Protein Alignment mAChR-B and Chrm5

DIOPT Version :9

• Sequence 1: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_059058.1
• Gene: Chrm5 / 53949
• RGDID: 620027
• Length: 531
• Species: Rattus norvegicus
• Alignment Length: 912
• Identity: 189/912 - (20%)
• Similarity: 296/912 - (32%)
• Gaps: 413/912 - (45%)

  Fly   111 MSGSS-SDSEILG-PV----LPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSN 169
            |.|.| ::|.:.| ||    |....||:.|.||:..|:..::|:.||:||:::|.|:..::..:|
  Rat     1 MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNN 65

  Fly   170 YFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCS 234
            |::.|||..|::||..||..||.|:|.|.|.||.:.|||||::||.....|...:|:|:.|||.|
  Rat    66 YYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFS 130

  Fly   235 VKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTA 299
            :.....||:.||..|...|:.:.|::..:|:..:|..|::..|||.:.|.:|.:|||.:|.....
  Rat   131 ITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFG 195

  Fly   300 LIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEK 364
            ..|..::..:.|:.:||..||:
  Rat   196 TAIAAFYIPVSVMTILYCRIYR------------------------------------------- 217

  Fly   365 ILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKRE 429
                                                    |.||.|.:......:....||||||
  Rat   218 ----------------------------------------ETEKRTKDLADLQGSDSVAEAKKRE 242

  Fly   430 AAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQ 494
            .|      :|:...:|.|....|:.|.::  .|...::.|:.:|             |.||
  Rat   243 PA------QRTLLRSFFSCPRPSLAQRER--NQASWSSSRRSTS-------------TTGK---- 282

  Fly   495 KSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRP 559
              ||.:..:.|               ..::|:
  Rat   283 --TTQATDLSA---------------DWEKAE--------------------------------- 297

  Fly   560 KRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQC 624
            :.|:||:.....:       .|.||                   :|.|.|.:.::     :|.:.
  Rat   298 QVTTCSSYPSSED-------EAKPT-------------------TDPVFQMVYKS-----EAKES 331

  Fly   625 PTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPV 689
            |            |..|...|...|                      ..|:.|..:|
  Rat   332 P------------GKESNTQETKET----------------------VVNTRTENSD-------- 354

  Fly   690 LPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYT 754
                                ..||....||:.:         ::.:||   :.||.:.||:|...
  Rat   355 --------------------YDTPKYFLSPAAA---------HRLKSQ---KCVAYKFRLVVKAD 387

  Fly   755 GIED----FAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKV 815
            |.::    ..||:...|                      |.|:   |||
  Rat   388 GTQETNNGCRKVKIMPC----------------------SFPV---SKD---------------- 411

  Fly   816 KTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKK 880
                                                  |||.|
  Rat   412 --------------------------------------PSTKG---------------------- 416

  Fly   881 NAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTIS 945
                .|.|       .|...:||             |.:.|:             :.|||.:|:|
  Rat   417 ----PDPN-------LSHQMTKR-------------KRMVLV-------------KERKAAQTLS 444

  Fly   946 FILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTR 1010
            .||..|:..||||:::.||..||  ..|:...|:...|:|||.||.:||.||||.|:.|:|||..
  Rat   445 AILLAFIITWTPYNIMVLVSTFC--DKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKL 507

  Fly  1011 IL 1012
            :|
  Rat   508 LL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	63/190 (33%)
		7tm_4	150..>336	CDD:304433	63/185 (34%)
Chrm5	NP_059058.1	7tm_4	39..>166	CDD:304433	47/126 (37%)
		7tm_1	46..255	CDD:278431	76/297 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..295		11/71 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..346		6/52 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920