DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mAChR-B and HRH1

DIOPT Version :9

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:NP_000852.1 Gene:HRH1 / 3269 HGNCID:5182 Length:487 Species:Homo sapiens


Alignment Length:925 Identity:175/925 - (18%)
Similarity:256/925 - (27%) Gaps:451/925 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 NTNLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLA 157
            |::.||  .::..:|..|...|        |.|.|       |:.:...||:: |||.|:|||.|
Human     5 NSSCLL--EDKMCEGNKTTMAS--------PQLMP-------LVVVLSTICLV-TVGLNLLVLYA 51

  Fly   158 FIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQY 222
            ...:|.:....|.:|.||:..|:::|.|.||...:|:|...|.||..||..|||:||.....|.:
Human    52 VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIF 116

  Fly   223 TVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDL-LPGQC 286
            :|.::.||||.||:...:|..:||:||....:...|.: :.|:.|.|.||.||..:..: ...:|
Human   117 SVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFL-SFLWVIPILGWNHFMQQTSVRREDKC 180

  Fly   287 AVQFLKDPIFNT-ALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSG 350
            ...|.....|.. ..||.:|..||::|: .||.|||......:..|...|.:.|...:       
Human   181 ETDFYDVTWFKVMTAIINFYLPTLLMLW-FYAKIYKAVRQHCQHRELINRSLPSFSEI------- 237

  Fly   351 MAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRR 415
                                                                     |:.||..:
Human   238 ---------------------------------------------------------KLRPENPK 245

  Fly   416 ASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGA 480
            ..|.|                                                            
Human   246 GDAKK------------------------------------------------------------ 250

  Fly   481 QAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHH 545
                   .||                            :||.:..:.|                 
Human   251 -------PGK----------------------------ESPWEVLKRK----------------- 263

  Fly   546 QHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQG 610
                                                                             
Human   264 ----------------------------------------------------------------- 263

  Fly   611 LVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANS 675
                   |.||                   .|.|.|                             
Human   264 -------PKDA-------------------GGGSVL----------------------------- 273

  Fly   676 TTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSP---SQSLSLNLNPNHNQSQSQ 737
                                           :|.||||.:.:||   ||                
Human   274 -------------------------------KSPSQTPKEMKSPVVFSQ---------------- 291

  Fly   738 SIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAIL 802
                               ||..:|.:..|            ...|..|.:|::  |.||:|.: 
Human   292 -------------------EDDREVDKLYC------------FPLDIVHMQAAA--EGSSRDYV- 322

  Fly   803 YSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVG 867
                       .|..|..|..|.:.  |:......|..|::...||.:.....:..||.:..|.|
Human   323 -----------AVNRSHGQLKTDEQ--GLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKG 374

  Fly   868 GGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSK 932
                       |..:|.:......|.......|..|.::.  |.|.                   
Human   375 -----------KLRSGSNTGLDYIKFTWKRLRSHSRQYVS--GLHM------------------- 407

  Fly   933 SENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCY 997
              ||.|||.:.:.||:..|:.||.||.:..:|..||::  |.||||:||:.:|.|.||.:||..|
Human   408 --NRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKN--CCNEHLHMFTIWLGYINSTLNPLIY 468

  Fly   998 ALANQQFKKTFTRIL 1012
            .|.|:.|||||.|||
Human   469 PLCNENFKKTFKRIL 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tm_1 150..>341 CDD:278431 65/192 (34%)
7tm_4 150..>336 CDD:304433 63/187 (34%)
HRH1NP_000852.1 7tmA_Histamine_H1R 28..479 CDD:320178 162/886 (18%)
TM helix 1 30..54 CDD:320178 11/24 (46%)
TM helix 2 63..85 CDD:320178 9/21 (43%)
TM helix 3 101..123 CDD:320178 7/21 (33%)
Important for agonist binding 107..112 2/4 (50%)
TM helix 4 146..162 CDD:320178 3/16 (19%)
TM helix 5 188..211 CDD:320178 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..291 23/315 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..379 9/44 (20%)
TM helix 6 414..436 CDD:320178 7/21 (33%)
Important for agonist binding 424..428 1/3 (33%)
TM helix 7 447..472 CDD:320178 13/24 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1245472at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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