DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7910 and QRSL1

DIOPT Version :9

Sequence 1:	NP_001287222.1	Gene:	CG7910 / 40956	FlyBaseID:	FBgn0037547	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_060762.3	Gene:	QRSL1 / 55278	HGNCID:	21020	Length:	528	Species:	Homo sapiens

Alignment Length:	539	Identity:	126/539 - (23%)
Similarity:	215/539 - (39%)	Gaps:	107/539 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LLKKSVVELVTQLRRGEITSVELVSAYIARVQEVNPSLNAVVEDRFEAALQDAKLADQFIEKASS 105
            :|.:|:.|:...|::|:||..||....::.:::.. .|||.:....|.||:.|:.:::..:...|
Human     1 MLGRSLREVSAALKQGQITPTELCQKCLSLIKKTK-FLNAYITVSEEVALKQAEESEKRYKNGQS 64

  Fly   106 EFDRVALYTKYPILGVPFTVKESCGLKGLSFAVGSLARKNMKAPQDGDVVELVRAAGGIPLLVSA 170
            ..|         :.|:|..||::....|:.....|...|....|.:..||:.:...|.:.:..:.
Human    65 LGD---------LDGIPIAVKDNFSTSGIETTCASNMLKGYIPPYNATVVQKLLDQGALLMGKTN 120

  Fly   171 NPEFCMSFETSNNIQGRCLNPYDLQR--------------------TSAGSSGGEASLNGCGATT 215
            ..||.|...:::.:.|...||:...:                    .:.|||||.|:........
Human   121 LDEFAMGSGSTDGVFGPVKNPWSYSKQYREKRKQNPHSENEDSDWLITGGSSGGSAAAVSAFTCY 185

  Fly   216 FGVGSDISGSIRLPALFCGVFGHKPTGGLTSVKGHFPYSLTDKKFSEMLQIGPITRFARDLPLLL 280
            ..:|||..||.|.||..||:.|.||:.||.|..|..|.      .:.|...|.:||...|..::|
Human   186 AALGSDTGGSTRNPAAHCGLVGFKPSYGLVSRHGLIPL------VNSMDVPGILTRCVDDAAIVL 244

  Fly   281 EIMAG-DKKHKLKMSEPV-------ALKDM--------KVYYAFGYSGFNCLTHPVVDFDIKLAI 329
            ..:|| |.:....:.||:       :|.|:        |.|..           |.:..:::...
Human   245 GALAGPDPRDSTTVHEPINKPFMLPSLADVSKLCIGIPKEYLV-----------PELSSEVQSLW 298

  Fly   330 TKAVTCLERGGVQSKKLDLKFLRNSLEIALVSLVDLKGLPSIVTQ--------RADRDPSMRLLM 386
            :||....|..|  :|.:::.....|..|....::....:.|.:.:        |.|.|.|...:.
Human   299 SKAADLFESEG--AKVIEVSLPHTSYSIVCYHVLCTSEVASNMARFDGLQYGHRCDIDVSTEAMY 361

  Fly   387 V----ELFNSIIGHSIFTKEAMVLEVMKRFNGLMATGNMEEYRVEAQKIK-----SHLNQLLGTQ 442
            .    |.||.::...|.:....:|:           .|.|.|.|:|||::     ..:|......
Human   362 AATRREGFNDVVRGRILSGNFFLLK-----------ENYENYFVKAQKVRRLIANDFVNAFNSGV 415

  Fly   443 GVLIMPTFHTSALCFHTSLLNVTGIDNLL------LF----NILGLPATHVPMGTNQRGMPIGLQ 497
            .||:.||..:.|:.:    |.....||..      :|    |:.||||..:|:..:.:|:|||||
Human   416 DVLLTPTTLSEAVPY----LEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSIPVALSNQGLPIGLQ 476

  Fly   498 VVAAQYQDKLCLKVAAELE 516
            .:...:.|:..|.||...|
Human   477 FIGRAFCDQQLLTVAKWFE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7910	NP_001287222.1	GatA	41..527	CDD:223232	126/539 (23%)
CG7910	NP_001287222.1	PRK07488	41..525	CDD:236030	126/539 (23%)
QRSL1	NP_060762.3	gatA	13..495	CDD:234572	122/525 (23%)
QRSL1	NP_060762.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..167		0/18 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810