DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7910 and faah

DIOPT Version :9

Sequence 1:	NP_001287222.1	Gene:	CG7910 / 40956	FlyBaseID:	FBgn0037547	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001103295.1	Gene:	faah / 569067	-ID:	-	Length:	590	Species:	Danio rerio

Alignment Length:	589	Identity:	148/589 - (25%)
Similarity:	249/589 - (42%)	Gaps:	147/589 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NKILDFVLPRQK---------PKFSGIRNP------LLKKSVVELVTQLRRGEITSVELVSAYIA 69
            ||||:....|.|         .:|. |:||      ::..|:.||..:|:.|.:....::.|::.
Zfish    45 NKILNARRRRDKSLQQAEQAVQRFK-IQNPGFESSSIVSLSLSELTGKLQDGSLQPDAVLYAFME 108

  Fly    70 RVQEVNPSLNAVVEDRFEAALQDAKLADQFIEKASSEFDRVALYTKYPILGVPFTVKESCGLKGL 134
            :..|||.:||...|...|:.   |:|.|...:|            |..:.|||.::|::.|.||.
Zfish   109 KTLEVNRNLNCGTEMLMESV---AQLKDMNTQK------------KGLLYGVPISIKDNFGYKGH 158

  Fly   135 SFAVGSLARKNMKAPQDGDVVELVRAAGGIPLLVSANPEFCMSFETSNNIQGRCLNPYDLQRTSA 199
            ..:.|.:::.:..|..|..:|.:::..|.||.:.:..|:..::::..|.|.|:.||||:||:||.
Zfish   159 DSSCGVVSKLDQPAVMDSVIVTVLKKQGAIPFIKTNIPQGLLNYDCGNPIFGQTLNPYNLQKTSG 223

  Fly   200 GSSGGEASLNGCGATTFGVGSDISGSIRLPALFCGVFGHKPTG------GL-TSVKGHFPYSLTD 257
            ||||||.:|.|.|.:..|:|:||.||||:|:.|||:.|.|||.      |: |.|||
Zfish   224 GSSGGEGALIGGGGSILGLGTDIGGSIRIPSAFCGICGFKPTARRLSTRGIDTCVKG-------- 280

  Fly   258 KKFSEMLQIGPITRFARDLPLLLEIMAGDKKHKLKMSEPVALKDMKVYYA-----FGYSGFNCLT 317
             :.|.:..|||:.|....|.|.:..:.......|..:.|....:.:||.:     .||...:...
Zfish   281 -QKSVLSSIGPLARDVESLALCMRALLCQDMFSLDPTIPPLPFNQEVYESSKPLRIGYYETDGYL 344

  Fly   318 HPVVDFDIKLAITKAVTCLERGG---VQSKKLDLKFLRNSLEIALVSLV---------DLKGLPS 370
            .|  ...:..|:.:....|||.|   |..:.|.|..:.:  |:||..::         .||..|
Zfish   345 QP--SPSMARAVRETKELLERAGHTFVPFQPLRLYNIFH--ELALRGILGDGGETLFSHLKAGP- 404

  Fly   371 IVTQRADRDPSMRLLMVELFNSIIGHSIFTKEAMVLEVMKRF--------NGLMATGNMEEYRVE 427
                   .||.:....|.|     |...|.:: |:..::|.|        :|....|::.|...:
Zfish   405 -------LDPCLCSQPVTL-----GSPRFIRK-MLSFLIKPFFPRISASLHGTCGLGSVAELWRQ 456

  Fly   428 AQKIKSHLNQLLG-----TQGVLIMP------TFH-----TSALCFHTSLLNVTGIDNLLLFNIL 476
            ...::.::.:::.     ...:|:.|      .||     .|||.:.|            |:|:|
Zfish   457 HANVEEYIQEVIAEWRRLDVDILLCPILGPAFNFHYCGRLNSALSYTT------------LYNLL 509

  Fly   477 GLPATHVPMGTNQR-----------------------------GMPIGLQVVAAQYQDKLCLKVA 512
            ..||..|.:.....                             |:|:.:|.|:..:||::||:..
Zfish   510 NFPAGVVCVSAVTEDDEAQLRQYTGAHGDPWDKLFQQAVKGGVGLPVAVQCVSLPWQDEMCLRFM 574

  Fly   513 AELE 516
            .|:|
Zfish   575 REVE 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7910	NP_001287222.1	GatA	41..527	CDD:223232	138/553 (25%)
CG7910	NP_001287222.1	PRK07488	41..525	CDD:236030	138/553 (25%)
faah	NP_001103295.1	Amidase	101..571	CDD:302749	129/523 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575750
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1914
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.780