DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7900 and FAAH2

DIOPT Version :9

Sequence 1:	NP_001097707.1	Gene:	CG7900 / 40957	FlyBaseID:	FBgn0037548	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_777572.2	Gene:	FAAH2 / 158584	HGNCID:	26440	Length:	532	Species:	Homo sapiens

Alignment Length:	542	Identity:	198/542 - (36%)
Similarity:	300/542 - (55%)	Gaps:	38/542 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RLIVILVKVIALIVSPLLEAFVY--RPKSKRTLIPPIRSRLLTLSVQELRRRLQSRQLTSVELVR 68
            |:.:.|::.:..::..:..|.:.  .||.......|:...||.||..:|.:.::.|::..:::|:
Human     8 RIQLFLLRALGFLIGLVGRAALVLGGPKFASKTPRPVTEPLLLLSGMQLAKLIRQRKVKCIDVVQ 72

  Fly    69 TYIERIEAVNKHLNALIESRFTAALEEATETDDLIASCQTAAEVEKLFEER-PLLGLPVTIKESC 132
            .||.||:.||..:|.:::.||..|::||...|..:|..|   |.|...|.: |.||:|:|:||:.
Human    73 AYINRIKDVNPMINGIVKYRFEEAMKEAHAVDQKLAEKQ---EDEATLENKWPFLGVPLTVKEAF 134

  Fly   133 ALEGMTFAVGSLSRKNIKAEADGEAVKRLKLAGAIPLLVSATPEYCFSIETDTLLNGRCLNPYDS 197
            .|:||..:.|.::|::..|:.|...|..||.||||||.::...|.|...|:...:.||..||||.
Human   135 QLQGMPNSSGLMNRRDAIAKTDATVVALLKGAGAIPLGITNCSELCMWYESSNKIYGRSNNPYDL 199

  Fly   198 ERTSGGSSGGEGSLNGAGASLFGIGSDIGGSIRIPSLYCGIFGHKPSGGVVSVKGHFPNSLDPNI 262
            :...||||||||....|..|:.|:|||||||||:|:.:.||||||||.|||..||.||.:    :
Human   200 QHIVGGSSGGEGCTLAAACSVIGVGSDIGGSIRMPAFFNGIFGHKPSPGVVPNKGQFPLA----V 260

  Fly   263 GH---YLVEGPITRFAEDLSELLQVMAGKENSSKLRLNEPVQLNQIKVQYALAFEGINGWMHMAV 324
            |.   :|..||:.|:||||:.:|:|||| ....:|:|:..|.|..:|. |.:..:| ..::...|
Human   261 GAQELFLCTGPMCRYAEDLAPMLKVMAG-PGIKRLKLDTKVHLKDLKF-YWMEHDG-GSFLMSKV 322

  Fly   325 DKDITGAICKATTHLKT-LGLNVKKVKLPNLENSVE-----MALSGIAGQDLMDY--LLTDENPE 381
            |:|:.....|...||:| ||.:|:.|||..::.|.:     |:..|..|::.:.:  ||.|.
Human   323 DQDLIMTQKKVVVHLETILGASVQHVKLKKMKYSFQLWIAMMSAKGHDGKEPVKFVDLLGDH--- 384

  Fly   382 GSGKVRETVWEIVKSVRGHSKYTTN----ALIFELMRRTGAFMSQSKINQYMKETRELIGEFENL 442
              ||....:||::|...|.|.||..    ||:.|.:|     .|..|..::......|..|..::
Human   385 --GKHVSPLWELIKWCLGLSVYTIPSIGLALLEEKLR-----YSNEKYQKFKAVEESLRKELVDM 442

  Fly   443 LGDNGVLLFPTLNLPAPRHKWSILSLWGVDYTLMFNVLGLPVTHVPMGLNERGLPIGLSVIGAPN 507
            |||:||.|:|:....||:|...:...:...||.:|:.||||||..|:|||.:|||:|:.|:..|.
Human   443 LGDDGVFLYPSHPTVAPKHHVPLTRPFNFAYTGVFSALGLPVTQCPLGLNAKGLPLGIQVVAGPF 507

  Fly   508 QDRLCLRVAVELERAFGGWKPP 529
            .|.|.|.||..||:.||||..|
Human   508 NDHLTLAVAQYLEKTFGGWVCP 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7900	NP_001097707.1	PRK07488	44..530	CDD:236030	192/502 (38%)
CG7900	NP_001097707.1	GatA	47..531	CDD:223232	190/499 (38%)
FAAH2	NP_777572.2	GatA	48..526	CDD:223232	189/497 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.880