DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7878 and ddx43

DIOPT Version :9

Sequence 1:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_001315122.1	Gene:	ddx43 / 100136871	ZFINID:	ZDB-GENE-080204-77	Length:	719	Species:	Danio rerio

Alignment Length:	734	Identity:	338/734 - (46%)
Similarity:	461/734 - (62%)	Gaps:	83/734 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DWDDP------------NYVEKPAVHQEYSKPNNKYERSIRRDGNSRAYKGDRNDYGGEGR---G 54
            ||:|.            ....|||..:.:..|:.:..|:  |:.:|...|     :||:|.   .
Zfish     3 DWEDEYDGDGVAVSKQLTLPAKPAPVKSWRPPSPRGARN--RETSSAGAK-----FGGDGEQWVN 60

  Fly    55 YRAKRNDY----GGGRRDN---RDNYG----AGHRDSRDSAGGGGGDFSESLSIASEMVGKVIGR 108
            :|.:.:|:    |...::|   |...|    .|:.|..||:       |.:|::.:.:||::|||
Zfish    61 WRNRDSDFDVFDGAAGKNNSYSRSRIGPTRSRGYADRGDSS-------SVTLNVENSLVGRIIGR 118

  Fly   109 GGSNISRIQNDFNVRVKLDK--CDLIVKITGSIQS-----NVIDAINHVRKQVTNSGDRGQDRDN 166
            ||:.|..:|......:|:.:  .:..|.|.||..:     ::|:.:.|     .|.|..|....|
Zfish   119 GGAKIRELQESSGASIKITRGAHEAEVLICGSCDAQHKAKDMIEDLVH-----ENMGGSGYRNGN 178

  Fly   167 RDHGSNERYDGGGYDRYKGNSYEFNPTSSESNKDNGDLTGIIDWEALNKASIAATAARWSKCPPL 231
            ...|            |:.||. ::.::.::..........|||.:|.:......|.:|...|.|
Zfish   179 SSQG------------YQNNSC-WSASAVKAAAAAAPAPTPIDWTSLRENRDKYEAMKWQDLPVL 230

  Fly   232 TKNFYKEAPEVANLTKSEIERIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQCFAEYPDMLE 296
            .||||.||..||..:..|::..|:|||.|   :|.:.|:|: ...|||||.|||:.||.||.::|
Zfish   231 KKNFYIEAKSVAARSAEEVKIWRKENNNI---FVDDLKDGD-KRTIPNPVCTFEEAFAHYPGIME 291

  Fly   297 EITKMGFSKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQSTPRGTRGGANVL 361
            .|.::||.||:||||||||::|.|.|:|||||||||||||:||||.||.:.|..||..|.|..:|
Zfish   292 NIVRVGFKKPTPIQSQAWPVVLNGIDLIGIAQTGTGKTLAYLLPGFIHMDGQPMPRDKRNGPGML 356

  Fly   362 VLAPTRELALQIEMEVKKYSFRGMKAVCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVI 426
            ||.||||||||||.|..|||::|.|::|:||||:||.||..:..|.:|:|.||||||||.|..:|
Zfish   357 VLTPTRELALQIEAECNKYSYKGFKSICIYGGGDRNAQIKVVTSGVDIVIATPGRLNDLQMNELI 421

  Fly   427 DVSTITYLVLDEADRMLDMGFEPQIRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCV 491
            ::.:|||||||||||||||||||||.|::|||||||||:||||||||||||||:||:|:|:.|.|
Zfish   422 NLRSITYLVLDEADRMLDMGFEPQIMKIILDIRPDRQTVMTSATWPPGVRRLAKSYLKDPMMVYV 486

  Fly   492 GSLDLAATHSVKQIIKLMEDDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMT 556
            |:|||||.::|:|.:..:::| :|.:.:..|:..|...||::||.|:|::||||||:|.|.|...
Zfish   487 GTLDLAAVNTVQQTVLFVQED-EKKDYVFDFIHRMEPLDKVLIFVGKKLKADDLSSDLCLQGIAV 550

  Fly   557 QCIHGNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTG 621
            |.:||:|:|.|||:|:.|.|.|.||||||||:||||||:.|||||.|||||.|:|||||||||||
Zfish   551 QSLHGDREQCDREEALQDFKDGRVRILVATDLASRGLDVHDITHVFNYDFPRNVEEYVHRVGRTG 615

  Fly   622 RAGRQGTSISFFTREDWAMAKELIEILQEAEQEVPDELHNMARRFKAMKDKRAAE---------- 676
            ||||.|.|::..|||||.:|.|||.||:.:.|:||:||..||.|::  |.:|..|
Zfish   616 RAGRSGESVTLVTREDWRVAAELITILERSGQDVPEELVLMAERYE--KHRREKEMFGPRSGRGG 678

  Fly   677 GGGFGGRGGRFGGGRGGGR 695
            |||.|||||.:||| ||||
Zfish   679 GGGGGGRGGGWGGG-GGGR 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7878	NP_649767.1	KH-I	92..150	CDD:238053	17/64 (27%)
		DEADc	288..489	CDD:238167	135/200 (68%)
		DEXDc	298..505	CDD:214692	139/206 (67%)
		Helicase_C	514..624	CDD:278689	67/109 (61%)
ddx43	NP_001315122.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581497
Domainoid	1	1.000	250	1.000	Domainoid score	I2080
eggNOG	1	0.900	-	-		E2759_KOG0336
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	594	1.000	Inparanoid score	I937
OMA	1	1.010	-	-		QHG45820
OrthoDB	1	1.010	-	-		D257031at33208
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		oto39197
orthoMCL	1	0.900	-	-		OOG6_106450
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4424
SonicParanoid	1	1.000	-	-		X4523
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800