DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-B and chrm3a

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	XP_021328763.1	Gene:	chrm3a / 571679	ZFINID:	ZDB-GENE-090410-4	Length:	595	Species:	Danio rerio

Alignment Length:	943	Identity:	198/943 - (20%)
Similarity:	313/943 - (33%)	Gaps:	412/943 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 WPVNEQLQWYRNFDVNNTNL--LLAVRNQSSDGGSTMSGSSSDSEILGPVLPPF---ALWQTILI 136
            ||:           :.||:|  |.||        ..::||::::|  |....|.   :|||.|||
Zfish    28 WPL-----------LQNTSLVNLTAV--------FKLNGSNAEAE--GQSYDPLGGHSLWQVILI 71

  Fly   137 AICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDL 201
            .:...:..::|:.|||||:::|.|:|.::..:|||:.|||..|::||.:||..||.|::.|.|.:
Zfish    72 VVFTGLLSLITIIGNILVMVSFKVNRQLKTVNNYFLLSLAVADLIIGVISMNLYTAYIVMGQWAM 136

  Fly   202 GPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPALLFF 266
            |...|||||::||.....|...:|:|:.|||.|:.....||:.||..|...|:.:.|.:..:|:.
Zfish   137 GNWACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWFVSLILWA 201

  Fly   267 ISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSE 331
            .:|..|::|.|:|.:...:|.:|||.:||......:..::..:.::.|||..|||   :.:.||.
Zfish   202 PAILFWQYFVGQRTVPQDKCYIQFLSEPIITFCTAMAAFYLPVTIMSVLYWRIYK---ETENRSR 263

  Fly   332 AKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQA 396
                                                   ||||               |.|||
Zfish   264 ---------------------------------------ELAG---------------LQGSG-- 272

  Fly   397 NPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLIT 461
                                          .|...|:        .|.|.
Zfish   273 ------------------------------GRFGGVE--------RPRFH--------------- 284

  Fly   462 QQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQ 526
                                  |.||||      |:.:..|.|.
Zfish   285 ----------------------LHATRG------SSRSCSSFEL--------------------- 300

  Fly   527 SKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDP 591
                          .||.|              |:.|..:||
Zfish   301 --------------GQPGH--------------KKASVHSLS----------------------- 314

  Fly   592 LSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNS 656
                                        ..|.|            :|..||.|:
Zfish   315 ----------------------------GRFHC------------WGWKSGGSD----------- 328

  Fly   657 ELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQ 721
                                                     ::.|....:||.|.:.:.|.:
Zfish   329 -----------------------------------------KSGPNREADQSSSDSWNNNDA--- 349

  Fly   722 SLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPH 786
                .|:.:|:.|..:  :|:.....|.:.|                   .:|.:||..||
Zfish   350 ----GLSADHSGSSDE--DESAPSTTRAIFS-------------------IVLSLPGVRAA---- 385

  Fly   787 RRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTN 851
                                    ::.:| ||..:..|.:.        ||...||:::.|.:.
Zfish   386 ------------------------VNSQV-TSCEELDTEED--------PLRSAEEKDSRDGSI- 416

  Fly   852 KMPSTSGTTSSTGGVGGGGEQDGVGATK--KNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFK 914
               |.|.|..:...|||..:...:.|.:  .:...|..|...||.:|.....:.|    :.|.|.
Zfish   417 ---SRSVTNGNKRFVGGMSKVQSMSAIQPTTDTTTDSTNTTIKSPSAPITFKEAA----LAKRFA 474

  Fly   915 SKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINEHLY 979
            ::....:.     ::|..|..:.:||.:|:|.||..|:..||||:::.||..||.  .||.|:|:
Zfish   475 ARARTQIT-----KRKRMSLIKEKKAAQTLSAILFAFIITWTPYNIMVLVNTFCN--GCIPENLW 532

  Fly   980 MFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            ...|:|||.||.:||.||||.|:.|:.||..||
Zfish   533 ALGYWLCYVNSTVNPMCYALCNKTFRSTFKMIL 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	66/190 (35%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	66/185 (36%)
chrm3a	XP_021328763.1	7tm_GPCRs	66..>258	CDD:333717	70/194 (36%)
		TM helix 1	71..95	CDD:320095	8/23 (35%)
		TM helix 2	104..126	CDD:320095	11/21 (52%)
		TM helix 3	142..164	CDD:320095	9/21 (43%)
		TM helix 4	187..203	CDD:320095	3/15 (20%)
		TM helix 5	229..252	CDD:320095	4/22 (18%)
		7tm_GPCRs	<462..570	CDD:333717	42/115 (37%)
		TM helix 5	462..483	CDD:320095	3/29 (10%)
		TM helix 6	493..518	CDD:320095	11/24 (46%)
		TM helix 7	529..554	CDD:320095	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920