DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7910 and Faah

DIOPT Version :9

Sequence 1:	NP_001287222.1	Gene:	CG7910 / 40956	FlyBaseID:	FBgn0037547	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_034303.3	Gene:	Faah / 14073	MGIID:	109609	Length:	579	Species:	Mus musculus

Alignment Length:	549	Identity:	137/549 - (24%)
Similarity:	232/549 - (42%)	Gaps:	112/549 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 IRNP------LLKKSVVELVTQLRRGEITSVELVSAYIARVQEVNPSLNAVVEDRFEAALQDAKL 95
            ::||      ||...:::||.:|:.||::...::..|:.:..|||...|.|.          :.|
Mouse    64 LQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVT----------SYL 118

  Fly    96 ADQFIEKASSEFDRVALYTKYPILGVPFTVKESCGLKGLSFAVGSLARKNMKAPQDGDVVELVRA 160
            .|  .|...|:..|..|     :.|||.::||....||.:..:|....:.:.:..|..||::::.
Mouse   119 TD--CETQLSQAPRQGL-----LYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKL 176

  Fly   161 AGGIPLLVSANPEFCMSFETSNNIQGRCLNPYDLQRTSAGSSGGEASLNGCGATTFGVGSDISGS 225
            .|.:|.:.:..|:..:|::.||.:.|:.:||:...::..||||||.:|.|.|.:..|:|:||.||
Mouse   177 QGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGS 241

  Fly   226 IRLPALFCGVFGHKPTGGLTSVKG--HFPYSLTDKKFSEMLQIGPITRFARDLPLLLEIMAGDKK 288
            ||.|:.|||:.|.||||...|..|  ...|..|    :..|.:||:.|....|.|.::.:..:..
Mouse   242 IRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQT----AVQLSVGPMARDVDSLALCMKALLCEDL 302

  Fly   289 HKLKMSEPVALKDMKVYYA-----FGYSGFNCLTHPVVDFDIKLAITKAVTCLERGGVQSKKLDL 348
            .:|..:.|......::|.:     .||...:..|.|..  .::.|:.:....||..|    ...:
Mouse   303 FRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTP--AMRRAVMETKQSLEAAG----HTLV 361

  Fly   349 KFLRNSLEIALVSLVDLKGLPS------IVTQRAD-RDPSMRLLMVEL-----FNSIIG---HSI 398
            .||.|::..|| .::...||.|      :...:.| .||.:..|::.|     |..::.   ..:
Mouse   362 PFLPNNIPYAL-EVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPL 425

  Fly   399 FTKEAMVLEVM------KRFNGLMATGNMEEYRV------EAQKIKSHLNQLLGTQGVLIMPTFH 451
            |.:.|..|..|      |.:.   ....:|.||.      :|..:...|..:||....|..|...
Mouse   426 FPRLAAFLNSMCPRSAEKLWE---LQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRA 487

  Fly   452 TSALCFHTSLLNVTGIDNLLLFNILGLPATHVPMGT----------------------------- 487
            |.|:.:            .:|:|.|..||..||:.|
Mouse   488 TGAISY------------TVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMK 540

  Fly   488 NQRGMPIGLQVVAAQYQDKLCLKVAAELE 516
            ...|:|:.:|.||..:|::|||:...|:|
Mouse   541 KGIGLPVAVQCVALPWQEELCLRFMREVE 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7910	NP_001287222.1	GatA	41..527	CDD:223232	135/539 (25%)
CG7910	NP_001287222.1	PRK07488	41..525	CDD:236030	135/539 (25%)
Faah	NP_034303.3	Amidase	95..562	CDD:279733	124/509 (24%)
Faah	NP_034303.3	Substrate binding. /evidence=ECO:0000250	238..241		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833031
Domainoid	1	1.000	107	1.000	Domainoid score	I6507
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4451
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1914
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770