DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-B and ser-6

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_741350.1	Gene:	ser-6 / 259560	WormBaseID:	WBGene00021897	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	327	Identity:	75/327 - (22%)
Similarity:	132/327 - (40%)	Gaps:	74/327 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 ILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGY 198
            ||:::.|.:.....|.||:||....:..::::..:|:.:.||..:|:|:|.:.:||..|......
Worm     2 ILLSLTLGVVNCFVVIGNLLVFYVILTKKSLQTSTNHLVLSLTISDLLLGILILPFAIIQEHSNE 66

  Fly   199 WDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVT-ITWIIPA 262
            |..|...|.||||||..:...|.|.:|.|:.|||.:|:...|| ...:.|:|:.::| :.|....
Worm    67 WIFGHFGCRLWLSVDVFLSTASIYNLLAISFDRYMAVRQPIKY-PIISSTKVVRLMTFLVWFCSL 130

  Fly   263 LLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQ 327
            ||                                            .::||||   :...|:|.:
Worm   131 LL--------------------------------------------AVILFVL---LTLNAHDSE 148

  Fly   328 KRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSG 392
            ...:.:...:.||..:.: ||:.....|..:.::..:|.         ||.|.::.|..:|..:|
Worm   149 PTKDCQPTSLPSMYIIFS-AMASFIVPAFVMVILNVRIF---------QTVLHTSRTMTVKSKNG 203

  Fly   393 SGQANPLAVATEEVEKMTPEQRRASAAKIQEE--AKKREAAVD-------AEKSERSS---SPAF 445
            |.:.:........|:|....:.|.|.   :||  ....:..:|       .||..:||   :||.
Worm   204 SLRVHRRKEPIIPVKKHDKYETRLSH---EEECVGSPSKEVIDPIPVVAVVEKHHKSSAVDAPAI 265

  Fly   446 DS 447
            .|
Worm   266 RS 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	45/191 (24%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	44/186 (24%)
ser-6	NP_741350.1	7tmA_amine_R-like	3..391	CDD:320098	74/326 (23%)
		TM helix 1	4..28	CDD:320098	6/23 (26%)
		TM helix 2	37..59	CDD:320098	8/21 (38%)
		TM helix 3	75..97	CDD:320098	10/21 (48%)
		TM helix 4	120..136	CDD:320098	4/59 (7%)
		TM helix 5	159..183	CDD:320098	5/24 (21%)
		TM helix 6	318..343	CDD:320098
		TM helix 7	359..384	CDD:320098
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870