Protein Alignment CG7878 and DDX17

DIOPT Version :10

• Sequence 1: NP_649767.1
• Gene: CG7878 / 40959
• FlyBaseID: FBgn0037549
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_001091974.1
• Gene: DDX17 / 10521
• HGNCID: 2740
• Length: 731
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 232/569 - (40%)
• Similarity: 326/569 - (57%)
• Gaps: 83/569 - (14%)

  Fly   158 GDRGQDRDNRDHGSNERYDGGGYDRYKGNSYEFNPTSSESNKDNGDLTGIIDWEALNKASIAATA 222
            |||.:|||....|:.   .|||....|     |........|...||
Human    86 GDRDRDRDRGGFGAR---GGGGLPPKK-----FGNPGERLRKKKWDL------------------ 124

  Fly   223 ARWSKCPPLTKNFYKEAPEVANLTKSEIERIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQC 287
               |:.|...||||.|.||||.||..|::.:|.: .:|||      :.|:.   .|.||:.|..
Human   125 ---SELPKFEKNFYVEHPEVARLTPYEVDELRRK-KEITV------RGGDV---CPKPVFAFHH- 175

  Fly   288 FAEYPD-MLEEITKMGFSKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTP 351
             |.:|. :::.:....|::|:|||.|.:|:.|.|.||:||||||:|||||:|||.::|..:|  |
Human   176 -ANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQ--P 237

  Fly   352 RGTRG-GANVLVLAPTRELALQIEMEVKKY-SFRGMKAVCVYGGGNRNMQISDLERGAEIIICTP 414
            ...|| |...||||||||||.|::.....| ....:|:.|:|||..:..||.|||||.||.|.||
Human   238 YLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATP 302

  Fly   415 GRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEPQIRKVMLDIRPDRQTIMTSATWPPGVRRLA 479
            |||.|.:.:...::...||||||||||||||||||||||::..|||||||:|.|||||..||:||
Human   303 GRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLA 367

  Fly   480 QSYMKNPIQVCVGSLDLAATHSVKQIIKL-MEDDMDKFNTITSFVKNM--SSTDKIIIFCGRKVR 541
            :.::::..|:.||:|:|:|.|::.||:.: ||.:.|  :.:...::.:  ...:|.|||...|.|
Human   368 EDFLRDYTQINVGNLELSANHNILQIVDVCMESEKD--HKLIQLMEEIMAEKENKTIIFVETKRR 430

  Fly   542 ADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYDF 606
            .|||:..:..||:...||||::.|.:|:..:.:.:||...||:||||||||||:||:..|||||:
Human   431 CDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDY 495

  Fly   607 PHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKELIEILQEAEQEVPDELHNMARRFKAMKD 671
            |::.|:||||:|||.|:..:||:.:|||..:...|:|||::|:||.|.:..:|..:.       |
Human   496 PNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLV-------D 553

  Fly   672 KRAAEGGGFGGRGG-----------------------RFGGGRGGGRRN 697
            .|.  |||.||:||                       |..|.:.||||:
Human   554 HRG--GGGGGGKGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRD 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH_1	92..152	CDD:459630
		DEAD-like_helicase_N	174..663	CDD:475120	210/494 (43%)
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..115		12/36 (33%)
		DEAD-like_helicase_N	111..581	CDD:475120	214/515 (42%)
		Q motif	171..199		7/29 (24%)
		DEAD box	325..328		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..731
		Interaction with YAP1. /evidence=ECO:0000269|PubMed:24581491	720..728