DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7910 and faah-3

DIOPT Version :9

Sequence 1:	NP_001287222.1	Gene:	CG7910 / 40956	FlyBaseID:	FBgn0037547	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_500017.2	Gene:	faah-3 / 176916	WormBaseID:	WBGene00019068	Length:	570	Species:	Caenorhabditis elegans

Alignment Length:	592	Identity:	135/592 - (22%)
Similarity:	229/592 - (38%)	Gaps:	173/592 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QKPKFSGIRNPLLK-----------KSVVELVTQLRRGEITSVELVSAYIARVQEVNPSLNAV-- 81
            :|..|...:|...|           |...||...|:.|||..||.:.|:..:..|.....|.|
Worm    39 RKINFEWAKNSFQKLDESRAVEISAKPFEELRNSLKNGEIGPVETLRAFQRKAYESTEKTNCVCF 103

  Fly    82 -VEDRFEAALQDAKLADQFIEKASSEFDRVALYTKYPILGVPFTVKESCGLKGLSFAVGSLARKN 145
             :::..|.|        :.:|..:::.:    |.|.|:.|||.::|||..:|.|....|...:.|
Worm   104 FIQEALEIA--------ENLEHLATDPN----YQKPPLFGVPVSIKESIHVKNLDSTAGYAQKIN 156

  Fly   146 MKAPQDGDVV---ELVRAAGGIPLLVSANPEFCMSFETSNNIQGRCLNPYDLQRTSAGSSGGEAS 207
              .|.|.:.|   :|:| .|.:|.:.:..|...:|:..||.:.|..|||.|..|...|||||||:
Worm   157 --NPSDANSVSVDQLIR-LGAVPFVHTNIPIALLSYGCSNGVYGTTLNPLDNSRVPGGSSGGEAA 218

  Fly   208 LNGCGATTFGVGSDISGSIRLPALFCGVFGHKPT-------GGLTSVKGHFPYSLTDKKFSEMLQ 265
            |...|.:..|:|:|:.||||.||.|||:.|.|.:       |...|:.|.          ..:|.
Worm   219 LVSLGGSVLGIGTDVGGSIRTPASFCGLAGFKSSSDRSPQLGKTASIPGR----------QLLLS 273

  Fly   266 I-GPITRFARDLPLLLEIMAGDKKHKLKMSEPV-------------------ALKDMKV-YYAF- 308
            : |||   |:::.:.:|.:      :||.::|:                   :.|.:|: ||.|
Worm   274 VEGPI---AKNIDVCVEYL------RLKWNDPLLYKKDVYMPPVKFQENLYNSEKPLKIGYYTFD 329

  Fly   309 GYSGFNCLTHPVVDFDIKLAITKAVTCLERGGVQSKKLDLKFLRNSLEIALVSLVDLKGLPSIVT 373
            ||.    ...|.    .:.|:.:.|..|:..|              .|:....:.....:.||..
Worm   330 GYQ----TASPA----YQRAVRETVAVLKELG--------------HELVPFEVPQPDHMYSIFC 372

  Fly   374 QRADRDPSMRLLMVELFNSII-------------GHSI---------FTKEAMVLEVMKRFNGLM 416
            ..|..|..: .||..|.|.||             .|.|         ..:|..:::.:..
Worm   373 AGATADGGL-YLMDSLANDIIPPEADIGFPVAKLPHFIQRLLRKYWHHRRERQIIQELPH----- 431

  Fly   417 ATGNMEEYRVEAQKIKSHLNQLLGTQ-----GVLIMPTFHTSALC---FHTSLLNVTGIDNL-LL 472
               :.||.|...:||:.:.::.:...     ..|:.|.|.    |   .|.....:.|.::. .|
Worm   432 ---DTEEMRQMHEKIEDYRHEFVLAMRAKKLDALVCPAFG----CPPPHHGMPNKILGANSYPAL 489

  Fly   473 FNILGLPATHVPMGTNQR---------------------------GMPIGLQVVAAQYQDKLCLK 510
            :|::...|..||:...::                           |:|:.:|:....|::::||:
Worm   490 YNLIDFAAGTVPVTVQKQEDEVELRKMKTEDSWDRRVVTESKNCIGLPVSVQIATPPYREEMCLR 554

  Fly   511 VAAELEA 517
            :..::||
Worm   555 LLKQVEA 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7910	NP_001287222.1	GatA	41..527	CDD:223232	132/581 (23%)
CG7910	NP_001287222.1	PRK07488	41..525	CDD:236030	132/581 (23%)
faah-3	NP_500017.2	Amidase	82..553	CDD:366635	119/539 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D438196at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1914
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850