DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-B and HRH4

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_067637.2	Gene:	HRH4 / 59340	HGNCID:	17383	Length:	390	Species:	Homo sapiens

Alignment Length:	422	Identity:	95/422 - (22%)
Similarity:	163/422 - (38%)	Gaps:	94/422 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 DVNNT-NLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNIL 153
            |.|:| ||.|:.|                                :.:|..:::.....:.||.|
Human     3 DTNSTINLSLSTR--------------------------------VTLAFFMSLVAFAIMLGNAL 35

  Fly   154 VLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCL 218
            |:|||:||:|:|..|:||..:||.:|..:|.:|:|.|..:.| ..||.|..:|..||:.||.:|.
Human    36 VILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTL-FEWDFGKEICVFWLTTDYLLCT 99

  Fly   219 VSQYTVLLITIDRYCSVKIAAKYRSWRTRT-RVIYMVTITWIIPALLFFISIFGWEHFTGKRDLL 282
            .|.|.::||:.|||.||..|..||:..|.. :::.::...|::..|:....|...|.:..:
Human   100 ASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDE---- 160

  Fly   283 PGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLY--AGIYKTAYDMQKRSEAKQRKMQSMVALSA 345
            ..:|...|..:  :....|..:....:.|:.|.|  ..||   :.:.||....  :.||...|:|
Human   161 GSECEPGFFSE--WYILAITSFLEFVIPVILVAYFNMNIY---WSLWKRDHLS--RCQSHPGLTA 218

  Fly   346 GAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMT 410
             ..|.:.||:....:...:.|....|:                         |.:..:|
Human   219 -VSSNICGHSFRGRLSSRRSLSASTEV-------------------------PASFHSE------ 251

  Fly   411 PEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIG 475
             .|||.|:.......|.....:      .|...:|...:..:::|.:.:   :.|...|...|:.
Human   252 -RQRRKSSLMFSSRTKMNSNTI------ASKMGSFSQSDSVALHQREHV---ELLRARRLAKSLA 306

  Fly   476 LVFGAQAALLATRGKGNL----QKSTTNSKSI 503
            ::.|..|...|......:    ..|.|..||:
Human   307 ILLGVFAVCWAPYSLFTIVLSFYSSATGPKSV 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	60/193 (31%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	58/188 (31%)
HRH4	NP_067637.2	7tmA_Histamine_H4R	16..374	CDD:320422	88/377 (23%)
		TM helix 1	17..43	CDD:320422	8/25 (32%)
		TM helix 2	50..77	CDD:320422	10/26 (38%)
		TM helix 3	87..117	CDD:320422	14/29 (48%)
		TM helix 4	132..150	CDD:320422	2/17 (12%)
		TM helix 5	171..201	CDD:320422	6/34 (18%)
		TM helix 6	296..326	CDD:320422	6/29 (21%)
		TM helix 7	337..362	CDD:320422	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910