Protein Alignment mAChR-B and 5-HT2A

DIOPT Version :9

• Sequence 1: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Alignment Length: 985
• Identity: 163/985 - (16%)
• Similarity: 286/985 - (29%)
• Gaps: 422/985 - (42%)

  Fly    90 DVNNTNLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTIL--------IAICLAICIIL 146
            :|.||:|.:.:.|.:: ..:|.:.|::|      :...||:.::.|        ......:..|.
  Fly   240 NVTNTSLDMFLPNLTA-LNTTSTASTAD------MATEFAVTKSFLDYSPHGYDFLFLFVVFFIF 297

  Fly   147 TVG-GNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWL 210
            ..| |||||.||..:||.::..:|||:.|||..|:|:....||...|....|||.||...|::::
  Fly   298 AGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYV 362

  Fly   211 SVDYTVCLVSQYTVLLITIDRYCSVK--IAAKYRSWRTRTRVIYMVTITWIIPALL-FFISIFGW 272
            :.|...|..|...:..|::.||..::  :.:::||.:..|.:  .:.|.|::..:: ..|::.|
  Fly   363 TCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGI--KIAIVWVMAMMVSSSITVLG- 424

  Fly   273 EHFTGKRDLL--PGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQR 335
              ...:::::  |..|.:.       |.|..:   :.:|:..::
  Fly   425 --LVNEKNIMPEPNICVIN-------NRAFFV---FGSLVAFYI--------------------- 456

  Fly   336 KMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLA 400
            .|..||...|               :...:|:.|...|.:..:     :.:.:||.|.....|
  Fly   457 PMLMMVTTYA---------------LTIPLLRKKARFAAEHPE-----SELFRRLGGRFTLRP-- 499

  Fly   401 VATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKS-------ERSSSPAFDSDEESSVNQAQQ 458
                    ...:|:....:.......|..:..|..::       |...:|:    ..|.|..|::
  Fly   500 --------QHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPS----RRSGVEPAER 552

  Fly   459 LITQQKLNNMRKRSSI---GLVFGAQAALLATRGKGNLQKSTTNSK---SIEAMHQYHHHQQHHH 517
            .:.||:..:.|...::   .:|.|...|    .|.|.....|.:|.   |...:.:       |.
  Fly   553 PLMQQRTASSRSMGTVSFRNVVNGTSGA----AGSGRRTTGTAHSSFRFSGAGIFR-------HS 606

  Fly   518 NQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAP 582
            :.||.....|....||        ....:.|...||            .:.::|.|.||
  Fly   607 SSSPASSCHSTSTSRS--------SSFWRKHGGYPN------------LMDRLAIHLRL------ 645

  Fly   583 PTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELA 647
                                       .||
  Fly   646 ---------------------------SLV----------------------------------- 648

  Fly   648 LTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQT 712
                                                                ||.|:
  Fly   649 ----------------------------------------------------PPSSH-------- 653

  Fly   713 PSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVP 777
                                                                             
  Fly   654 ----------------------------------------------------------------- 653

  Fly   778 GKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEE 842
                   |:|||                      |.:|..|.||.|.|.:..|
  Fly   654 -------PNRRA----------------------SVRVTISQPQLGYPTNVGG------------ 677

  Fly   843 RETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKN-----------------------AGD 884
                         ..|.|.....||.||.....|.|..:                       ||.
  Fly   678 -------------NGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGG 729

  Fly   885 DDANREEKSLAASRNSSKRAFIHSIGKHFK---SKKALPLI----LGVGGRQKSKSENRA---RK 939
            :...::.|..|......:|..:    :.||   ::.|.|.:    |....::.|.|.|..   :|
  Fly   730 NHMVQKVKPTALKPEEPQRNKV----RPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQK 790

  Fly   940 AFRTISFILGCFVACWTPYHVLALVEGFCRHPPC-INEHLYMFSYFLCYANSPMNPFCYALANQQ 1003
            |.:.:..:...||.||:|:.:|.::...|  |.| :.||:.....:|.|.:|.:||..|.:.|:.
  Fly   791 ATKVLGLVFFTFVLCWSPFFILNIIFAAC--PECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRT 853

  Fly  1004 FKKTFTRILK 1013
            |:..|.|:||
  Fly   854 FRAAFIRLLK 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	45/195 (23%)
		7tm_4	150..>336	CDD:304433	44/190 (23%)
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	40/133 (30%)
		7tm_1	302..>477	CDD:278431	50/225 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010