DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment puc and Ssh2

DIOPT Version :9

Sequence 1:NP_524273.1 Gene:puc / 40958 FlyBaseID:FBgn0243512 Length:476 Species:Drosophila melanogaster
Sequence 2:XP_006533290.1 Gene:Ssh2 / 237860 MGIID:2679255 Length:1450 Species:Mus musculus


Alignment Length:658 Identity:129/658 - (19%)
Similarity:217/658 - (32%) Gaps:227/658 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 ATSTARNNNSHNG----------RCECDGDGDSVSHIQSEMKMRIKR-EAPCLLLFMPIQNTNNN 74
            |...||.:|.:.|          ....:.|..||:...:...::..| ::|.|...:|.:.....
Mouse   214 ACEVARMHNYYPGSLFLTWVSYYESHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTE 278

  Fly    75 NRIGANQKDYPNKRSRENLACDEVTSTTSSSTAMN-------GGGRTPALTRSCSSPAVYDIETH 132
            ..|....::...::..||:...|:.:........|       .......:.....||        
Mouse   279 RLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSP-------- 335

  Fly   133 PASPVFPHLLLG---NGRDADDPSSVGANCVLNVTCQSPNESHLQGL-KYMQIPASDTPHQNIKQ 193
              :.:|.|:.||   |..:.:|..:.|...:||||.:..|  ...|: :|..|...|....::..
Mouse   336 --TQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDN--FFPGVFEYHNIRVYDEEATDLLA 396

  Fly   194 YFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPIISPNLN 258
            |:.:.|.||..|:|.||:.|:||..|:||||:..|||.|:....:|..||..||..|.:..||.:
Mouse   397 YWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPS 461

  Fly   259 FMGQLLELEQNLRKSGVLAPATPHLN------SPSNPSS------------SSVGLSTQSSQLVE 305
            ||.||.|.:      |:|..:....|      |.|:.|.            :...::|.:.|:.|
Mouse   462 FMRQLEEYQ------GILLASKQRHNKLWRSHSDSDLSDHHEPICKPGLELNKKEMTTSADQIAE 520

  Fly   306 --------------------QPEEEEKREQRER-----GKSKSDSEAMDEDGFDYDDVDSGS--- 342
                                |...::....:||     ..|:.......||..:.:|::..|   
Mouse   521 VKTVENLAAMPTVFMEHVVPQDANQKGLHTKERVICLEFSSQEFRAGQIEDELNLNDINGCSSGC 585

  Fly   343 ----GSLAGSNC----------------------------------------------SSRLTSP 357
                ..|...||                                              :|||...
Mouse   586 CLSESKLPLDNCHASKALLQPGQAPDIANKFPDLAVEDLETDALKADMNVHLLPMEELTSRLKDL 650

  Fly   358 PITPDDEAPSTSAAA-SSVSEL-------------------DSPSSTSSSSGI----------CS 392
            |::||.|:||..|:. :::|:.                   ::.|.:.|.|.|          |.
Mouse   651 PMSPDLESPSPQASCQAAISDFSTDRIDFFSALEKFVELSQETRSRSFSHSRIEELGGGRSEGCR 715

  Fly   393 L--------------LQSTSSSVSPRAISKPN-----------LLSPTRQLALFKRNS------- 425
            |              .:|:|.|.:|.|..:.:           |:||...:.....|:       
Mouse   716 LSVIEVAASEMAADDQRSSSLSNTPHASEESSVDEDQSKAITELVSPDIIMQSHSENAISVKEIV 780

  Fly   426 -----------PAKLRLDLESS--YAPASPIPNTMPWLSVPSTPVCEEAPDSRINH--------- 468
                       ..:|:.|:.|:  :.|.....:.:|...||       ||:|:..|         
Mouse   781 TEIESISQGVGQVQLKGDILSNPCHTPKKSTIHELPLERVP-------APESKPGHWEQDESFCS 838

  Fly   469 VASNLTRD 476
            |...|.||
Mouse   839 VQPELARD 846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pucNP_524273.1 DSPc 133..267 CDD:238073 49/137 (36%)
CDC14 <193..272 CDD:225297 33/78 (42%)
Ssh2XP_006533290.1 SSH-N 40..263 CDD:212166 9/48 (19%)
DEK_C 277..329 CDD:370106 5/51 (10%)
DSP_slingshot_2 332..475 CDD:350417 53/160 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1716
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1576308at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2281
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.850

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