DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-B and Chrm2

DIOPT Version :10

Sequence 1:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster
Sequence 2:NP_987076.2 Gene:Chrm2 / 243764 MGIID:88397 Length:466 Species:Mus musculus


Alignment Length:902 Identity:164/902 - (18%)
Similarity:257/902 - (28%) Gaps:447/902 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 MSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASL 175
            |:.|::.|.....:..|:..::.:.|.:......::|:.|||||:::..|:|:::..:|||:.||
Mouse     1 MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSL 65

  Fly   176 AATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAK 240
            |..|::||..||..||:|.:.|||.|||::|||||::||.|...|...:|:|:.|||..|.....
Mouse    66 ACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLT 130

  Fly   241 YRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYY 305
            |...||......|:...|::..:|:..:|..|:...|.|.:..|:|.:||..:........|..:
Mouse   131 YPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAF 195

  Fly   306 WTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKV 370
            :..:|::.|||..|                                                   
Mouse   196 YLPVIIMTVLYWHI--------------------------------------------------- 209

  Fly   371 ELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAE 435
                                                       .|||.::|::|.|:        
Mouse   210 -------------------------------------------SRASKSRIKKEKKE-------- 223

  Fly   436 KSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNS 500
                   |..:.|..|. :..|..|.:...|||                  ..|.|.|       
Mouse   224 -------PVANQDPVSP-SLVQGRIVKPNNNNM------------------PGGDGGL------- 255

  Fly   501 KSIEAMHQYHHHQQHHHNQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCS 565
                                                                             
Mouse   256 ----------------------------------------------------------------- 255

  Fly   566 TLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSD 630
                  ||:::.:..||                                                
Mouse   256 ------EHNKIQNGKAP------------------------------------------------ 266

  Fly   631 DYSDRPFGNSSGNSELALTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPP 695
                     ..|.:|     :.:...|    .|||....||:|.::...:|.:            
Mouse   267 ---------RDGGTE-----NCVQGEE----KESSNDSTSVSAVASNMRDDEI------------ 301

  Fly   696 ARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFA 760
                            |..:|   :.|.||..:.:.|.                           
Mouse   302 ----------------TQDEN---TVSTSLGHSKDDNS--------------------------- 320

  Fly   761 KVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTP 825
               |::||                                             |:.|.|      
Mouse   321 ---RQTCI---------------------------------------------KIVTKT------ 331

  Fly   826 QSAAGVTPPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANRE 890
            |.....||                      ||.|....|..|..|:                  |
Mouse   332 QKGDACTP----------------------TSTTVELVGSSGQNGD------------------E 356

  Fly   891 EKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACW 955
            ::::.|.:       |..:.|....||..|              :|.:|..|||..||..|:..|
Mouse   357 KQNIVARK-------IVKMTKQPAKKKPPP--------------SREKKVTRTILAILLAFIITW 400

  Fly   956 TPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012
            .||:|:.|:..||  .|||...::...|:|||.||.:||.||||.|..|||||..:|
Mouse   401 APYNVMVLINTFC--APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 63/175 (36%)
TM helix 2 168..194 CDD:320429 13/25 (52%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 4/22 (18%)
TM helix 5 293..322 CDD:320429 6/28 (21%)
7tm_GPCRs <932..1008 CDD:475119 34/75 (45%)
TM helix 6 941..963 CDD:410628 10/21 (48%)
TM helix 7 976..1001 CDD:410628 12/24 (50%)
Chrm2NP_987076.2 7tmA_mAChR_M2 24..451 CDD:320424 157/873 (18%)
TM helix 1 25..51 CDD:320424 7/25 (28%)
TM helix 2 58..84 CDD:320424 13/25 (52%)
TM helix 3 96..126 CDD:320424 14/29 (48%)
Important for signaling 120..122 1/1 (100%)
TM helix 4 138..161 CDD:320424 4/22 (18%)
TM helix 5 183..212 CDD:320424 6/122 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..320 32/310 (10%)
TM helix 6 380..410 CDD:320424 13/29 (45%)
TM helix 7 419..444 CDD:320424 12/24 (50%)
Important for signaling 436..440 2/3 (67%)

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