DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and HRH4

DIOPT Version :10

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:NP_067637.2 Gene:HRH4 / 59340 HGNCID:17383 Length:390 Species:Homo sapiens


Alignment Length:422 Identity:95/422 - (22%)
Similarity:163/422 - (38%) Gaps:94/422 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 DVNNT-NLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNIL 153
            |.|:| ||.|:.|                                :.:|..:::.....:.||.|
Human     3 DTNSTINLSLSTR--------------------------------VTLAFFMSLVAFAIMLGNAL 35

  Fly   154 VLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCL 218
            |:|||:||:|:|..|:||..:||.:|..:|.:|:|.|..:.| ..||.|..:|..||:.||.:|.
Human    36 VILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTL-FEWDFGKEICVFWLTTDYLLCT 99

  Fly   219 VSQYTVLLITIDRYCSVKIAAKYRSWRTRT-RVIYMVTITWIIPALLFFISIFGWEHFTGKRDLL 282
            .|.|.::||:.|||.||..|..||:..|.. :::.::...|::..|:....|...|.:..:    
Human   100 ASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDE---- 160

  Fly   283 PGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLY--AGIYKTAYDMQKRSEAKQRKMQSMVALSA 345
            ..:|...|..:  :....|..:....:.|:.|.|  ..||   :.:.||....  :.||...|:|
Human   161 GSECEPGFFSE--WYILAITSFLEFVIPVILVAYFNMNIY---WSLWKRDHLS--RCQSHPGLTA 218

  Fly   346 GAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMT 410
             ..|.:.||:....:...:.|....|:                         |.:..:|      
Human   219 -VSSNICGHSFRGRLSSRRSLSASTEV-------------------------PASFHSE------ 251

  Fly   411 PEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIG 475
             .|||.|:.......|.....:      .|...:|...:..:::|.:.:   :.|...|...|:.
Human   252 -RQRRKSSLMFSSRTKMNSNTI------ASKMGSFSQSDSVALHQREHV---ELLRARRLAKSLA 306

  Fly   476 LVFGAQAALLATRGKGNL----QKSTTNSKSI 503
            ::.|..|...|......:    ..|.|..||:
Human   307 ILLGVFAVCWAPYSLFTIVLSFYSSATGPKSV 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 56/178 (31%)
TM helix 2 168..194 CDD:320429 10/25 (40%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 3/23 (13%)
TM helix 5 293..322 CDD:320429 6/30 (20%)
7tm_GPCRs <932..1008 CDD:475119
TM helix 6 941..963 CDD:410628
TM helix 7 976..1001 CDD:410628
HRH4NP_067637.2 7tmA_Histamine_H4R 16..374 CDD:320422 88/377 (23%)
TM helix 1 17..43 CDD:320422 8/25 (32%)
TM helix 2 50..77 CDD:320422 10/26 (38%)
TM helix 3 87..117 CDD:320422 14/29 (48%)
TM helix 4 132..150 CDD:320422 2/17 (12%)
TM helix 5 171..201 CDD:320422 6/34 (18%)
TM helix 6 296..326 CDD:320422 6/29 (21%)
TM helix 7 337..362 CDD:320422 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

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