Protein Alignment mAChR-B and Dop2R

DIOPT Version :9

• Sequence 1: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Alignment Length: 963
• Identity: 185/963 - (19%)
• Similarity: 304/963 - (31%)
• Gaps: 425/963 - (44%)

  Fly   108 GSTMSGSSS-----------------DSEILGPVLPPFAL-----------------------WQ 132
            |||:||:|:                 :..:.|..|..:.|                       |.
  Fly   315 GSTVSGTSTIAPGVAITGSRGSGLLLEQNLTGLYLDGYRLNCTNETLNLTDSCGELRVVDHNYWA 379

  Fly   133 TILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKG 197
            .|||     :..|||:.|||||:|:...:|:::..:||||.|||..|:|:..|.|||...:::.|
  Fly   380 LILI-----LFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNG 439

  Fly   198 YWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPA 262
            .|.|..::||.::::|......|.:.::.|:||||.:|....||...:...||...:.:.|.|.|
  Fly   440 AWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISA 504

  Fly   263 LLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALII-----GYYWTTLIVLFVLYAGIYKT 322
            .:....:.|..: |..|:  |..||       .:|...|:     .:|...:|::| ||..|:|.
  Fly   505 AIGSPIVLGLNN-TPNRE--PDVCA-------FYNADFILYSSLSSFYIPCIIMVF-LYWNIFKA 558

  Fly   323 AYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVI 387
            .     ||.|::::     |.....:|.:.|     |.:.|.|.:|: .||  :|.|||:
  Fly   559 L-----RSRARKQR-----AARKPHLSELTG-----GSVIENIAQTR-RLA--ETALDSS----- 600

  Fly   388 KRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESS 452
                                      |.||.....|.|....:..:.|:.|.:.||  |.|:...
  Fly   601 --------------------------RHASRILPDEAATNTASGSNEEEDENAISP--DIDDCHV 637

  Fly   453 VNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHH 517
            :                                            .|.||.|.|
  Fly   638 I--------------------------------------------VNDKSTEFM----------- 647

  Fly   518 NQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAP 582
                  .|...||                               |..|.::||....:||
  Fly   648 ------LATVVEE-------------------------------TGNSVVAQITTQPQLV----- 670

  Fly   583 PTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELA 647
                                                         ::|...:...|.::.|
  Fly   671 ---------------------------------------------VADPNGNHDSGYAASN---- 686

  Fly   648 LTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPA--RRNPPKSNLNQSLS 710
                         :|:..|.:|..:|::.||......|.||..|.|..|  :|:...|....:..
  Fly   687 -------------VDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGD 738

  Fly   711 QTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLD 775
            .:|.:.:...:|:.::             ..:||::....|.|
  Fly   739 DSPKRGEPALRSVGVD-------------NSSVAMKPLSFVRY---------------------- 768

  Fly   776 VPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERI 840
                                                                  ||...:.|.|.
  Fly   769 ------------------------------------------------------GVQEAMTLARN 779

  Fly   841 EERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAF 905
            :             ||..|||.|                      .:.:::|:..|||.:
  Fly   780 D-------------STLSTTSKT----------------------SSRKDKKNSQASRFT----- 804

  Fly   906 IHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRH 970
            |:.:.|..|.|           |:|| |..:.|||.:|::.:||.|:.||.|:....:::..|..
  Fly   805 IYKVHKASKKK-----------REKS-SAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAK 857

  Fly   971 -----PPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRILKGDLHM 1018
                 .|.:.  .||.:.:|.|.||.:||..|.:.|.:|:|.|.:|    :||
  Fly   858 FKKDCRPGLT--AYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKI----MHM 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	58/195 (30%)
		7tm_4	150..>336	CDD:304433	58/190 (31%)
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	65/209 (31%)
		TM helix 1	377..403	CDD:320181	13/30 (43%)
		TM helix 2	410..436	CDD:320181	13/25 (52%)
		TM helix 3	448..478	CDD:320181	9/29 (31%)
		TM helix 4	490..513	CDD:320181	5/22 (23%)
		TM helix 5	529..558	CDD:320181	8/29 (28%)
		7tm_GPCRs	<822..898	CDD:333717	24/77 (31%)
		TM helix 6	825..850	CDD:320095	10/24 (42%)
		TM helix 7	866..891	CDD:320095	9/26 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840