DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and Chrm4

DIOPT Version :10

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:NP_113735.1 Gene:Chrm4 / 25111 RGDID:2344 Length:478 Species:Rattus norvegicus


Alignment Length:881 Identity:179/881 - (20%)
Similarity:257/881 - (29%) Gaps:443/881 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 QTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLK 196
            :.:.||.......::||.|||||:|:..|:|.::..:|||:.|||..|::||..||..||:|::|
  Rat    30 EMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTLYIIK 94

  Fly   197 GYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIP 261
            |||.||.::|||||::||.|...|...:|:|:.|||..|.....|.:.||......|:...|::.
  Rat    95 GYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLS 159

  Fly   262 ALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDM 326
            .:|:..:|..|:...|||.:...||.:|||.:|.......|..::..::::.|||..|     .:
  Rat   160 FVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHI-----SL 219

  Fly   327 QKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLS 391
            ..||                                                             
  Rat   220 ASRS------------------------------------------------------------- 223

  Fly   392 GSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQA 456
                         .|.|..||                     ..|.:::.:.||           
  Rat   224 -------------RVHKHRPE---------------------GPKEKKAKTLAF----------- 243

  Fly   457 QQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSP 521
                                                 .||.....||               :.|
  Rat   244 -------------------------------------LKSPLMKPSI---------------KKP 256

  Fly   522 LQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLL 586
            .....|:||:|                    |..|:                      .|||   
  Rat   257 PPGGASREELR--------------------NGKLE----------------------EAPP--- 276

  Fly   587 NTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYD 651
                            |:           ||||     |.|:.|  .|....:|||::       
  Rat   277 ----------------PA-----------LPPP-----PRPVPD--KDTSNESSSGSA------- 300

  Fly   652 LMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQN 716
             ..|::.|...|.|      ||.:||          |.||.|....|                  
  Rat   301 -TQNTKERPPTELS------TAEATT----------PALPAPTLQPR------------------ 330

  Fly   717 QSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLA 781
                     .|||....|:.|           ::...||.|         |:.||.::       
  Rat   331 ---------TLNPASKWSKIQ-----------IVTKQTGNE---------CVTAIEIV------- 359

  Fly   782 ADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETS 846
                                                       |.:.||:.|.            
  Rat   360 -------------------------------------------PATPAGMRPA------------ 369

  Fly   847 DSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGK 911
                                                    ||...|..:.:||..          
  Rat   370 ----------------------------------------ANVARKFASIARNQV---------- 384

  Fly   912 HFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINE 976
                            |:|.:...|.||..|||..||..|:..||||:|:.||..||:  .||.|
  Rat   385 ----------------RKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQ--SCIPE 431

  Fly   977 HLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            .::...|:|||.||.:||.||||.|..|||||..:|
  Rat   432 RVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 67/175 (38%)
TM helix 2 168..194 CDD:320429 13/25 (52%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 4/22 (18%)
TM helix 5 293..322 CDD:320429 6/28 (21%)
7tm_GPCRs <932..1008 CDD:475119 37/75 (49%)
TM helix 6 941..963 CDD:410628 11/21 (52%)
TM helix 7 976..1001 CDD:410628 13/24 (54%)
Chrm4NP_113735.1 7tmA_mAChR_M4 32..463 CDD:341344 176/873 (20%)
TM helix 1 33..59 CDD:341344 10/25 (40%)
TM helix 2 66..92 CDD:341344 13/25 (52%)
TM helix 3 104..134 CDD:341344 14/29 (48%)
TM helix 4 146..169 CDD:341344 4/22 (18%)
TM helix 5 191..220 CDD:341344 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 271..333 29/171 (17%)
TM helix 6 392..422 CDD:341344 15/29 (52%)
TM helix 7 431..456 CDD:341344 13/24 (54%)

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