DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-B and Chrm4

DIOPT Version :9

Sequence 1:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_113735.1	Gene:	Chrm4 / 25111	RGDID:	2344	Length:	478	Species:	Rattus norvegicus

Alignment Length:	881	Identity:	179/881 - (20%)
Similarity:	257/881 - (29%)	Gaps:	443/881 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 QTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLK 196
            :.:.||.......::||.|||||:|:..|:|.::..:|||:.|||..|::||..||..||:|::|
  Rat    30 EMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTLYIIK 94

  Fly   197 GYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIP 261
            |||.||.::|||||::||.|...|...:|:|:.|||..|.....|.:.||......|:...|::.
  Rat    95 GYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLS 159

  Fly   262 ALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDM 326
            .:|:..:|..|:...|||.:...||.:|||.:|.......|..::..::::.|||..|     .:
  Rat   160 FVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHI-----SL 219

  Fly   327 QKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLS 391
            ..||
  Rat   220 ASRS------------------------------------------------------------- 223

  Fly   392 GSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQA 456
                         .|.|..||                     ..|.:::.:.||
  Rat   224 -------------RVHKHRPE---------------------GPKEKKAKTLAF----------- 243

  Fly   457 QQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSP 521
                                                 .||.....||               :.|
  Rat   244 -------------------------------------LKSPLMKPSI---------------KKP 256

  Fly   522 LQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLL 586
            .....|:||:|                    |..|:                      .|||
  Rat   257 PPGGASREELR--------------------NGKLE----------------------EAPP--- 276

  Fly   587 NTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYD 651
                            |:           ||||     |.|:.|  .|....:|||::
  Rat   277 ----------------PA-----------LPPP-----PRPVPD--KDTSNESSSGSA------- 300

  Fly   652 LMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQN 716
             ..|::.|...|.|      ||.:||          |.||.|....|
  Rat   301 -TQNTKERPPTELS------TAEATT----------PALPAPTLQPR------------------ 330

  Fly   717 QSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLA 781
                     .|||....|:.|           ::...||.|         |:.||.::
  Rat   331 ---------TLNPASKWSKIQ-----------IVTKQTGNE---------CVTAIEIV------- 359

  Fly   782 ADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEERETS 846
                                                       |.:.||:.|.
  Rat   360 -------------------------------------------PATPAGMRPA------------ 369

  Fly   847 DSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGK 911
                                                    ||...|..:.:||..
  Rat   370 ----------------------------------------ANVARKFASIARNQV---------- 384

  Fly   912 HFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINE 976
                            |:|.:...|.||..|||..||..|:..||||:|:.||..||:  .||.|
  Rat   385 ----------------RKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQ--SCIPE 431

  Fly   977 HLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            .::...|:|||.||.:||.||||.|..|||||..:|
  Rat   432 RVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	67/190 (35%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	67/185 (36%)
Chrm4	NP_113735.1	7tmA_mAChR_M4	32..463	CDD:341344	176/873 (20%)
		TM helix 1	34..58	CDD:341344	10/23 (43%)
		TM helix 2	67..89	CDD:341344	11/21 (52%)
		TM helix 3	105..127	CDD:341344	10/21 (48%)
		TM helix 4	150..166	CDD:341344	3/15 (20%)
		TM helix 5	192..215	CDD:341344	4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..333		37/228 (16%)
		TM helix 6	398..420	CDD:341344	11/21 (52%)
		TM helix 7	431..456	CDD:341344	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920