Protein Alignment mAChR-B and chrm5a

DIOPT Version :9

• Sequence 1: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_001018639.1
• Gene: chrm5a / 553978
• ZFINID: ZDB-GENE-080723-32
• Length: 490
• Species: Danio rerio
• Alignment Length: 884
• Identity: 168/884 - (19%)
• Similarity: 253/884 - (28%)
• Gaps: 441/884 - (49%)

  Fly   129 ALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIY 193
            :||:.|.||...||...:|:.|||||:|:|.|:..::..:||::.|||..|::||..||..||.|
Zfish    21 SLWEVIAIATVSAIVSFITIIGNILVMLSFKVNSQLKTVNNYYLLSLAFADLIIGVFSMNLYTSY 85

  Fly   194 VLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITW 258
            :|.|||.||.:.|||||::||.....|...:|:|:.|||.|:.....||:.||......|:.:.|
Zfish    86 ILMGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKIAGIMIGLAW 150

  Fly   259 IIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTA 323
            ::..:|:...|..|::|.|||.:...||.:||..:|:......|..::..:.|:.:||..|||..
Zfish   151 LVSFILWAPPILCWQYFVGKRTVPERQCQIQFFSEPVITFGTAIAAFYFPVSVMTILYCLIYKET 215

  Fly   324 YDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIK 388
                                                   |:..|...||.|..:..:|
Zfish   216 ---------------------------------------ERRTKDLAELQGINSSTNS------- 234

  Fly   389 RLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSV 453
                ||.|.|..:.:                                        .|.....|:.
Zfish   235 ----SGDAQPQKIRS----------------------------------------CFGCKHVSNT 255

  Fly   454 NQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHN 518
            ::.|                         ||..|.....|....||..|.
Zfish   256 SRTQ-------------------------ALSHTNAAKTLDDQLTNFNSY--------------- 280

  Fly   519 QSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPP 583
                  |.|:||.||    .|.|:                    ||
Zfish   281 ------ASSEEEDRS----GNFQE--------------------SC------------------- 296

  Fly   584 TLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELAL 648
                                                                             
Zfish   297 ----------------------------------------------------------------- 296

  Fly   649 TYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTP 713
                                                                             
Zfish   297 ----------------------------------------------------------------- 296

  Fly   714 SQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPG 778
                            .|.:::|:|.||               |:|              ...|.
Zfish   297 ----------------RHQENKSESYEE---------------ENF--------------FPTPV 316

  Fly   779 KLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEER 843
            |          :||  |.:|..:.|. ..|..:||
Zfish   317 K----------ASP--TKTKKCVSYK-FKPKDVSP------------------------------ 338

  Fly   844 ETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHS 908
             ..::|.:..|..|..:|:                            |...|.|.:||.:....:
Zfish   339 -LKNTNGDAKPGASSFSSA----------------------------ESVNAPSSSSSSKPIDGT 374

  Fly   909 IGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPC 973
            :......:|.:.||             :.:||.:|:|.||..|:..||||:::.|:..||  ..|
Zfish   375 LKCQITKRKRMVLI-------------KEKKAAQTLSAILLAFILTWTPYNIMVLISTFC--SDC 424

  Fly   974 INEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            |...|:...|:|||.||.:||.||||.|:.|:|||..:|
Zfish   425 IPLSLWHLGYWLCYVNSTVNPMCYALCNKTFQKTFRMLL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	66/190 (35%)
		7tm_4	150..>336	CDD:304433	66/185 (36%)
chrm5a	NP_001018639.1	7tm_4	34..>167	CDD:304433	52/132 (39%)
		7tm_1	42..448	CDD:278431	150/846 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920