DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7878 and Ddx3x

DIOPT Version :10

Sequence 1:NP_649767.1 Gene:CG7878 / 40959 FlyBaseID:FBgn0037549 Length:703 Species:Drosophila melanogaster
Sequence 2:NP_034158.1 Gene:Ddx3x / 13205 MGIID:103064 Length:662 Species:Mus musculus


Alignment Length:736 Identity:228/736 - (30%)
Similarity:330/736 - (44%) Gaps:188/736 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 PNYVEKPAVHQEYSKPNNKYERSIRRDGNSRAYK--GDRNDYGGEGRGYRAKRNDYGGGRRDNRD 71
            |:...:.|....|.|.::.:..|..:|    ||.  |.|    |:.||..:...|.|.|.|...|
Mouse    41 PHLRNREATKGFYDKDSSGWSSSKDKD----AYSSFGSR----GDSRGKSSFFGDRGSGSRGRFD 97

  Fly    72 NYGAGHRDSRDSAGGGGGDFSESLSIASEMVGKVIGRGGSNISRIQNDFNVRVKLDKCDLIVKIT 136
            :.|.|..|..    ||.||.|.        .|| ..|||::                        
Mouse    98 DRGRGDYDGI----GGRGDRSG--------FGK-FERGGNS------------------------ 125

  Fly   137 GSIQSNVIDAINHVRKQVTNSGDRGQDRDNRDHGSNERYDGGGYDRYKGNSYEFNPTSSESNKD- 200
                                   |..|:.:.|..|...                 |.|....:: 
Mouse   126 -----------------------RWCDKSDEDDWSKPL-----------------PPSERLEQEL 150

  Fly   201 -NGDLTGIIDWEALNKASIAATAARWSKCPPLTKNFYKEAPEVANLTKSEIERIREENNKITVSY 264
             :|..|| |::|..:...:.||.   :.|||..::|            |::|.     .:|.:..
Mouse   151 FSGGNTG-INFEKYDDIPVEATG---NNCPPHIESF------------SDVEM-----GEIIMGN 194

  Fly   265 VFEPKEGETSPPIPNPVWTFEQCFAEYPDMLEEITKMGFSKPSPIQSQAWPILLQGHDMIGIAQT 329
            :                               |:|:  :::|:|:|..|.||:.:..|::..|||
Mouse   195 I-------------------------------ELTR--YTRPTPVQKHAIPIIKEKRDLMACAQT 226

  Fly   330 GTGKTLAFLLPGMIHTEYQSTP---------RGTRGGAN----VLVLAPTRELALQIEMEVKKYS 381
            |:|||.||||| ::...|...|         .|..|...    .||||||||||:||..|.:|:|
Mouse   227 GSGKTAAFLLP-ILSQIYADGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFS 290

  Fly   382 FRGMKAVC-VYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITYLVLDEADRMLDM 445
            :|.....| ||||.....||.|||||..:::.|||||.|::....|.:....|||||||||||||
Mouse   291 YRSRVRPCVVYGGAEIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDM 355

  Fly   446 GFEPQIRKVM-LDIRPD---RQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAATHSVKQII 506
            |||||||::: .|..|.   |.|:|.|||:|..::.||:.::...|.:.||.:...:.:..::::
Mouse   356 GFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVV 420

  Fly   507 KLMEDDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNRDQMDREQA 571
            .:  :::||.:.:...:.........::|...|..||.|...|..:|:....|||:|.|.|||:|
Mouse   421 WV--EEIDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEA 483

  Fly   572 IADIKSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGTSISFFTRE 636
            :...:||...|||||.||:|||||.::.||||:|.|.:|||||||:|||||.|..|.:.|||...
Mouse   484 LHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNER 548

  Fly   637 DWAMAKELIEILQEAEQEVPDELHNMA--RRFKAM---KDKRAAEGGGFGGR------------- 683
            :..:.|:|:::|.||:||||..|.|||  ..:|..   :.|.:...||||.|             
Mouse   549 NINITKDLLDLLVEAKQEVPSWLENMAFEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSF 613

  Fly   684 ------GGRFGGGRGGGRRNF 698
                  ..|.|||..||.|.|
Mouse   614 SSSRASSSRSGGGGHGGSRGF 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7878NP_649767.1 KH_1 92..152 CDD:459630 6/59 (10%)
DEAD-like_helicase_N 174..663 CDD:475120 176/508 (35%)
Ddx3xNP_034158.1 Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000250|UniProtKB:O00571 2..139 35/165 (21%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:O00571 12..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..144 36/187 (19%)
Interaction with EIF4E. /evidence=ECO:0000250|UniProtKB:O00571 38..44 1/2 (50%)
Interaction with GSK3B. /evidence=ECO:0000250|UniProtKB:O00571 100..662 210/669 (31%)
Interaction with IKBKE. /evidence=ECO:0000250|UniProtKB:O00571 100..110 4/13 (31%)
Interaction with CHUK. /evidence=ECO:0000250|UniProtKB:O00571 139..172 8/50 (16%)
DEADc_DDX3 160..410 CDD:350809 104/303 (34%)
Q motif 180..208 8/77 (10%)
Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding. /evidence=ECO:0000250|UniProtKB:O00571 250..259 0/8 (0%)
DEAD box 347..350 2/2 (100%)
SF2_C_DEAD 415..545 CDD:350174 53/131 (40%)
Interaction with NXF1. /evidence=ECO:0000250|UniProtKB:O00571 536..661 33/99 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..633 6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

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