:||.||:|:|:.|.||:|:|.|.::|||.| ::..:.:|
Human   390 IRKILLDVRPDRQTVMTSATWPDTVRQLALSYLKDPMIVYVGNLNLVAVNTVKQNI-IVTTEKEK 453

  Fly   516 FNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSGVV 580
            ......||:|||..||:|:|..:|..||||||:..:.|...:.:|||.:|.|:|:|:.|.|||.:
Human   454 RALTQEFVENMSPNDKVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVEDFKSGNI 518

  Fly   581 RILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKELI 645
            :||:.||:.|||||:.|:|||.|||||.||:.||||||..||.|:.|||::..|:.|..||.|||
Human   519 KILITTDIVSRGLDLNDVTHVYNYDFPRNIDVYVHRVGYIGRTGKTGTSVTLITQRDSKMAGELI 583

  Fly   646 EILQEAEQEVPDELHNMARRFKAMKDKRAAE 676
            :||..|.|.||::|..||.::|..:.||..|
Human   584 KILDRANQSVPEDLVVMAEQYKLNQQKRHRE 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH_1	92..152	CDD:459630	16/72 (22%)
		DEAD-like_helicase_N	174..663	CDD:475120	237/492 (48%)
DDX53	NP_874358.2	KH-I_DDX43_DDX53	50..115	CDD:411858	17/72 (24%)
		Q motif	222..250		12/27 (44%)
		SrmB	231..625	CDD:440279	214/385 (56%)
		DEAD box	376..379		2/2 (100%)