DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-B and TyrRII

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001262682.1	Gene:	TyrRII / 42135	FlyBaseID:	FBgn0038541	Length:	586	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	116/536 - (21%)
Similarity:	200/536 - (37%)	Gaps:	154/536 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 NTN----LLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFAL---W-QTILIAICLAICIILTVG 149
            |:|    .||.::..::.||..|:..:...::..|.:..:.:   | :::.:|:.|.| |::||.
  Fly    27 NSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVI-ILVTVV 90

  Fly   150 GNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDY 214
            ||.||:||.:..|.:|..:|.|:.:||.||.|:||..||...:..:.|.|..|.:|||:|:|:|.
  Fly    91 GNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDI 155

  Fly   215 TVCLVSQYTVLLITIDRYCSVKIAAKY-RSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGK 278
            .:|..|..::..|::|||.:|.....| :..|::...:.|:.:.||....:......|| :..|:
  Fly   156 LLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGW-YEVGR 219

  Fly   279 RDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVAL 343
            .......|.....|..:..:|:  |.::..|.|:..:|.   |..|.:..|.:...|...|
  Fly   220 HQAEFVDCRYNQNKGYVVFSAM--GSFFIPLTVMLYVYV---KIGYVLTSRRQRIVRDAYS---- 275

  Fly   344 SAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSA---CTTVIKRLSGSGQANPLAVATEE 405
                               |:.....|:  ||....:|.   ||..
  Fly   276 -------------------ERTADYDVD--GDNFISESEHYHCTPT------------------- 300

  Fly   406 VEKMTPEQRR----------ASAAKIQEEAKKREAAVDAEKSERSSS------------------ 442
              |..|.::.          ..:|.....||..:::|...|..:.||
  Fly   301 --KWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTL 363

  Fly   443 -----PAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVF---------------GAQAALLAT 487
                 |.|           .:|:...:|:::...|:|...:               |.:|:...|
  Fly   364 TFKHQPTF-----------YELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDT 417

  Fly   488 RGKGNLQKSTT----------NSKSIEAMHQYHHHQQ-----HHHNQSPLQRAQSKEEMRSLHHH 537
            ...||:..:||          .::.:||..:....||     |||..:              |||
  Fly   418 CLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHA--------------HHH 468

  Fly   538 -QNQQQPHHQHHQNQP 552
             .:.||.||.||...|
  Fly   469 GSHGQQSHHNHHHRMP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	55/191 (29%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	53/186 (28%)
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	45/130 (35%)
TyrRII	NP_001262682.1	7tm_1	91..>277	CDD:278431	55/214 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460692
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840