DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and Chrm1

DIOPT Version :9

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:NP_542951.1 Gene:Chrm1 / 25229 RGDID:2342 Length:460 Species:Rattus norvegicus


Alignment Length:925 Identity:173/925 - (18%)
Similarity:255/925 - (27%) Gaps:499/925 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 SSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATD 179
            |.:..:|.|...|   ||...|.|...:..:.||.||:|||::|.|:..::..:|||:.|||..|
  Rat    10 SPNITVLAPGKGP---WQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACAD 71

  Fly   180 MLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSW 244
            ::|||.||..||.|:|.|:|.||.:.|||||::||.....|...:|||:.|||.||.....||:.
  Rat    72 LIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAK 136

  Fly   245 RTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTL 309
            ||..|...|:.:.|::..:|:..:|..|::..|:|.:|.|||.:|||..||......:..::..:
  Rat   137 RTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPV 201

  Fly   310 IVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAG 374
            .|:..||..||:                                                     
  Rat   202 TVMCTLYWRIYR----------------------------------------------------- 213

  Fly   375 DQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSER 439
                                          |.|                                
  Rat   214 ------------------------------ETE-------------------------------- 216

  Fly   440 SSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIE 504
                          |:|::|...|               |::     |.|||             
  Rat   217 --------------NRARELAALQ---------------GSE-----TPGKG------------- 234

  Fly   505 AMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQ 569
                                                                             
  Rat   235 ----------------------------------------------------------------- 234

  Fly   570 IAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSD 634
                                                                             
  Rat   235 ----------------------------------------------------------------- 234

  Fly   635 RPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPAR-- 697
               |.||.:||.:                                ....:|.    |..||.|  
  Rat   235 ---GGSSSSSERS--------------------------------QPGAEGS----PESPPGRCC 260

  Fly   698 ---RNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDF 759
               |.|                                               |||.:|:..|: 
  Rat   261 RCCRAP-----------------------------------------------RLLQAYSWKEE- 277

  Fly   760 AKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGT 824
             :...|..:|::                 .||..|....:.::..||         ..|..|..|
  Rat   278 -EEEDEGSMESL-----------------TSSEGEEPGSEVVIKMPM---------VDSEAQAPT 315

  Fly   825 PQSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANR 889
            .|      ||          .|..||.|.|:..|...     ||.|::.               |
  Rat   316 KQ------PP----------KSSPNTVKRPTKKGRDR-----GGKGQKP---------------R 344

  Fly   890 EEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVAC 954
            .::.||                                ::|:.|..:.:||.||:|.||..|:..
  Rat   345 GKEQLA--------------------------------KRKTFSLVKEKKAARTLSAILLAFILT 377

  Fly   955 WTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL------- 1012
            ||||:::.||..||:  .|:.|.|:...|:|||.||.:||.||||.|:.|:.||..:|       
  Rat   378 WTPYNIMVLVSTFCK--DCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKR 440

  Fly  1013 --------KGDLHMT 1019
                    .|.:|.|
  Rat   441 RWRKIPKRPGSVHRT 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tm_1 150..>341 CDD:278431 69/190 (36%)
7tm_4 150..>336 CDD:304433 69/185 (37%)
Chrm1NP_542951.1 7tmA_mAChR_M1 26..429 CDD:341356 161/878 (18%)
TM helix 1 28..52 CDD:341356 10/23 (43%)
TM helix 2 61..83 CDD:341356 12/21 (57%)
TM helix 3 99..121 CDD:341356 10/21 (48%)
TM helix 4 144..160 CDD:341356 3/15 (20%)
TM helix 5 186..209 CDD:341356 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..257 14/233 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..297 6/41 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..351 17/108 (16%)
TM helix 6 364..386 CDD:341356 10/21 (48%)
TM helix 7 397..422 CDD:341356 14/24 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1245472at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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