DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puc and Epm2a

DIOPT Version :9

Sequence 1:	NP_524273.1	Gene:	puc / 40958	FlyBaseID:	FBgn0243512	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001263691.1	Gene:	Epm2a / 114005	RGDID:	71047	Length:	331	Species:	Rattus norvegicus

Alignment Length:	157	Identity:	32/157 - (20%)
Similarity:	58/157 - (36%)	Gaps:	30/157 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 YDIETHPA---SPVFPHLLLGN-GRDADDPS-----SVGANCVLNVTCQ---SPNESHL------ 173
            ::|..|.|   |.:.|::.||: .|..:..:     .:|...|:|...:   ..|.|..
  Rat   147 FNIAGHQAMHYSRILPNIWLGSCPRQLEHVTIKLKHELGITAVMNFQTEWDIIQNSSGCNRYPEP 211

  Fly   174 ------------QGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATI 226
                        :||.|:.:|..|...:...|...:|...:....:.|..|.:||:||:.||...
  Rat   212 MTPDTMMKLYKEEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCNAGVGRSTAA 276

  Fly   227 AIAYVMRYKSLSLLEAYKLVKVARPII 253
            ...::......||.:....:...||.:
  Rat   277 VCGWLHYVIGWSLRKVQYFIMAKRPAV 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puc	NP_524273.1	DSPc	133..267	CDD:238073	30/151 (20%)
puc	NP_524273.1	CDC14	<193..272	CDD:225297	14/61 (23%)
Epm2a	NP_001263691.1	CBM20_laforin	1..129	CDD:99881
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95278	103..107
		PTPc	158..304	CDD:304379	29/146 (20%)
		Glucan phosphatase signature motif CXAGXGR. /evidence=ECO:0000250\|UniProtKB:O95278	266..272		3/5 (60%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95278	267..272		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900