DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7910 and CG5191

DIOPT Version :9

Sequence 1:	NP_001287222.1	Gene:	CG7910 / 40956	FlyBaseID:	FBgn0037547	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_650893.2	Gene:	CG5191 / 42431	FlyBaseID:	FBgn0038803	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	193/552 - (34%)
Similarity:	306/552 - (55%)	Gaps:	48/552 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EIILRLLAFILNAF---GMLVNKILDFVLPRQ--------KPKFSGIRNPLLKKSVVELVTQLRR 55
            |:.||:|.:|:..|   .|:|  ...||:|..        :.|...||:.||:...|:|...:|.
  Fly    15 ELWLRILGYIMRRFLRSAMIV--FSWFVVPYSRYTNIKVIRRKLPPIRSHLLEIPAVDLAKLIRT 77

  Fly    56 GEITSVELVSAYIARVQEVNPSLNAVVEDRFEAALQDAKLADQFIEKASSEFDRVALYTKYPILG 120
            .:|.|.|:|.|||.|.::|||.:||:|:||||.||::|:..|..|....:..:.:...|  |:||
  Fly    78 RKIKSEEVVEAYIERCRQVNPLINAIVQDRFEEALEEAREIDNVIAMGINSVESMEELT--PLLG 140

  Fly   121 VPFTVKESCGLKGLSFAVGSLARKNMKAPQDGDVVELVRAAGGIPLLVSANPEFCMSFETSNNIQ 185
            :|.|||||..:||::...|.:.:....|..|..|||.::.:|||.||||..||.|:.:||.||:.
  Fly   141 IPVTVKESIAVKGMTNQAGRVFKTPQIAKSDAPVVEQIKRSGGIILLVSNTPELCLLWETYNNVT 205

  Fly   186 GRCLNPYDLQRTSAGSSGGEASLNGCGATTFGVGSDISGSIRLPALFCGVFGHKPTGGLTSVKGH 250
            |:..|||||:||..|||||||:|...||:..|:.|||.||.||||:|.|::|||||....|.|||
  Fly   206 GQTKNPYDLKRTPGGSSGGEAALLASGASLLGLTSDIGGSSRLPAMFSGIWGHKPTPYAVSFKGH 270

  Fly   251 FPYSLTDKKFSEMLQIGPITRFARDLPLLLEIMAGDKKHKLKMSEPVALKDMKVYYA--FGYSGF 313
            .|.| ...|:.:...|.|:||:|:||||||:.|:.....||.:..|:::..::.::.  .|.||
  Fly   271 HPTS-DFPKWGDFFTIAPMTRYAKDLPLLLKCMSDPTGPKLTLDRPISVNGIRFFFMDNDGPSG- 333

  Fly   314 NCLTHPVVDFDIKLAITKAVTCLERGGVQSKKLDLKFLRNSLEIALVSLVDLKGLPSIV--TQRA 376
              :..| :..|:..||.:..|     ...:|:::::.::.||:|:|.:::.:|.:.:|.  |:..
  Fly   334 --MMRP-LSRDLHAAINRVAT-----DFNAKRVNIRKMKWSLDISLSAMLTMKNIETIYHKTEEG 390

  Fly   377 DRDPSMRLLMVELF----NSIIGHSIFTKEAMVLEVMKRFNGLMATGNMEEYRVEAQKIKSHLNQ 437
            ::..::....|:.|    :||:...||..       ::.|..::.....:......:.:|:...:
  Fly   391 EQPKTVCKETVKYFFGCSDSILPSVIFGH-------LQNFMKIIPNSRHKHLASIIEALKTEFKE 448

  Fly   438 LLGTQGVLIMPTF----HTSALCFHTSLLNVTGIDNLLLFNILGLPATHVPMGTNQRGMPIGLQV 498
            :||..||.:.|||    |.....:|..|..:    .:.:||.||||.|:..:|.::|.:|:|:||
  Fly   449 MLGNDGVFLYPTFPNTAHQHYQIYHKLLEPM----YMAIFNTLGLPVTNCMIGLDRRNLPMGIQV 509

  Fly   499 VAAQYQDKLCLKVAAELEAVFHGWVPPVPHDT 530
            ||...||.|.|.||.|:|..:.|||.|...|:
  Fly   510 VANPGQDHLSLAVAREMERRYGGWVRPPSEDS 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7910	NP_001287222.1	GatA	41..527	CDD:223232	178/497 (36%)
CG7910	NP_001287222.1	PRK07488	41..525	CDD:236030	177/495 (36%)
CG5191	NP_650893.2	GatA	61..537	CDD:223232	177/498 (36%)
CG5191	NP_650893.2	PRK07488	63..537	CDD:236030	177/496 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6507
eggNOG	1	0.900	-	-		E1_COG0154
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4451
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54749at33392
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	1	1.000	-	-		otm42825
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1914
SonicParanoid	1	1.000	-	-		X256
	11	10.950