Protein Alignment CG7878 and Ddx4

DIOPT Version :10

• Sequence 1: NP_649767.1
• Gene: CG7878 / 40959
• FlyBaseID: FBgn0037549
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: XP_011242920.1
• Gene: Ddx4 / 13206
• MGIID: 102670
• Length: 738
• Species: Mus musculus
• Alignment Length: 754
• Identity: 219/754 - (29%)
• Similarity: 338/754 - (44%)
• Gaps: 161/754 - (21%)

  Fly     1 MSDLDWDDPNYVEKPAVHQEYSKPN-NKYERSIRRDGNSRAYKGD--------------RNDYGG 50
            |.|.||:           .|..||: :.|.....:|..|....||              ..:.|.
Mouse     1 MGDEDWE-----------AEILKPHVSSYVPVFEKDKYSSGANGDTFNRTSASSVLFALEMEDGP 54

  Fly    51 EGRGYRAKRNDYGGGRRDNRDNYGAGHRDSRDSAGGGGGDFSESLSIASEMVGKVIGRGGSNISR 115
            .||. ...|:.:..||.....:.|...:....|..||.|.                |:|..|...
Mouse    55 SGRD-DFMRSGFPSGRSLGSRDIGESSKKENTSTTGGFGR----------------GKGFGNRGF 102

  Fly   116 IQNDFNVRVKLDKCDLIVKITGSIQSNVIDAINHVRKQVTNS---GDRGQDRDNRDHGSNERYDG 177
            :.|.|.              .|.......::.|......|.|   ..||..:|..|..::..:..
Mouse   103 LNNKFE--------------EGDSSGFWKESNNDCEDNQTRSRGFSKRGGCQDGNDSEASGPFRR 153

  Fly   178 GGYDRYKG--NSYEFNPTSSESNKDNGD--------------------LTGIID----------- 209
            ||...::|  ..:.....:|||::|.|.                    |||..|
Mouse   154 GGRGSFRGCRGGFGLGRPNSESDQDQGTQRGGGLFGSRKPAASDSVQCLTGNGDTYQSRSGSGRG 218

  Fly   210 -WEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIERIR-------EENNKITVSY-- 264
             ::.||:..:..:.          ||.:|...|....:.|:..::.       |:.:.|...|
Mouse   219 GYKGLNEEVVTGSG----------KNSWKSETEGGESSDSQGPKVTYIPPPPPEDEDSIFAHYQT 273

  Fly   265 ---------VFEPKEGETSPPIPNPVWTFEQ---CFAEYPDMLEEITKMGFSKPSPIQSQAWPIL 317
                     :.....|..:||   .:.|||:   |    ..:...|.|.|::|.:|:|..:.||:
Mouse   274 GINFDKYDTILVEVSGHDAPP---AILTFEEANLC----QTLNNNIAKAGYTKLTPVQKYSIPIV 331

  Fly   318 LQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRGTRGGANV-----------LVLAPTRELAL 371
            |.|.|::..||||:|||.|||||.:.|.        .|.|...           :::||||||..
Mouse   332 LAGRDLMACAQTGSGKTAAFLLPILAHM--------MRDGITASRFKELQEPECIIVAPTRELIN 388

  Fly   372 QIEMEVKKYSF-RGMKAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLV 435
            ||.:|.:|:|| ..::||.:|||......:..:.:|..|:..|||||.|:|....|.:..:.|||
Mouse   389 QIYLEARKFSFGTCVRAVVIYGGTQFGHSVRQIVQGCNILCATPGRLMDIIGKEKIGLKQVKYLV 453

  Fly   436 LDEADRMLDMGFEPQIRKVM----LDIRPDRQTIMTSATWPPGVRRLAQSYMKNP-IQVCVGSLD 495
            ||||||||||||.|:::|::    :..:..|||::.|||:|..::|||..::|:. :.|.||.:.
Mouse   454 LDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLLFSATFPEEIQRLAGDFLKSSYLFVAVGQVG 518

  Fly   496 LAATHSVKQIIKLMEDDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIH 560
             .|...|:|.| |......|...:...::|:.. ::.::|...|.:||.:::.|..:...|..||
Mouse   519 -GACRDVQQTI-LQVGQYSKREKLVEILRNIGD-ERTMVFVETKKKADFIATFLCQEKISTTSIH 580

  Fly   561 GNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGR 625
            |:|:|.:||||:.|.:.|...:||||.||:||||||::.||||:|.|..|:|||||:|||||.|.
Mouse   581 GDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGN 645

  Fly   626 QGTSISFF-TREDWAMAKELIEILQEAEQEVPDELHNMA 663
            .|.:|||| |..|..:|:.|:::|.:|:|:||..|..:|
Mouse   646 TGRAISFFDTDSDNHLAQPLVKVLSDAQQDVPAWLEEIA 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH_1	92..152	CDD:459630	7/59 (12%)
		DEAD-like_helicase_N	174..663	CDD:475120	182/561 (32%)
Ddx4	XP_011242920.1	DEADc_DDX4	266..518	CDD:350810	93/266 (35%)
		SF2_C_DEAD	524..653	CDD:350174	56/130 (43%)