DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-B and GPR153

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_997253.2	Gene:	GPR153 / 387509	HGNCID:	23618	Length:	609	Species:	Homo sapiens

Alignment Length:	827	Identity:	154/827 - (18%)
Similarity:	263/827 - (31%)	Gaps:	290/827 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 AICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGY--- 198
            |:...:|..|::..|...:|:....:...:|..:.:.:||||.||...|.:..|::..|:..
Human    11 AVGWLVCGGLSLLANAWGILSVGAKQKKWKPLEFLLCTLAATHMLNVAVPIATYSVVQLRRQRPD 75

  Fly   199 --WDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIP 261
              |:.|  ||.:::|..||:.|.:.::|..::..|...|.....||....:.:.::.|...|::.
Human    76 FEWNEG--LCKVFVSTFYTLTLATCFSVTSLSYHRMWMVCWPVNYRLSNAKKQAVHTVMGIWMVS 138

  Fly   262 ALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFV---LYAGIYKTA 323
            .:|..:...|| |.|.:|....| |  :|:       ...||..:....:|.|   :..|:..||
Human   139 FILSALPAVGW-HDTSERFYTHG-C--RFI-------VAEIGLGFGVCFLLLVGGSVAMGVICTA 192

  Fly   324 YDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQ---TDLDSA--C 383
            ..:          .|:: |:..|..:..........|:|:...|.:..:.|.:   |.|.:.  .
Human   193 IAL----------FQTL-AVQVGRQADRRAFTVPTIVVEDAQGKRRSSIDGSEPAKTSLQTTGLV 246

  Fly   384 TTVI------------------KRLSGSGQANPLAVATEEVEK--MTP------EQRRASAAKIQ 422
            ||::                  .|...|.....|.|....|.:  :.|      ::.||....::
Human   247 TTIVFIYDCLMGFPVLVVSFSSLRADASAPWMALCVLWCSVAQALLLPVFLWACDRYRADLKAVR 311

  Fly   423 EEAKKREAAVDAEKSERSSSPAFDSDEESSVNQ--AQQLITQQKLNNMRKRSSIGLVFGAQAALL 485
            |:.    .|:.|...|        ||:|:|:..  :..|:.::.|:           :|.....:
Human   312 EKC----MALMANDEE--------SDDETSLEGGISPDLVLERSLD-----------YGYGGDFV 353

  Fly   486 ATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQN 550
            |                ::.|.:|                    |:.:|.....|..|.
Human   354 A----------------LDRMAKY--------------------EISALEGGLPQLYPL------ 376

  Fly   551 QPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLL---NTSDPLSPVDLAPIEVP---SDQVHQ 609
                   ||           .:.|::..|..|||..   :.:|..:.|.| |..:|   |.:...
Human   377 -------RP-----------LQEDKMQYLQVPPTRRFSHDDADVWAAVPL-PAFLPRWGSGEDLA 422

  Fly   610 GLVQTILPP-PDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTA 673
            .|...:||. |:..:.                   |.||...|...:...|...||...|
Human   423 ALAHLVLPAGPERRRA-------------------SLLAFAEDAPPSRARRRSAESLLSL----- 463

  Fly   674 NSTTSPNDSVQGKPPVLPP-PPPARRNPPKSNLNQSLSQTPSQNQSPS-QSLSLNLNPNHNQSQS 736
                        :|..|.. |..||.:||.|         |.:...|. :|.|.:|.|
Human   464 ------------RPSALDSGPRGARDSPPGS---------PRRRPGPGPRSASASLLP------- 500

  Fly   737 QSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAI 801
                :|.|:                                  .|.:|             :...
Human   501 ----DAFAL----------------------------------TAFEC-------------EPQA 514

  Fly   802 LYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIE-ERETSDSNTNKM-PSTSGTTSSTG 864
            |..|..|.|.:|    :.|....|..|.  |||...:|.. .|.::.|:...: |..|.:....|
Human   515 LRRPPGPFPAAP----AAPDGADPGEAP--TPPSSAQRSPGPRPSAHSHAGSLRPGLSASWGEPG 573

  Fly   865 GV---GGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHS 908
            |:   ||||.....                  |::...||..|.:||
Human   574 GLRAAGGGGSTSSF------------------LSSPSESSGYATLHS 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	44/198 (22%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	43/193 (22%)
GPR153	NP_997253.2	7tm_1	29..>219	CDD:278431	45/213 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..496		16/75 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..609		28/113 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8273
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860