DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puc and SSH3

DIOPT Version :9

Sequence 1:	NP_524273.1	Gene:	puc / 40958	FlyBaseID:	FBgn0243512	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_060327.3	Gene:	SSH3 / 54961	HGNCID:	30581	Length:	659	Species:	Homo sapiens

Alignment Length:	306	Identity:	83/306 - (27%)
Similarity:	125/306 - (40%)	Gaps:	67/306 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 ASPVFPHLLLGNGRDADDPSSVGANCV---LNVTCQSPNESHLQGLKYMQIPASDTPHQNIKQYF 195
            ||.:||||.||:..:|.:...:..|.|   ||:..:..| .:.:...|..:...|.....:..::
Human   329 ASRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDN-FYPERFTYHNVRLWDEESAQLLPHW 392

  Fly   196 QEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPIISPNLNFM 260
            :|.:.|||.||..|:.||:||..|:||||...:||.|:....||.:|.:.|:..|||..||..|:
Human   393 KETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQELRPIARPNPGFL 457

  Fly   261 GQLLELEQNL-----------RKSGVLAP---ATPHLNSPSNPSSSSVGLSTQSSQLVEQPEEEE 311
            .| |::.|.:           :|.|.::|   ..|.:::|..|.               .||.|.
Human   458 RQ-LQIYQGILTASRQSHVWEQKVGGVSPEEHPAPEVSTPFPPL---------------PPEPEG 506

  Fly   312 KREQRERGKSKSDSEAMDEDGFDYDDVDSGSGSLAGSNCSSRLTSPPITPDDEAPSTSAAASSVS 376
            ..|::..|..:|.:...:|.|      .....:|.|...|..|..|.:
Human   507 GGEEKVVGMEESQAAPKEEPG------PRPRINLRGVMRSISLLEPSL----------------- 548

  Fly   377 ELDSPSSTSSSSGICSLLQSTSSSVSPRAISKPNLLSPTRQLALFK 422
            ||:|.|.||....:.|  ...||...|        |.|..|||..|
Human   549 ELESTSETSDMPEVFS--SHESSHEEP--------LQPFPQLARTK 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puc	NP_524273.1	DSPc	133..267	CDD:238073	47/135 (35%)
puc	NP_524273.1	CDC14	<193..272	CDD:225297	32/89 (36%)
SSH3	NP_060327.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		SSH-N	3..259	CDD:212166
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..96
		DEK_C	272..320	CDD:285919
		DSPc	329..464	CDD:238073	47/136 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..534		12/72 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..603		16/65 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..638
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850